Arthur Williams

Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment

Rachel F. Buckley, Diana L Townsend, Colin Birkenbihl, Madison Cuppels et autres

Importance: Blood-based biomarkers for Alzheimer disease, particularly plasma phosphorylated tau 217 (p-tau217), accurately reflect early Alzheimer disease brain pathology in cognitively unimpaired individuals, but estimates of absolute risk of progression to cognitive impairment across multiple cohorts are needed. Objective: To estimate absolute …

au, us, de, nl (code pays fourni par la source)

Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegeneration

Nikhil N. Chaudhari, Owen M. Vega, Phoebe E. Imms, Jaron Kawamura et autres

Abstract Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks …

us, gb (code pays fourni par la source)

Alzheimer Disease–Relevant Biomarker Elevations in Psychosis and Broad Neuropsychiatric Impairment

Michael J. C. Bray, Jacob S. Shaw, Christopher B. Morrow, Chiadi U. Onyike et autres

This cohort study examines the association of serum hyperphosphorylated tau and neurofilament light chain concentrations with psychosis in Alzheimer disease.

us (code pays fourni par la source)

A Machine Learning Approach to Predict Cognitive Decline in Alzheimer Disease Clinical Trials

Bhargav Teja Nallapu, Kellen K. Petersen, Tianchen Qian, İdris Demirsoy et autres

BACKGROUND AND OBJECTIVES: Among the participants of Alzheimer disease (AD) treatment trials, 40% do not show cognitive decline over 80 weeks of follow-up. Identifying and excluding these individuals can increase power to detect treatment effects. We aimed to develop machine learning-based predictive …

us, tr (code pays fourni par la source)

Deep learning to quantify the pace of brain aging in relation to neurocognitive changes

Chenzhong Yin, Phoebe E. Imms, Nahian F. Chowdhury, Nikhil N. Chaudhari et autres

Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since birth. Thus, it conveys poorly recent or contemporaneous …

us (code pays fourni par la source)

Learning-based inference of longitudinal image changes: Applications in embryo development, wound healing, and aging brain

Heejong Kim, Batuhan K. Karaman, Qingyu Zhao, Alan Q. Wang et autres

Longitudinal imaging data are routinely acquired for health studies and patient monitoring. A central goal in longitudinal studies is tracking relevant change over time. Traditional methods remove nuisance variation with custom pipelines to focus on significant changes. In this work, we present …

us, ca, jp (code pays fourni par la source)

Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment

Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca et autres

White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating brain health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH …

de, nl, us, at, ch, sg, ca (code pays fourni par la source)

Towards cascading genetic risk in Alzheimer’s disease

André Altmann, Leon Aksman, Neil P. Oxtoby, Alexandra L. Young et autres

Alzheimer's disease typically progresses in stages, which have been defined by the presence of disease-specific biomarkers: amyloid (A), tau (T) and neurodegeneration (N). This progression of biomarkers has been condensed into the ATN framework, in which each of the biomarkers can be …

gb, us (code pays fourni par la source)

Calculating Drug Doses Safely: A Handbook for Nurses and Midwives

George Downie, Jean Mackenzie, Arthur Williams

Calculating drug doses safely: a handbook for nurses and midwives , Calculating drug doses safely: a handbook for nurses and midwives , کتابخانه مرکزی دانشگاه علوم پزشکی تهران

The nurse consultant role as identified by directors of nursing in selected Montana nursing homes

Arthur Williams

Labor's Share in Ownership

Arthur Williams

Arthur Williams, Labor's Share in Ownership, Proceedings of the Academy of Political Science in the City of New York, Vol. 11, No. 3, Popular Ownership of Property: Its Newer Forms and Social Consequences (Apr., 1925), pp. 6-14

Industry and the Health of the Employe

Arthur Williams