Giuliano Freddi

Digital nerve reconstruction with a new composite silk fibroin nerve conduit

Olga Politikou, Florian Samuel Frueh, Martina Greminger, Inga Swantje Besmens et autres

BACKGROUND AND AIMS: Peripheral nerve injuries often require bridging when direct repair is not feasible. Nerve autografts are the gold standard, but they can lead to donor site morbidity. Silk fibroin-based nerve conduits, like the novel SILKBridge, offer a promising alternative. This …

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Assessment of the advantages and limitations of an innovative silk fibroin scaffold for the reconstruction of the anterior cruciate ligament with preclinical in vitro and in vivo evaluations

Gianluca Giavaresi, Maria Sartori, Massimiliano Baleani, Silvia Brogini et autres

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List of contributors

Catarina M. Abreu, Prachi Agarwal, Olatunji Ajiteru, Antonio Alessandrino et autres

pt, in, kr, it, ir, au, th, cn, gb, hk, es (code pays fourni par la source)

Translation of a silk-based medical device from bench to bedside

Giuliano Freddi, Valeria Pisani, Gabriella Francavilla, Antonio Alessandrino

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Human Keratinocytes and Fibroblasts Co-Cultured on Silk Fibroin Scaffolds Exosomally Overrelease Angiogenic and Growth Factors

Peng Hu, Ubaldo Armato, Giuliano Freddi, Anna Chiarini et autres

Objectives: The optimal healing of skin wounds, deep burns, and chronic ulcers is an important clinical problem. Attempts to solve it have been driving the search for skin equivalents based on synthetic or natural polymers. Methods: Consistent with this endeavor, we used …

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In-vivo evaluation of silk fibroin small-diameter vascular grafts: state of art of preclinical studies and animal models

Alberto M. Settembrini, Gianluca Buongiovanni, Antonio Alessandrino, Giuliano Freddi et autres

Autologous vein and artery remains the first choice for vascular grafting procedures in small-diameter vessels such as coronary and lower limb districts. Unfortunately, these vessels are often found to be unsuitable in atherosclerotic patients due to the presence of calcifications or to …

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Antibiotic-Loaded Hyperbranched Polyester Embedded into Peptide-Enriched Silk Fibroin for the Treatment of Orthopedic or Dental Infections

Zili Sideratou, Marco Biagiotti, Dimitris Tsiourvas, Katerina N. Panagiotaki et autres

The development of innovative osteoconductive matrices, which are enriched with antibiotic delivery nanosystems, has the invaluable potential to achieve both local contaminant eradication and the osseointegration of implanted devices. With the aim of producing safe, bioactive materials that have osteoconductive and antibacterial …

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Silk Vascular Grafts with Optimized Mechanical Properties for the Repair and Regeneration of Small Caliber Blood Vessels

Elisa Valsecchi, Marco Biagiotti, Antonio Alessandrino, Dario Gastaldi et autres

As the incidence of cardiovascular diseases has been growing in recent years, the need for small-diameter vascular grafts is increasing. Considering the limited success of synthetic grafts, vascular tissue engineering/repair/regeneration aim to find novel solutions. Silk fibroin (SF) has been widely investigated …

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A Route to Translate a Silk-Based Medical Device from Lab to Clinic: The Silk Biomaterials Srl Experience

Giulia Alessandra Bassani, Valentina Vincoli, Marco Biagiotti, Elisa Valsecchi et autres

silk fibroin. It is a tubular scaffold used for repairing peripheral nerve gaps, whose function is to protect the severed nerves and to favor their natural healing process. As any implantable medical device, the conduit must perform its function without causing adverse …

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Electrospun Silk Fibroin Scaffolds for Tissue Regeneration: Chemical, Structural, and Toxicological Implications of the Formic Acid-Silk Fibroin Interaction

Marco Biagiotti, Giulia Alessandra Bassani, Anna Chiarini, Valentina Vincoli et autres

The dissolution of Bombyx mori silk fibroin (SF) films in formic acid (FA) for the preparation of electrospinning dopes is widely exploited to produce electrospun SF scaffolds. The SILKBridge® nerve conduit is an example of medical device having in its wall structure …

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Editorial: Biomaterials for Skin Wound Repair: Tissue Engineering, Guided Regeneration, and Wound Scarring Prevention

Ubaldo Armato, Giuliano Freddi

Although laypersons may not realize it, the skin or integument is the largest and heaviest organ of our body.It is of the utmost importance that as a boundary organ it keeps its integrity and functions.True, the skin's esthetic role crucially mediates social …

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Exosomes of adult human fibroblasts cultured on 3D silk fibroin nonwovens intensely stimulate neoangiogenesis

Peng Cheng Hu, Anna Chiarini, Jun Wu, Giuliano Freddi et autres

Abstract Background Bombyx mori silk fibroin is a biomacromolecule that allows the assembly of scaffolds for tissue engineering and regeneration purposes due to its cellular adhesiveness, high biocompatibility and low immunogenicity. Earlier work showed that two types of 3D silk fibroin nonwovens …

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