Giancarlo Bosio

Mapping the human genetic architecture of COVID-19

Mari Niemi, Juha S. Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …

fi, us, es, de, it, gb, nl, ca, kr, jp, ae, fr, au, pl, in, be, qa, dk, cl, pr, mx (code pays fourni par la source)

COVID-19: high-resolution computed tomography findings in the first 64 patients admitted to the Hospital of Cremona, the epicentre of the pandemic in Europe

Vittorio Sabatino, Pietro Sergio, Margherita Muri, Ilaria Zangrandi et autres

Introduction In December 2019, a new coronavirus (SARS-CoV-2) was identified as being responsible for the pulmonary infection called COVID-19. On 21 February 2020, the first autochthonous case of COVID-19 was detected in Italy. Our goal is to report the most common chest …

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Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

Chiara Fallerini, Sergio Daga, Stefania Mantovani, Elisa Benetti et autres

Background: Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families represent the tip of the iceberg of a subset of COVID-19 male …

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Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

Margherita Baldassarri, Nicola Picchiotti, Francesca Fava, Chiara Fallerini et autres

BACKGROUND: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. METHODS: We compared poly-amino acids variability from WES data in severely affected COVID-19 patients …

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Author response: Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

Chiara Fallerini, Sergio Daga, Stefania Mantovani, Elisa Benetti et autres

Background: Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2.We investigated whether the two families represent the tip of the iceberg of a subset of COVID-19 male patients.Methods: …

it, us, pl, fr (code pays fourni par la source)

Noninvasive Ventilatory Support of Patients with COVID-19 outside the Intensive Care Units (WARd-COVID)

Giacomo Bellani, Giacomo Grasselli, Maurizio Cecconi, Laura Antolini et autres

Abstract Rationale Treatment with noninvasive ventilation (NIV) in coronavirus disease (COVID-19) is frequent. Shortage of intensive care unit (ICU) beds led clinicians to deliver NIV also outside ICUs. Data about the use of NIV in COVID-19 is limited. Objectives To describe the …

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Canakinumab as treatment for COVID-19-related pneumonia: A prospective case-control study

Daniele Generali, Giancarlo Bosio, Fabio Malberti, Cuzzoli Antonio et autres

Objectives Canakinumab is an IL-1β antibody that neutralises the activity of IL-1β. This study examined the efficacy and safety of canakinumab in patients with moderate COVID-19-related pneumonia. Design This study aimed to evaluate the reduction in duration of hospitalisation with adequate oxygen …

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Prevalence of asymptomatic deep vein thrombosis in patients hospitalized with SARS-CoV-2 pneumonia: a cross-sectional study

Matteo Giorgi‐Pierfranceschi, Oriana Paoletti, Angelo Pan, Fabio De Gennaro et autres

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Suggestions from Cremona, Italy: 2 months into the pandemic at the frontline of COVID-19 in Europe

Angelo Pan, Matteo Giorgi‐Pierfranceschi, Giancarlo Bosio, L. Cammelli et autres

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Congenital absence of pericardium: two cases and a comprehensive review of the literature

Pietro Sergio, Erika Bertella, Margherita Muri, Ilaria Zangrandi et autres

Congenital absence of pericardium (CAP) is a rare condition, generally asymptomatic or paucisymptomatic, nevertheless sporadic cases complicated by sudden death are described. CAP can be diagnosed by CT and MRI. It is classified as total or partial, and partial defects are divided …

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Estimation of economic consequences of GOLD guidelines adoption in the Italian clinical practice

Orietta Zaniolo, Germano Bettoncelli, Giancarlo Bosio, LG Mantovani et autres

Background: Chronic Obstructive Pulmonary Disease (COPD) affects about 4.5% of the Italian population, representing one of most burdensome public health problems. Literature data report an annual health care expenditure ranging between € 1,300 and € 4,500 per patient, of which drug costs …

PRS72 How Much Would the Universal Uptake of Gold Recommendations for Italian COPD Patients Cost?

Orietta Zaniolo, Germano Bettoncelli, Giancarlo Bosio, LG Mantovani et autres

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