Cathy Emmas

Reply to Liu et al., Zhou et al., and Dong et al.

Mohsen Sadatsafavi, Trung N. Tran, Ghislaine Scélo, David Price et autres

International audience

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Prevention of Cardiovascular and Other Systemic Adverse Outcomes in Patients with Asthma Treated with Biologics

Mohsen Sadatsafavi, Trung N. Tran, Ghislaine Scélo, Ming‐Ju Tsai et autres

Abstract Rationale Although clinical trials have documented the oral corticosteroid (OCS)-sparing effect of biologics in patients with severe asthma, little is known about whether this translates to a reduction of new-onset OCS-related adverse outcomes. Objectives To compare the risk of developing new-onset …

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OP0203 ATTAINMENT OF LLDAS AND DORIS REMISSION DURING ANIFROLUMAB TREATMENT: INTERIM 6-MONTH RESULTS FROM A MULTINATIONAL, OBSERVATIONAL, POST-LAUNCH STUDY OF TREATMENT EFFECTIVENESS IN THE REAL WORLD

M. Mosca, Z. Amoura, J. Weinmann-Menke, Mark Matsos et autres

Background: The Anifrolumab Study of Treatment Effectiveness in the Real World (ASTER; NCT05637112), is a multi-national, prospective, observational study assessing the effectiveness of anifrolumab in patients with systemic lupus erythematosus (SLE) in routine clinical practice. Post-hoc analyses of the phase 3 TULIP-1/-2 …

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Impact of Biologic Initiation on New-onset of Corticosteroid-related Adverse Effects in Patients With Severe Asthma

David Price, B. Emmanuel, G. Scelo, Alan Altraja et autres

Abstract RATIONALE: Use of oral corticosteroids (OCS), both as maintenance treatment and for exacerbations, is associated with serious adverse effects (AEs). Biologic use decreases the need for OCS in patients with severe asthma and therefore could reduce the risk of OCS-related AEs. …

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Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data

Wenjia Chen, Trung N. Tran, John Townend, George Christoff et autres

BACKGROUND: For severe asthma (SA) management, real-world evidence on the effects of biologic therapies in reducing the burden of oral corticosteroid (OCS) use is limited. OBJECTIVE: To estimate the efficacy of biologic initiation on total OCS (TOCS) exposure in patients with SA …

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Anifrolumab Study for Treatment Effectiveness in the Real World (ASTER) among patients with systemic lupus erythematosus: protocol for an international observational effectiveness study

Marta Mosca, Cathy Emmas, Cassandra Nan, Heide Stirnadel-Farrant et autres

INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a diverse clinical presentation that involves multiple organ systems and may lead to organ damage and increased risk of mortality. SLE is associated with a high burden of disease that can …

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AB0546 DESIGN OF ANIFROLUMAB STUDY OF TREATMENT EFFECTIVENESS IN THE REAL WORLD (ASTER): A MULTI-NATIONAL, OBSERVATIONAL, POST-LAUNCH STUDY TO DESCRIBE THE CLINICAL EFFECTIVENESS OF ANIFROLUMAB IN ROUTINE CLINICAL PRACTICE IN PATIENTS WITH SLE

Marta Mosca, Cathy Emmas, Cassandra Nan, Heide A. Stirnadel-Farrant et autres

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Impact of the COVID-19 Pandemic on Exacerbation Rates in Patients with Asthma and/or Chronic Obstructive Pulmonary Disease in the NOVELTY Study

Hana Muellerova, Rod Hughes, B. Fenby, C. Keen Fredriksson et autres

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Summary of the 12 Most Common Cancers in the CancerLinQ Discovery (CLQD) Database

Danielle Potter, Mark Riffon, Brittany Manning, Aliki Taylor et autres

PURPOSE: In 2014, the ASCO developed CancerLinQ (CLQ), a health technology platform for oncology. The CLQ Discovery (CLQD) database was created to make data available for research and this paper provides a summary of this database. METHODS: This study described the clinical …

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Characteristics, Symptom Severity, and Experiences of Patients Reporting Chronic Kidney Disease in the PatientsLikeMe Online Health Community: Retrospective and Qualitative Study

Glen James, Elisabeth Nyman, Marcy Fitz-Randolph, Anna Niklasson et autres

BACKGROUND: Chronic kidney disease (CKD) is a major global health burden, and is associated with increased adverse outcomes, poor quality of life, and substantial health care costs. While there is an increasing need to build patient-centered pathways for improving CKD management in …

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Characteristics, Symptom Severity, and Experiences of Patients Reporting Chronic Kidney Disease in the PatientsLikeMe Online Health Community: Retrospective and Qualitative Study (Preprint)

Glen James, Elisabeth Nyman, Marcy Fitz-Randolph, Anna Niklasson et autres

BACKGROUND Chronic kidney disease (CKD) is a major global health burden, and is associated with increased adverse outcomes, poor quality of life, and substantial health care costs. While there is an increasing need to build patient-centered pathways for improving CKD management in …

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Characteristics and Symptom Severity of Patients Reporting Systemic Lupus Erythematosus in the PatientsLikeMe Online Health Community: A Retrospective Observational Study

Elisabeth Nyman, Timothy E. Vaughan, Barnabas Desta, Xia Wang et autres

INTRODUCTION: Online health communities and research networks such as PatientsLikeMe (PLM) capture patient perspectives of diseases, including systemic lupus erythematosus (SLE). We performed a retrospective observational study of data provided by patients in the PLM SLE community to characterize demographics, clinical characteristics, …

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