Patrícia C. Braga

Proteinuria remission profiles in obesity-related kidney disease after bariatric surgery

Pedro Pereira, Patrícia C. Braga, João Pereira, Sofia Silva Pereira et autres

In a carefully phenotyped, nondiabetic cohort with obesity-related kidney dysfunction, bariatric surgery markedly reduced proteinuria and albuminuria despite stable estimated glomerular filtration rate. Higher preoperative albuminuria was associated with greater postoperative improvement, whereas a substantial subset-predominantly males with higher baseline eGFR-showed persistent …

pt, it (code pays fourni par la source)

Losartan Protects Against Radiation-Induced Testicular Damage by Modulating Oxidative Stress, Testosterone Levels, and Metabolic Profile

Maria Angélica Spadella, Rúben Moreira, Patrícia C. Braga, Agnaldo Bruno Chies et autres

Background/Objectives: Testicular dysfunction is a side effect of radiotherapy due to off-target damage. Germ cells are highly vulnerable. Although Sertoli and Leydig cells are more resistant, they are still affected, impairing spermatogenesis and steroidogenesis. With rising youth cancer rates, strategies to preserve …

br, pt, gb (code pays fourni par la source)

Untargeted Urinary Proteomics Uncovers Nephroprotective and Systemic Adaptations after Obesity Surgery-Induced Weight Loss

Pedro Pereira, David F. Carrageta, Bárbara Guerra‐Carvalho, Patrícia C. Braga et autres

High Resolution Image Download MS PowerPoint Slide Weight loss induced by bariatric surgery (BS) has a profound impact on several biological systems. This study aimed to identify urinary proteins reflecting kidney and systemic adaptations to weight loss in patients with obesity before …

pt (code pays fourni par la source)

Endothelial responses to angiogenic modulators highlight metabolic mechanisms underlying vascular dysfunction in preeclampsia

Priscila Rezeck Nunes, Julyane N. S. Kaihara, Fábio Rogério de Moraes, Ljubica Tasić et autres

INTRODUCTION: An elevated sFlt-1/PlGF ratio in preeclampsia (PE) directly impairs endothelial cell (EC) metabolism, leading to increased lactate dehydrogenase (LDH) release, lipid peroxidation, and mitochondrial dysfunction. This may reflect a distinct metabolite profile which correlates with systemic maternal metabolic dysregulation, as evidenced …

br, pt (code pays fourni par la source)

A Pharmacological Dose of Liraglutide Improves Mitochondrial Performance in Mouse Leydig Cells

Bruno Oliveira‐Lopes, Patrícia C. Braga, Pedro Fontes Oliveira, Marco Gouveia Alves et autres

Male fertility has declined over the years, partly due to metabolic disorders such as obesity and Type 2 diabetes. Antidiabetic drugs, including GLP-1 receptor agonists like liraglutide, are widely used to manage these conditions and aid in weight loss. Within the male …

pt (code pays fourni par la source)

Mitochondrial dysfunction and defective quality control mechanisms in the kidney are not reversed by high-fat diet withdrawal in early obese mice

Patrícia C. Braga, Rui Miguel Pinheiro Vitorino, Rita M. Ferreira, Mariana Marques et autres

High fat diet (HFD) induces glomerulopathy and proximal tubule injury. The precise pathophysiological mechanisms triggering obesity-related kidney impairment remain elusive, especially after dietary correction. Male C57BL6/J mice (n = 15) were divided in: control group (CTR) fed with standard chow; a group …

pt (code pays fourni par la source)

Metabolic profile of urine of albuminuric and non-albuminuric nephropathic diabetic patients suggests TCA-cycle related biomarkers

Patrícia C. Braga, Bárbara Guerra‐Carvalho, Manuela Almeida, Sofia Silva Pereira et autres

pt (code pays fourni par la source)

Determinants of Obesity-Related Kidney Dysfunction Remission after Bariatric Surgery

Patrícia C. Braga, João Pereira, Sofia Silva Pereira, Mário Caetano Nora et autres

pt (code pays fourni par la source)

How institutional support can accelerate the advancement of New approaches methodologies in biomedical research in Brazil: A workshop report

Lorena de Oliveira Neves, Patrícia C. Braga, Marília Zaluar P. Guimarães, Leila Bastos Leal et autres

• First Brazilian workshop on institutional strategies to advance NAMs. • Overview of Brazilian initiatives and international collaborations on NAMs. • Identifies barriers to NAM adoption and proposes cross-sectoral solutions. • Supports policy aligned with Brazil’s science agenda and global goals. • …

br, gb, ru, be, cz (code pays fourni par la source)

416.3: Exploring metabolic changes in living kidney donors before and after donation: A comparative analysis.

Patrícia C. Braga, Manuela Almeida, Barbara G Carvalho, Pedro Pereira et autres

Living donor (LD) kidney transplant represents the best treatment for end-stage renal disease, but the LD safety is paramount. After kidney donation, glomerular hyperfiltration ensues to compensate for kidney mass loss. Thus, we intend, by metabolic approach, to identify in donor urine …

pt (code pays fourni par la source)

Exposure to toxicologically relevant atrazine concentrations impair the glycolytic function of mouse Sertoli cells through the downregulation of lactate dehydrogenase

Daniela Gomes-Andrade, Bárbara Guerra‐Carvalho, David F. Carrageta, Raquel L. Bernardino et autres

Atrazine (ATZ), a widely used herbicide with potent endocrine-disrupting properties, has been implicated in hormonal disturbances and fertility issues. Sertoli cells (SCs) play a crucial role in providing mechanical and nutritional support of spermatogenesis. Herein, we aimed to study the effects of …

pt (code pays fourni par la source)

Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation

Joana L. Fernandes, Fátima O. Martins, Elena Olea, Jesús Prieto‐Lloret et autres

The association between obstructive sleep apnea (OSA) and metabolic disorders is well-established; however, the underlying mechanisms that elucidate this relationship remain incompletely understood. Since the liver is a major organ in the maintenance of metabolic homeostasis, we hypothesize that liver dysfunction plays …

pt, es (code pays fourni par la source)