Moses Kapembwa

Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)

Nicholas I. Paton, Alejandro Arenas‐Pinto, Wendy Hadley, David Stacey et autres

Background: Treatment-simplification strategies are important tools for patient-centred management. We evaluated long-term outcomes from a PI monotherapy switch strategy. Methods: Eligible participants attending 43 UK treatment centres had a viral load (VL) below 50 copies/ml for at least 24 weeks on combination …

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Letter to the editor: Are we missing pancreatic exocrine insufficiency in ‘at-risk’ groups?

Moses Kapembwa, Simon Fleming, P A Batman, George E. Griffin

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HIV enteropathy and ‘Slim disease’: Historical and current perspectives

Moses Kapembwa, P A Batman, Simon Fleming, George E. Griffin

OBJECTIVES: Chronic diarrhoea and severe wasting associated with HIV infection were first described in East African patients as slim disease (SD) in 1985. The main histological features are flattening of the villi (villous atrophy) and crypt hyperplasia (elongated crypts), i.e., HIV enteropathy …

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Placental Macrophage Depletion in Foetal Capillaries of HIV-1 Infected Women Receiving Highly Active Antiretroviral Therapy (HAART): Evidence of Protective Role in Materno-Foetal HIV Transmission?

Moses Kapembwa, Fabio Argentina, Paul Sibbons, Parjiat Bhatterchajee et autres

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Iatrogenic cushings syndrome precipitated by fluticasone nasal drops in HIV infected patient

Parizad Avari, Carmel Duffy, Moses Kapembwa, Asjid Qureshi

A 43 year old Somali woman presented with increasing fatigue, difficulty getting out of her chair and 15kg weight gain over one month.• Past medical history included paranoid psychosis, human immunodeficiency virus (HIV) and nasal congestion due to adenotonsillar hypertrophy.She declined surgery …

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O09 The impact of an HPV vaccination programme in young men who have sex with men (MSM) on clinical presentations with genital warts

Harry Coleman, Nigel O’Farrell, Moses Kapembwa, Gary Brook et autres

Introduction We introduced a quadrivalent HPV (HPV4) vaccination programme in young MSM <27yrs attending our clinical services (Clinic 1 & 2) since 2012. We assess the impact on attendance with genital warts (GW) subsequent to vaccination in this population and an adjoining …

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Outcomes of bariatric surgery in human immunodeficiency virus positive individuals: a single center experience.

Maryam Alfa‐Wali, Shivshankar Seechurn, Olubaniyi Ayodeji, Mark Nelson et autres

BACKGROUND: Obesity is a global pandemic that is also affecting HIV-positive individuals receiving combined anti-retroviral therapy. We present the outcomes of a cohort of HIV-positive individuals who underwent bariatric surgery in a single centre. The primary outcome was weight loss including secondary …

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P128 Human papillomavirus (HPV) vaccination in young men who have sex with men (MSM) in the UK. An online survey of attitudes, intentions and opinions among MSM offered vaccination within integrated sexual health services: Abstract P128 Table 1

John McSorley, Tapiwa Zhou, Patrick Kuria, Moses Kapembwa et autres

Background We have offered quadrivalent HPV vaccine (HPV4) to MSM under 27 years since 2012. We have observed a 60% 3 dose completion rate within 1 year. Aims (1) To identify motivating factors or barriers influencing HPV4 completion in a cohort of …

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PD-1 Expression and Cytokine Secretion Profiles of Mycobacterium tuberculosis-Specific CD4+ T-Cell Subsets; Potential Correlates of Containment in HIV-TB Co-Infection

Katrina M. Pollock, Damien Montamat‐Sicotte, Lisa Grass, Graham Cooke et autres

HIV co-infection is an important risk factor for tuberculosis (TB) providing a powerful model in which to dissect out defective, protective and dysfunctional Mycobacterium tuberculosis (MTB)-specific immune responses. To identify the changes induced by HIV co-infection we compared MTB-specific CD4+ responses in …

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Differences in antigen‐specific CD4+ responses to opportunistic infections in HIV infection

Katrina M. Pollock, Damien Montamat‐Sicotte, Graham Cooke, Moses Kapembwa et autres

HIV-infected individuals with severe immunodeficiency are at risk of opportunistic infection (OI). Tuberculosis (TB) may occur without substantial immune suppression suggesting an early and sustained adverse impact of HIV on Mycobacterium tuberculosis (MTB)-specific cell mediated immunity (CMI). This prospective observational cohort study …

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T-Cell Immunophenotyping Distinguishes Active From Latent Tuberculosis

Katrina M. Pollock, Hilary Whitworth, Damien Montamat‐Sicotte, Lisa Grass et autres

BACKGROUND: Changes in the phenotype and function of Mycobacterium tuberculosis (M. tuberculosis)-specific CD4+ and CD8+ T-cell subsets in response to stage of infection may allow discrimination between active tuberculosis and latent tuberculosis infection. METHODS: A prospective comparison of M. tuberculosis-specific cellular immunity …

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HIV enteropathy: HAART reduces HIV-induced stem cell hyperproliferation and crypt hypertrophy to normal in jejunal mucosa

P A Batman, Moses Kapembwa, Liliana Belmonte, Gregory Tudor et autres

OBJECTIVE: To analyse the structural and kinetic response of small intestinal crypt epithelial cells including stem cells to highly active antiretroviral therapy (HAART). DESIGN: Crypt size and proliferative activity of transit and stem cells in jejunal mucosa were quantified using morphometric techniques. …

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