Claudia Ciniglia

Additive effect of Ruta graveolens bioactive phytoconstituents and cisplatin through PKC/MEK/ERK pathway in glioblastoma

Grazia Romano, Valentina Morgera, Antonio Pezone, Samantha Messina et autres

-diamminedichloroplatinum (cisplatin, CDDP). Cytostatic responses were assessed by cell viability (TB exclusion test), cell cycle (propidium iodide [PI] staining), and apoptosis (Annex-V and caspase-3) assays. We demonstrate that RGWE slows U-87 MG growth without affecting apoptosis and arrests the cell cycle in …

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Marine epiphytic diatoms: a review of environmental controls and ecosystem roles

Concetta Auciello, Claudia Ciniglia, Manuela Iovinella, Elio Pozzuoli et autres

Epiphytic diatom assemblages constitute a crucial component of coastal microbenthic ecosystems, yet they remain underexplored compared to other microbenthic organisms. This review provides a comprehensive synthesis of current knowledge on the ecological patterns, drivers, and functional significance of epiphytic diatoms colonizing marine …

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From Metal-Related Public Health Risks to Bioremediation: The Potential of the Polyextremophilic Galdieria spp.—A Systematic Review

Elio Pozzuoli, Concetta Auciello, Salvatore Avilia, Manuela Iovinella et autres

The growing demand for rare earth elements (REEs), heavy metals (HMs) and precious metals (PMs) has intensified interest in sustainable recovery strategies from secondary resources, including mining residues, industrial effluents and waste electrical and electronic equipment (WEEE). These streams represent exposure interfaces, …

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Sequential valorisation of Galdieria daedala biomass for C-phycocyanin extraction and rare earth elements recovery from waste of electric and electronic equipment leachates

Elio Pozzuoli, Concetta Auciello, Manuela Iovinella, Maria Rosa di Cicco et autres

Rare Earth Elements (REEs) recovery from Waste Electrical and Electronic Equipment (WEEE) requires sustainable alternatives to conventional, energy-intensive extraction processes. This study proposes an integrated biorefinery strategy based on the extremophilic red microalga Galdieria daedala for sequential C-phycocyanin (C-PC) extraction and subsequent …

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Nuclear and organellar phylogenies provide insights into evolutionary history and species boundaries in Galdieria

Manuela Iovinella, Sarah C. L. Lock, Luke C M Mackinder, James P.J. Chong et autres

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Biological and economic advantages of C-Phycocyanin production from red algae (Rhodophyta), yield optimization and sustainability strategies: a systematic review

Elio Pozzuoli, Concetta Auciello, Salvatore Avilia, Lugi Marra et autres

Microalgae are gaining interest as sustainable biofactories for the industrial-scale production of Phycocyanin (PC), a phycobiliprotein (PBP) with significant antioxidant, anti-inflammatory, and nutraceutical properties. Among them, red extremophilic species such as Galdieria spp. have emerged as particularly promising sources due to their …

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Impact of pH on the efficacy of Galdieria sulphuraria ACUF 427 in urban wastewater treatment: Effects on contaminant removal, biomass, and phycocyanin production

Manuela Iovinella, Elio Pozzuoli, Salvatore Avilia, Giovanna Scione et autres

Abstract Environmental pollution, driven by increasing human population and urbanization, generates significant waste. Utilizing microalgae to treat urban wastewater is a promising solution to current water pollution challenges. This research investigates the treatment of primary-settled urban wastewater at initial pH levels of …

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Optimising Galdieria sulphuraria ACUF 427 Biomass for Enhanced Urban Wastewater Treatment: Evaluating Pollutant Removal Efficiency, Algal Growth, and Phycocyanin Production

Manuela Iovinella, Claudia Ciniglia

Urban wastewater is composed of nutrients such as nitrogen and phosphorus, organic matter, heavy metals, pathogens, and micropollutants. If untreated, these contribute to eutrophication and environmental degradation. Microalgae-based bioremediation offers a sustainable solution, showing promise for pollutant removal and high-value bioproduct generation. …

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Mosaic Evolution of Membrane Transporters in Galdieriales

Claudia Ciniglia, Antonino Pollio, Elio Pozzuoli, Marzia Licata et autres

Membrane transporters are vital for solute movement and localisation across cellular compartments, particularly in extremophilic organisms such as Galdieriales. These red algae thrive in geothermal and metal-rich environments, where adaptive transporter systems contribute to their metabolic flexibility. While inventories of transporter genes …

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A Review on Innovative Strategies Towards Sustainable Drug Waste Management Through Algae-Based Systems

Salvatore Avilia, Elio Pozzuoli, Manuela Iovinella, Claudia Ciniglia et autres

Drug removal from urban wastewater (UW) is a topic of growing interest. The new European Directive addresses this problem by introducing quaternary treatment by 2045, as part of the “Zero Pollution” plan from a One Health perspective. In this context, the role …

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Rare earth elements recovery from bauxite by biosorption onto Galdieria sulphuraria: A challenging case of study

Carla Manfredi, Claudia Ciniglia, Antonella Giarra, Manuela Iovinella et autres

ABSTRACT This paper describes a preliminary study on the recovery of rare earth elements (REEs) from bauxite aqueous suspensions by biosorption onto Galdieria sulphuraria a red microalga belonging to Cyanidiophyte ( Rhodophyta ) class. REEs are strategic commodities in many countries, and …

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Sustainable Cultivation of Galdieria phlegrea in an IoT-Integrated Twin-Layer Photobioreactor: System Design, Growth Dynamics, and Isotopic Perspective

Maria Rosa di Cicco, Simona Altieri, Antonio Spagnuolo, Claudia Ciniglia et autres

This study showcases an attached-biomass system based on twin-layer technology for cultivating Galdieria phlegrea using municipal wastewater, equipped with a smart sensor system for the remote monitoring of operational parameters. From an industrial scale-up perspective, the system offers high scalability, with low …

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