Fabio Villanelli

Sex hormone changes in a 24-mo dietary and physical activity randomized intervention trial in postmenopausal females: the Diet, physical Activity and Mammography study (DAMA) study

Benedetta Bendinelli, Giovanna Danza, Melania Assedi, Fabio Villanelli et autres

BACKGROUND: The role of sex steroid hormones in the etiology of several diseases, including breast and endometrial cancer, has been widely documented. In postmenopausal females, higher concentrations of estrogens and androgens are associated with a higher risk of developing breast cancer. It …

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Circulating sex hormones and volumetric breast density: A prospective study in women from the EPIC Florence cohort

Benedetta Bendinelli, Giovanna Danza, Melania Assedi, Fabio Villanelli et autres

Abstract Mammographic breast density (MBD) is a known risk factor for breast cancer. This study aimed to evaluate prospectively how circulating levels of sex hormones and sex hormones binding globulin (SHBG) are associated with volumetric percent density (VPD, %) and absolute breast …

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The 3D in vitro Adrenoid cell model recapitulates the complexity of the adrenal gland

Serena Martinelli, Giulia Cantini, Arianna Pia Propato, Danièle Bani et autres

The crosstalk between the chromaffin and adrenocortical cells is essential for the endocrine activity of the adrenal glands. This interaction is also likely important for tumorigenesis and progression of adrenocortical cancer and pheochromocytoma. We developed a unique in vitro 3D model of …

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The regulatory effect of sex steroids on the RhoA/ROCK pathway in the rat distal vagina

Ilaria Cellai, Paolo Comeglio, Sandra Filippi, Serena Martinelli et autres

BACKGROUND: Sex steroids have been demonstrated as important modulators of vaginal function. The RhoA/ROCK calcium-sensitizing pathway plays a role in genital smooth muscle contractile mechanism, but its regulation has never been elucidated. AIM: This study investigated the sex steroid regulation of the …

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054 Insight on the Intracrinology of Menopause: Androgen Production within the Human Vagina

Paolo Comeglio, Elisa Maseroli, Ilaria Cellai, Vincenza Di Stasi et autres

ABSTRACT Introduction The human vagina is extremely sensitive to hormonal changes occurring during the woman's lifetime, in particular the decline in estrogens that characterizes the menopause is known to induce a range of genital and sexual symptoms (dryness, burning, irritation, lack of …

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Testosterone positively regulates vagina NO-induced relaxation: an experimental study in rats

Ilaria Cellai, Sandra Filippi, Paolo Comeglio, Sarah Cipriani et autres

PURPOSE: Female sexual response involves a complex interplay between neurophysiological mechanisms and the nitric oxide (NO)-mediated relaxation of clitoris and vagina. The aim of this study was to evaluate sex steroids regulation of the relaxant pathway in vagina, using a validated animal …

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Insight on the intracrinology of menopause: androgen production within the human vagina

Sarah Cipriani, Ilaria Cellai, Stasi Vincenza Di, Paolo Comeglio et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Insight on the intracrinology of menopause: androgen production within the human vagina

Sarah Cipriani, Ilaria Cellai, Stasi Vincenza Di, Paolo Comeglio et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Insight on the Intracrinology of Menopause: Androgen Production within the Human Vagina

Ilaria Cellai, Vincenza Di Stasi, Paolo Comeglio, Elisa Maseroli et autres

In this study, we investigated steroidogenic gene mRNA expression in human vaginas and verified the ability of human vagina smooth muscle cells (hvSMCs) to synthesize androgens from upstream precursor dehydroepiandrosterone (DHEA). As a readout for androgen receptor (AR) activation, we evaluated the …

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Insight on the intracrinology of menopause: androgen production within the human vagina

Sarah Cipriani, Ilaria Cellai, Stasi Vincenza Di, Paolo Comeglio et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Data in support for the measurement of heparan sulfate and dermatan sulfate by LC–MS/MS analysis

G Forni, Sabrina Malvagia, Silvia Funghini, Emanuela Scolamiero et autres

This article provides supplementary data for the paper "LC-MS/MS method for simultaneous quantification of heparan sulfate and dermatan sulfate in urine by butanolysis derivatization" (Forni et al., 2018). Several parameters were tested to optimize sample preparation by butanolysis in order to carry …

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LC-MS/MS method for simultaneous quantification of heparan sulfate and dermatan sulfate in urine by butanolysis derivatization

G Forni, Sabrina Malvagia, Silvia Funghini, Emanuela Scolamiero et autres

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