Chadi Abbara

Sex Differences in Fatal Poisoning Among Drug Users in France: An Exploratory Analysis of the DRAMES Register

Agathe Langlamet, Marc Manceau, Hélène Eysseric‐Guerin, Bénédicte Lelièvre et autres

BACKGROUND: The DRAMES register (Décès en Relation avec l'Abus de Médicaments Et de Substances) is a French database of drug-related deaths reported by forensic toxicology experts. This study evaluated sex differences in the substances involved in deaths, with the aim of improving …

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Pharmacogenetics in sexualized drug use: considerations for a precision addiction medicine approach

Guillaume Drevin, Marie Briet, Chadi Abbara

Sexualized drug use, commonly referred to as chemsex, involves the intentional consumption of psychoactive substances to facilitate or prolong sexual encounters, often characterized by repeated dosing and polypharmacy.1 While public health prevention initiatives have appropriately prioritized infectious disease prevention and behavioral harm …

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Unexpected Voriconazole Overexposure in a CYP2C19 Rapid Metabolizer Due to Inflammation-Induced Phenoconversion: A Short Communication

Guillaume Drevin, Nicolas Picard, Marie Briet, Chadi Abbara

BACKGROUND: Voriconazole exhibits substantial interindividual pharmacokinetic variability, largely driven by cytochrome P450 enzymes, particularly CYP2C19 and CYP3A4. Although pharmacogenetics plays a key role in predicting voriconazole exposure, systemic inflammation may transiently suppress CYP activity, leading to inflammation-induced phenoconversion. This mechanism can cause …

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Assessment of psoas muscle as an alternative matrix for postmortem toxicological screening: qualitative agreement of xenobiotic detection with femoral and cardiac Blood

Sébastien Vivares, Chadi Abbara, Nathalie Jousset, Séverine Ferec et autres

Forensic toxicology is a cornerstone of medico-legal investigations, particularly in suspected cases of poisoning. However, interpretation may be hindered by postmortem redistribution, tissue degradation, or the absence of suitable biological matrices. Indeed, in many routine forensic situations—such as massive hemorrhage, thermal injury, …

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Accidental foodborne poisoning by atropine and scopolamine: a fatal case report

Sébastien Vivares, Nathalie Jousset, Chadi Abbara, Stéphane Malbranque et autres

Tropane alkaloids such as atropine and scopolamine are naturally occurring compounds found in various plants of the Solanaceae family, notably Datura species. Although widely used in clinical settings, their potent anticholinergic properties can lead to severe toxic effects. Fatalities involving these substances …

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Metformin-related fatalities − The importance of combining forensic toxicology and postmortem biochemistry analyses in death involving antidiabetics

Guillaume Drevin, Laurent Leuger, Laura Renard, Nathalie Jousset et autres

Metformin is the most commonly used drug in the treatment of type 2 diabetes mellitus and appears as a promising drug for several other conditions. While generally well-tolerated and relatively safe, metformin can cause serious side effects, and intoxication cases have been …

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Contributions of betahydroxybutyrate (BHB) determination and thanatological biochemistry in postmortem diagnosis of ketoacidosis-related fatalities: two case reports

Aurélien Bauduin, Chadi Abbara, Stéphane Malbranque, Laura Renard et autres

Postmortem biochemical analyses are increasingly recognized as valuable tools to complement traditional forensic investigations, particularly in cases where the cause of death remains unclear after autopsy and toxicological analyses. Among these, the quantification of β-hydroxybutyrate (BHB) in femoral blood (FB) and/or vitreous …

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Pharmaceutical consultation as a harm reduction intervention in chemsex?

Chadi Abbara, Marina Babin, Marie Briet, Guillaume Drevin

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“Goofballing”: An Emerging Threat With Clinical Challenges

Guillaume Drevin, Marie Briet, Séverine Ferec, Chadi Abbara

BACKGROUND: The coinjection of methamphetamine and opioids, known as "goofballing," is an emerging practice among people who inject drugs. This combination poses significant clinical challenges due to the opposing pharmacological effects of stimulants and depressants. The increasing prevalence of this practice, particularly …

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Integrating pharmacogenetics in sport medicine: enhancing treatment precision and preventing unintentional doping violation

Guillaume Drevin, Marie Briet, Chadi Abbara

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Need for Systematic and Comprehensive Toxicological Screening Protocols in Pediatric Poisoning Cases

Guillaume Drevin, Marie Briet, Séverine Ferec, Chadi Abbara

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Interest and limits of using pharmacogenetics in MDMA-related fatalities: A case report

Guillaume Drevin, Oliver Hãhn, Nicolas Picard, Antoine Baudriller et autres

Interpreting postmortem concentrations of 3,4-Methylenedioxymethamphetamine (MDMA) remains challenging due to the wide range of reported results and the potential idiosyncratic nature of MDMA toxicity. Consequently, forensic pathologists often rely on a body of evidence to establish conclusions regarding the cause and the …

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