William J. Gibson

Interpretable Prediction of Ligand–Protein Binding without Protein Structural Information

Ananthan Sadagopan, Anurag Sodhi, William J. Gibson

Ligand-protein binding prediction remains a central challenge, yet the contribution of ligand-side information to performance is unclear. We combined pretrained molecular embeddings with TabPFNv2 to build per-target classifiers without protein features. Across 159 BindingDB targets, models assigned higher probabilities to annotated binders …

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Abstract B015: Clinical-stage ADC target enrichment across angiosarcoma anatomical subsets

Corrie Painter, Saud AlDubayan, Eliezer Van Allen, William J. Gibson

Abstract Background: Angiosarcoma (AS) is an anatomically heterogeneous ultra-rare sarcoma with no approved precision therapies. Head/face/neck/scalp (HNFS) AS is the only subset with reported immune checkpoint inhibitor activity. Whether AS subsets express clinically actionable antibody–drug conjugate (ADC) targets remains unclear. Methods: From …

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Erratum: Short- and Mid-term Outcomes of the Extravascular Implantable Cardioverter-defibrillator in Pediatric and Adolescent Patients: A Single-center Experience.

Nikola Dragisic, Emily R. Backes, Lindsey Malloy-Walton, Edo K. Bedzra et autres

[This corrects the article DOI: 10.19102/icrm.2025.16113.].

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Brief Communication: Personalized Circulating Tumor DNA as a Predictor of Pathologic Response in Neoadjuvant Treatment of Resectable Melanoma

Justine V. Cohen, Mofei Liu, Grace Rogers, Michael Manos et autres

Patients with resectable stage III-IV melanoma are at high risk of recurrence following surgical excision. Neoadjuvant therapy (NEO) with immune checkpoint inhibition (ICI) improves event-free survival and may allow for pathologic treatment response assessment with potential adjuvant therapy de-escalation. Identification of a …

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An epigenetic bifunctional that toggles between transactivation and repression

Ananthan Sadagopan, Maximilian Carson, Eriks J. Zamurs, Shanivi Srikonda et autres

The targeted modulation of gene expression with bifunctional small molecules enables the precise control of cellular and biological processes. To screen for ligands that could be used to induce gene expression, we conjugated the high affinity FKBP(F36V) binder, AP1867, to known high-affinity …

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Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity

Erica Pimenta, Amanda Garza, Sabrina Y. Camp, Jihye Park et autres

Sarcomas are rare cancers thought to arise from aberrant mesenchymal stem cell (MSC) differentiation. Liposarcoma (LPS) is among the most commonly diagnosed sarcomas and provides insights into dysfunctional differentiation through its well- and dedifferentiated subtypes (WDLPS and DDLPS). Despite differences in histology …

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Publisher Correction: Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs

Ananthan Sadagopan, Eriks J. Zamurs, Nicholas Garaffo, Heng-Jui Chang et autres

In the version of the article initially published, the x -axis label for Fig. 4e was “log 10 (concentration), pM” but should have been “log 10 (concentration), nM” and has now been corrected in the HTML and PDF versions of the article.

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Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs

Ananthan Sadagopan, Eriks J. Zamurs, Nicholas Garaffo, Heng-Jui Chang et autres

Abstract TP53 mutant cancers are associated with approximately half of cancer deaths. The most common mechanism of p53 inactivation involves missense mutations. Such mutations in TP53 result in a robust upregulation of the p53 protein. Here, we demonstrate an induced proximity approach …

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Short- and Mid-term Outcomes of the Extravascular Implantable Cardioverter-defibrillator in Pediatric and Adolescent Patients: A Single-center Experience.

Nikola Dragisic, Lindsey Malloy-Walton, Edo Bedzra, William J. Gibson et autres

Experience with the Aurora extravascular (EV) implantable cardioverter-defibrillator (ICD) (Medtronic, Minneapolis, MN, USA) remains limited among pediatric centers in contrast to its broader implantation in adults. We evaluated our single-center experience with the EV ICD as part of our standard ICD options …

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Tamoxifen induces PI3K activation in uterine cancer

Kirsten Kübler, Agostina Nardone, Shankara Anand, Daniel Gurevich et autres

Mutagenic processes and clonal selection contribute to the development of therapy-associated secondary neoplasms, a known complication of cancer treatment. The association between tamoxifen therapy and secondary uterine cancers is uncommon but well established; however, the genetic mechanisms underlying tamoxifen-driven tumorigenesis remain unclear. …

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Crushed by the Weight of VAD Decisions: A HCM-VAD Case Report:

Lavina Desai, R. Juhl, K. Garner, V. Benvenuto et autres

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23 RET mutated non-small cell lung cancer (NSCLC) in association with patients from central America

Leifei Chen, William J. Gibson, S Sanne, B Boulmay