Gerhard Zugmaier

Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia

Martin Schrappe, Franco Locatelli, Maria Grazia Valsecchi, Gerhard Zugmaier et autres

BACKGROUND: Blinatumomab, a bispecific T-cell engager targeting the CD19 antigen on B cells, may offer an option to safely replace cycles of traditional chemotherapy in pediatric patients with newly diagnosed high-risk B-cell acute lymphoblastic leukemia (ALL). METHODS: We randomly assigned, in a …

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Boolean Algebra in Diagnostics, Risk Stratification, and Treatment Decisions in Acute Lymphoblastic Leukemia

Gerhard Zugmaier

Background: Acute lymphoblastic leukemia (ALL) is a biologically heterogeneous malignancy of precursor lymphoid cells whose diagnosis and management require integrated interpretation of morphology, flow cytometry, cytogenetics, molecular genetic alterations, clinical context, and treatment response. Contemporary classification and management frameworks emphasize that ALL …

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Real-world effectiveness and safety of blinatumomab in adults with B-cell precursor acute lymphoblastic leukaemia across 13 European countries

Sabina Chiaretti, Sabine Blum, Thibaut Leguay, Marie Balsat et autres

Blinatumomab, a CD19/CD3-bispecific T-cell engager (BiTE ® ), is an established immunotherapy for treating measurable residual disease–positive (MRD+) and relapsed/refractory (R/R) Philadelphia chromosome–negative (Ph−) CD19–positive B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) [ 1 ]. Following conditional marketing authorisation from the European Medicines …

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Blinatumomab in Combined Immune Thrombocytopenia and Antiphospholipid Syndrome

Adrian Gottschlich, Veit Bücklein, Karim El-Marouk, Rainer Kaiser et autres

A CD19-targeted therapy induced remission in a woman with refractory immune thrombocytopenia and antiphospholipid syndrome by stabilizing platelet counts, eliminating pathogenic antibodies, and enabling safer long-term anticoagulation.

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Boolean Algebra (Mathematical Logic) for Differential Diagnosis of Psychiatric Disorders

Gerhard Zugmaier

The endemic zoonotic disease fascioliasis is very common in eastern Uttar Pradesh. The essential oils play an important role in controlling snail population. Current research shows that essential oils from various Mentha piperata and Mentha spicata plant materials are effective as phytomolluscicides …

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Blinatumomab consolidation in children with high-risk first-relapse B-cell precursor acute lymphoblastic leukemia: final 5-year follow-up analysis of a randomized multicenter phase 3 study

Franco Locatelli, Carmelo Rizzari, Bernd Gruhn, Thomas Klingebiel et autres

Qualified researchers may request data from Amgen clinical studies. Complete details are available at: http://www.amgen.com/datasharing .

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Blinatumomab mitigates the impact of traditional adverse prognosticators among children with standard risk b-acute lymphoblastic leukemia: Updated results of the Children's oncology group (COG) Trial AALL1731

Sumit Gupta, Rachel E. Rau, John A. Kairalla, Karen R. Rabin et autres

Abstract COG study AALL1731 established that adding two cycles of the bispecific T-cell engager blinatumomab to risk-adapted chemotherapy (chemo) significantly improved 3-year disease-free survival (DFS) of children with National Cancer Institute (NCI) standard risk (SR) B-acute lymphoblastic leukemia (ALL) at average or …

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Boolean Algebra (Mathematical Logic) for Differential Diagnosis of Neurologic Disorders

Gerhard Zugmaier

Background: Using Boolean algebra for differential diagnosis of neurological disorders involves treating neurologic findings and disease entities such as Boolean variables and combining them via OR (∨) or other logical operations. Aim: To demonstrate how Boolean algebra (mathematical logic) and Boolean matrices …

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Boolean Algebra (Mathematical Logic) for Diagnosis of Hematologic Disorders

Gerhard Zugmaier

Background: Using Boolean algebra to assist in the diagnosis of hematologic disorders involves applying logical operations (AND, OR, NOT, etc.) to symptoms, lab values, and clinical findings to arrive at probable diagnoses. Aim: This study used Boolean algebra (mathematical logic) to calculate …

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Subcutaneous blinatumomab in adults with relapsed or refractory B-cell acute lymphoblastic leukaemia: post-hoc safety and activity analysis from a multicentre, single-arm, phase 1/2 trial

Elias Jabbour, Federico Lussana, Pilar Martínez‐Sánchez, Anna Torrent et autres

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Pooled biomarker analysis of the association of baseline T regulatory cells with response and T-cell recovery profiles with blinatumomab treatment

Yuliya V. Katlinskaya, Bharat Panwar, Yi Zeng, Paul Gordon et autres

INTRODUCTION: Blinatumomab, a bispecific T-cell engager, requires the activity of CD3+ T-cells for tumor lysis. This pooled analysis aimed to re-examine baseline T regulatory cells (Tregs) as a biomarker of blinatumomab efficacy across multiple clinical trials and provide insights into peripheral T-cell …

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POS1113 TREATMENT OF SEVERE SYSTEMIC SCLEROSIS WITH BLINATUMOMAB, A BISPECIFIC ANTI-CD3/CD19 T CELL ENGAGER

Christoffer Gebhardt, Franziska Szelinski, H. Rincon-Arevalo, Giulia Magno et autres

Background: Systemic sclerosis (SSc) is a severe autoimmune disease in which B cells are involved in both the dysregulation of the immune system that triggers the disease and the persistent tissue fibrosis. However, B cell-depleting therapies have led to inconsistent clinical results, …

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