Accès ouvert
2026
article
OpenAlex
Margaret Stedman, C. Christina Mehta, Emily Slade, Patricia L. Hibberd et autres
Recent emphasis on transdisciplinary teams in science offers an opportunity for biostatisticians to assume roles beyond data management and analysis. Biostatisticians contribute to all phases of research, from hypothesis formulation and rigorous study design to data analysis and interpretation. Yet, their contributions …
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2026
article
OpenAlex
Chin-An Yang, Young-Mi Go, Dean P. Jones, Brahmchetna Bedi et autres
BACKGROUND: Integrase strand-transfer inhibitors (INSTIs) are associated with weight gain in people with HIV (PWH), particularly in women with HIV (WWH), but underlying mechanisms remain unclear. We used longitudinal untargeted metabolomics to identify metabolic signatures of INSTI-related weight gain in WWH. METHODS: …
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2026
article
OpenAlex
Dara Brena, Viviane Schuch, Ming‐Bo Huang, Anandi Sheth et autres
BACKGROUND: Despite virologic suppression with ART, pregnant people living with HIV (PLWH) experience a disparate risk of chronic non-AIDS-related morbidities (NAMs) during pregnancy compared to people without HIV infection including preterm labor and small for gestational age. Many studies postulate that NAMs …
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Accès ouvert
2025
article
OpenAlex
M. R. Young, C. Christina Mehta, Tyree Staple, Gina Bailey Herring et autres
Introduction Depot medroxyprogesterone acetate (DMPA) injectable, etonogestrel subdermal implant (ENG-implant), and levonorgestrel intrauterine device (LNG-IUD) are effective, widely used female hormonal contraceptives (HC). Observational studies, but not a randomized trial, suggest increased risk of HIV acquisition with HC use, particularly DMPA. Sexual …
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Accès ouvert
2025
article
OpenAlex
Jessica A. Alvarez, Sami Teeny, Chin-An Yang, C. Christina Mehta et autres
OBJECTIVE: This pilot study used metabolomics to provide insights into metabolic alterations of integrase strand transfer inhibitor (INSTI)-associated weight gain among women with HIV. METHODS: The study included 33 virally suppressed women with HIV who switched to or added an INSTI. Plasma …
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Accès ouvert
2025
article
OpenAlex
Shamie Das, Azeemuddin Ahmed, Olga Capurro, Michael Carr et autres
BACKGROUND: Sepsis is a common, life-threatening medical emergency in which early recognition and treatment are cornerstones of management. Best practice guidelines recommend standardized sepsis screening in hospitals to facilitate early recognition. In contrast, very little is known about the efficacy and safety …
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2025
article
OpenAlex
Rebecca Abelman, Yifei Ma, C. Christina Mehta, Qian Yang et autres
BACKGROUND: Switching to an integrase strand transfer inhibitor (INSTI) during the menopausal transition has been associated with accelerated increases in visceral obesity, a risk factor for insulin resistance. Whether switching to an INSTI modifies the association of HIV and menopause with insulin …
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Accès ouvert
2025
article
OpenAlex
Leora I. Horwitz, Jacqueline Becker, Weixing Huang, Teresa Akintonwa et autres
Importance: Olfactory dysfunction is common after SARS-CoV-2 infection and has been associated with cognitive loss in other conditions. Formal testing is needed to characterize the presence, severity, and patterns of olfactory dysfunction. Objective: To characterize long-term olfactory dysfunction after SARS-CoV-2 infection. Design, …
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Accès ouvert
2025
article
OpenAlex
Nishant Vatsa, Raymundo A. Quintana, Phillipp Knebel Doeberitz, Carlotta Onnis et autres
Background: Coronary high-risk plaque (HRP) is associated with inflammation and adverse outcomes in symptomatic individuals with coronary artery disease (CAD), yet determinants of HRP in asymptomatic individuals without known CAD remain ambiguous. Objectives: We examined the association between interleukin 6 (IL-6) levels …
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2025
article
OpenAlex
Michael H. Woodworth, Ahmed Babiker, Radhika Prakash-Asrani, C. Christina Mehta et autres
Importance: Intestinal multidrug-resistant organism (MDRO) colonization is highly prevalent in long-term acute care hospital (LTACH) patients and is associated with MDRO infection and transmission. However, there are no therapies approved by the US Food and Drug Administration to reduce intestinal MDRO colonization. …
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Accès ouvert
2025
article
OpenAlex
Shreya Ganguly, Olivia Christman, Qian Yang, C. Christina Mehta et autres
BACKGROUND: Housing instability is a modifiable determinant of health outcomes among people with HIV. Reproductive-age women face unique challenges and are underrepresented in HIV research. We characterized housing status among reproductive-age women with and without HIV (WWH/WWoH) and evaluated its associations with …
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Accès ouvert
2025
article
OpenAlex
Amanda R. Arnold, Heqiong Wang, C. Christina Mehta, Paula-Dene C. Nesbeth et autres
BACKGROUND: Childhood maltreatment and HIV are both associated with a greater risk for adverse mental health, including posttraumatic stress disorder (PTSD), depression, and increased systemic inflammation. However, it remains unknown whether childhood maltreatment and HIV interact to exacerbate PTSD, depression, and inflammation …
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