Panpan Xu

Comparative transcriptome analysis unveils unique antiviral immune signatures of Rhinolophus pusillus

Lamei Zhao, Yelin Han, Yuyang Wang, Wenliang Zhao et autres

Background Rhinolophus pusillus is currently the only known horseshoe bat that simultaneously harbors SARS-CoV-related coronaviruses (SARSr-CoVs), SARS-CoV-2-related coronaviruses (SC2r-CoVs), and a sarbecovirus recombinant lineage with a mosaic genome combining features of both SARS-CoV and SARS-CoV-2. However, the molecular basis underlying multi-virus coexistence …

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Evolution of the Spatial transcriptomic landscape during the progression of high-grade pancreatic intraductal papillary mucinous neoplasms to invasive cancer

Sirui Peng, Qiangxing Chen, Zixin Chen, Mengling Yao et autres

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Characterization of Enterobacter sp. C2 and its impact on ginger metabolism and defense

Ke Qiang Huang, Panpan Xu, Xiangcheng Sun, Yi Tu et autres

Ginger (Zingiber officinale Roscoe), a globally significant medicinal and culinary crop, is increasingly threatened by soil-borne diseases, leading to substantial yield losses and economic damage. Although multiple pathogens contribute to these diseases, the involvement of Enterobacter species remains poorly characterized. In this …

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Dynamic Freight Order Allocation Optimization Under Carbon Tax Constraints in SAGIN: Multi‐Objective Optimization and Sustainability Assessment

B Liu, Panpan Xu, Song Sun, Changbing Jiang et autres

ABSTRACT With the advancement of low‐carbon economy and the emergence of Space‐Air‐Ground Integrated Network (SAGIN), carbon tax policies have become essential to driving sustainable optimization in freight industries operating within heterogeneous and dynamic network environments. This paper proposes a dynamic freight order …

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Risk Model Based On Neutrophil-Related Genes Constructs to Assess Prognosis and Immune Landscape in Diffuse Large B-Cell Lymphoma

Xinfang Gao, Xinguo Luo, Hongwei Ye, Shanshan Hu et autres

OBJECTIVES: Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma, represents a highly heterogeneous cancer. Neutrophils, as the core effector cells of intrinsic immunity, play an important role in regulating the tumor microenvironment (TME) due to their functional complexity. …

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ZOVER 2.0: a virome-based platform for zoonotic and vector-borne viruses

Bo Liu, Lin Zhu, Siyu Zhou, Aiyun Li et autres

Emerging zoonotic and vector-borne viruses pose a continuous threat to global public health, highlighting the need for effective virome surveillance that targets key wildlife reservoirs and vectors. Addressing this challenge requires a systematic understanding of both viral and host diversity, especially across …

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Uncovering Causal Relation Shifts in Event Sequences Under Out-of-Domain Interventions

Kazi Tasnim Zinat, Yun Zhou, Xiang Lyu, Y. Q. Wang et autres

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Drug selection based on pan-genomics genetic features of Mycobacterium tuberculosis

Xiangcheng Sun, Panpan Xu, Yun Cheng Shi, Ning Wang et autres

Tuberculosis, caused by Mycobacterium tuberculosis, is a severe and persistent global public health issue, particularly exacerbated by the emergence of multidrug-resistant and extensively drug-resistant strains. This study employed pan-genomic approaches to analyze different strains with various resistance profiles, examining the diversity of …

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Reconfigurable intelligent surface-aided secret key generation using an autoencoder and K-means quantization

Zeyu Li, Panpan Xu, Qiangqiang Gao, Chunguo Li et autres

In quasi-static wireless channel scenarios, the generation of physical layer keys faces the challenge of invariant spatial and temporal channel characteristics, resulting in a high key disagreement rate (KDR) and low key generation rate (KGR). To address these issues, we propose a …

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Vanillin restrains proliferation of triple negative breast cancer cells by inducing ferroptosis via mediating the KLF2/GPX4 axis

Jincheng Wang, Lei Zhang, Qingling Yang, Junjie Hu et autres

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Reprogramming tumor-associated macrophages and blocking PD-L1 via engineered outer membrane vesicles to enhance T cell infiltration and cytotoxic functions

Zhiqiang Chen, Bo Wang, Jianwei Zheng, Chao Liu et autres

The immunosuppressive tumor microenvironment (TME) critically undermines the efficacy of T cell-based tumor immunotherapy by impeding CD8 + T cell infiltration and cytotoxic function, primarily through tumor-associated macrophages (TAMs) and immune checkpoint molecules such as programmed death ligand 1 (PD-L1). Here, we …

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Uncovering Causal Relation Shifts in Event Sequences under Out-of-Domain Interventions

Kazi Tasnim Zinat, Yun Zhou, Xiang Lyu, Y. Q. Wang et autres

Inferring causal relationships between event pairs in a temporal sequence is applicable in many domains such as healthcare, manufacturing, and transportation. Most existing work on causal inference primarily focuses on event types within the designated domain, without considering the impact of exogenous …