Nathan T. James

16 Establishing the impact of dedicated MDT and alert system for the management of pulmonary nodules in a tertiary referral centre

Nathan T. James, Mikolasch Theresia A, Verissimo Tiago, Kotnik Marusa et autres

gb (code pays fourni par la source)

Widespread non-adherence to guidelines in the operative management of diabetes-related foot disease complications

Bryce Renwick, Maria Gannon, S Kerr, R Melvin et autres

The incidence of diabetes is increasing1–3. One of the most common complications is diabetes-related foot disease (DFD), which include ulcers and gangrene. If not managed appropriately, DFD can rapidly deteriorate resulting in limb loss and death4–6. The International Working Group on the …

gb (code pays fourni par la source)

A randomized, embedded, pragmatic, Bayesian clinical trial examining clinical decision support for high flow nasal cannula management in children with bronchiolitis: design and statistical analysis plan

Christopher M. Horvat, Srinivasan Suresh, Nathan T. James, Rajesh K. Aneja et autres

BACKGROUND: High flow nasal cannula (HFNC) has been increasingly adopted in the past 2 decades as a mode of respiratory support for children hospitalized with bronchiolitis. The growing use of HFNC despite a paucity of high-quality data regarding the therapy's efficacy has …

us (code pays fourni par la source)

Addressing Multiple Detection Limits with Semiparametric Cumulative Probability Models

Yuqi Tian, Chun Li, Shengxin Tu, Nathan T. James et autres

Detection limits (DLs), where a variable cannot be measured outside of a certain range, are common in research. DLs may vary across study sites or over time. Most approaches to handling DLs in response variables implicitly make strong parametric assumptions on the …

us (code pays fourni par la source)

multipleDL: Addressing Detection Limits by Cumulative Probability Models (CPMs)

Yuqi Tian, Chun Li, Shengxin Tu, Nathan T. James et autres

Build CPMs (cumulative probability models, also known as cumulative link models) to account for detection limits (both single and multiple detection limits) in response variables. Conditional quantiles and conditional CDFs can be calculated based on fitted models. The package implements methods described …

Variant‐based heritability assessment of dexmedetomidine and fentanyl clearance in pediatric patients

Morgan L. Shannon, Ayesha Muhammad, Nathan T. James, Michael L. Williams et autres

Abstract Despite complex pathways of drug disposition, clinical pharmacogenetic predictors currently rely on only a few high effect variants. Quantification of the polygenic contribution to variability in drug disposition is necessary to prioritize target drugs for pharmacogenomic approaches and guide analytic methods. …

us (code pays fourni par la source)

Addressing Detection Limits with Semiparametric Cumulative Probability Models

Yuqi Tian, Chun Li, Shengxin Tu, Nathan T. James et autres

Detection limits (DLs), where a variable is unable to be measured outside of a certain range, are common in research. Most approaches to handle DLs in the response variable implicitly make parametric assumptions on the distribution of data outside DLs. We propose …

Population pharmacokinetic analysis of dexmedetomidine in children using real‐world data from electronic health records and remnant specimens

Nathan T. James, Joseph H. Breeyear, Richard M. Caprioli, Todd L. Edwards et autres

AIMS: Our objectives were to perform a population pharmacokinetic analysis of dexmedetomidine in children using remnant specimens and electronic health records (EHRs) and explore the impact of patient's characteristics and pharmacogenetics on dexmedetomidine clearance. METHODS: Dexmedetomidine dosing and patient data were gathered …

us (code pays fourni par la source)

Electronic Health Record (EHR) Data Processing and Analysis Tool [R package EHR version 0.4-4]

Leena Choi, Cole Beck, Hannah L. Weeks, Elizabeth A. McNeer et autres

Electronic Health Record (EHR) Data Processing and Analysis Tool [R package EHR version 0.4-1]

Leena Choi, Cole Beck, Hannah L. Weeks, Elizabeth A. McNeer et autres

Population Pharmacokinetic Analysis of Dexmedetomidine in Children using Real World Data from Electronic Health Records and Remnant Specimens

Nathan T. James, Joseph H. Breeyear, Richard M. Caprioli, Todd L. Edwards et autres

Abstract Aim Our objectives were to perform a population pharmacokinetic analysis of dexmedetomidine in children using remnant specimens and data from electronic health records (EHRs) and explore the impact of patient’s characteristics and pharmacogenetics on dexmedetomidine clearance. Methods Dexmedetomidine dosing and patient …

us (code pays fourni par la source)

Bayesian Cumulative Probability Models for Continuous and Mixed Outcomes

Nathan T. James, Frank E. Harrell, Bryan E. Shepherd

Ordinal cumulative probability models (CPMs) -- also known as cumulative link models -- such as the proportional odds regression model are typically used for discrete ordered outcomes, but can accommodate both continuous and mixed discrete/continuous outcomes since these are also ordered. Recent …