Sachio Fushida

Scheduled intravenous acetaminophen versus thoracic epidural analgesia for postoperative pain control after minimally invasive gastrectomy: multicentre randomized non-inferiority trial

Jun Kinoshita, Saki Hayashi, Toshikatsu Tsuji, Hideki Moriyama et autres

BACKGROUND: Thoracic epidural analgesia (TEA) is widely used for postoperative pain control in abdominal surgery, but its role in minimally invasive procedures remains unclear. This pragmatic multicentre open-label randomized non-inferiority trial evaluated whether scheduled intravenous acetaminophen combined with local wound infiltration provides …

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Histologic Types of Peritoneal Disease in Pseudomyxoma Peritonei as Prognostic Factor.

Yutaka Yonemura, Haruaki Ishibashi, Akiyoshi Mizumoto, Takuji Fujita et autres

The present study aims the prognostic significance of the histologic classification of peritoneal disease of pseudomyxoma peritonei(PMP)from appendix. PATIENTS: During the last 15 years, 1,117 patients were histologically diagnosed for primary and peritoneal disease components according to the new WHO classification by …

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Effect of Hyperthermic Intraperitoneal Chemotherapy on Long Term Survival in Gastric Cancer with Peritoneal Metastasis Treated With Preoperative Intraperttoneal Chemotherapy plus Peritonectomy: The Phase III PM-GC-1 Trial

Yutaka Yonemura, Haruaki Ishibashi, Takuji Fujita, Yang Liu et autres

The presentation aims to describe the theory for Comprehensive Treatment (COMPT) in order to achieve cure of Colorectal Cancer (CRC)-patients with Peritoneal Metastasis (PM). Comprehensive Treatment (COMPT) consists of complete resection of macroscopic PM and eradication of residual MicroM metastasis (MM) by …

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Effects of Hyperthermic Intraperitoneal Chemotherapy and Intraperitoneal Chemotherapy for Well-Differentiated Papillary Mesothelioma

Yutaka Yonemura, Haruaki Ishibashi, Ching-Hsien Ling, Takuji Fujita et autres

Abstract Objective: Well-Differentiated Papillary Mesothelioma (WDPM) is a rare disease, with no consensus recommendation for treatment. In the present article, we propose novel treatment options for the treatment of WDPM. Methods: From 2006 to 2023, nine patients (five male, four femail) were …

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Phase II Study of Intraperitoneal Administration of Paclitaxel Combined with S-1 and Cisplatin for Gastric Cancer with Peritoneal Metastasis

Daisuke Kobayashi, Yasuhiro Kodera, Ryoji Fukushima, Masaru Morita et autres

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ASO Visual Abstract: Phase II Study of Intraperitoneal Administration of Paclitaxel Combined with S-1 and Cisplatin for Gastric Cancer with Peritoneal Metastasis

Daisuke Kobayashi, Yasuhiro Kodera, Ryoji Fukushima, Masaru Morita et autres

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ASO Visual Abstract: Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake

Tatsuya Aoki, Jun Kinoshita, Seiichi Munesue, Toshihide Hamabe‐Horiike et autres

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Successful second conversion surgery after trastuzumab deruxtecan for recurrent HER2-positive gastric cancer

Takeshi Terashima, Tatsuya Yamashita, Hisashi Takabatake, Shinichi Nakanuma et autres

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Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake

Tatsuya Aoki, Jun Kinoshita, Seiichi Munesue, Toshihide Hamabe‐Horiike et autres

BACKGROUND: The lipid scavenger receptor cluster of differentiation 36 (CD36) has been shown to have a pro-metastatic function in several cancers. Adipose tissue, a favorable site for peritoneal metastasis (PM) from gastric cancer (GC), promotes this process by providing free fatty acids …

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O1-6 REVIVE study: An observational study in chemotherapy (CTx) after nivolumab (NIVO) for advanced gastric cancer (AGC)

Yasuhiro Sakamoto, Yukiya Narita, Toshihiro Misumi, Hiroshi Matsuoka et autres

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Adipocytes contribute to tumor progression and invasion of peritoneal metastasis by interacting with gastric cancer cells as cancer associated fibroblasts

Toshihide Hamabe‐Horiike, Shinichi Harada, Kyoko Yoshida, Jun Kinoshita et autres

BACKGROUND: Peritoneal metastasis (PM) is one of the most common causes of noncurative surgery and the most frequent recurrence pattern in gastric cancer (GC). During the process of PM, GC cells detached from primary tumor interact with human peritoneal mesothelial cells (HPMC) …

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Prognostic value of tumor-infiltrating CD163+macrophage in patients with metastatic gastric cancer undergoing multidisciplinary treatment

Jun Kinoshita, Sachio Fushida, Takahisa Yamaguchi, Hideki Moriyama et autres

Abstract Background The multidisciplinary treatment including induction chemotherapy plus conversion surgery (CS) has attracted attention as a new strategy to improve the outcome of metastatic gastric cancer (MGC). However, it is unclear which patients achieve a good response to chemotherapy and successful …

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