Wen Pan

New Immunological Insights into Bisphosphonate-Related Osteonecrosis of the Jaw: A Multidimensional Reappraisal from Molecular Switches to Clinical Phenotypes

Yao Li, Shengao Qin, Jiaqi Wang, Zhaochen Shan et autres

Bisphosphonates (BPs) are cornerstone therapeutic agents for the management of metabolic bone disorders and skeletal complications associated with malignant tumors. However, their long-term administration is accompanied by the risk of developing bisphosphonate-related osteonecrosis of the jaw (BRONJ). In recent years, the pathogenesis …

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IL-34 Regulates Macrophage Polarization and Bone Defect Healing in Aged Mice

Wen Pan, Shengao Qin, Liu Zd, Yi-Xiang Wang et autres

Aging is a major risk factor for impaired bone-defect healing, and dysregulation of the immune microenvironment, especially macrophage dysfunction, is closely linked to this process. Interleukin-34 (IL-34) plays a crucial role in macrophage biology; however, its role in aging-related bone-defect healing remains …

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Inorganic nitrate attenuates neuroinflammation after traumatic brain injury via Sialin

Liang Hu, Qiaochu Wang, Xiang Zhao, Weiming Liu et autres

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Nanonitrator: Novel nano-composite formulation of inorganic nitrate enhancing body protective effects

Wen Pan, Geng Hu, Shaorong Li, Guoqing Li et autres

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Topical Application of Nitrate Ameliorates Skin Fibrosis by Regulating ST2+CD4+ T Cells in Systemic Sclerosis Mouse Model

Jianyu Gu, Zekun Zhou, Shihan Xu, Wen Pan et autres

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Nanonitrator: novel enhancer of inorganic nitrate’s protective effects, predicated on swarm learning approach

Wen Pan, Geng Hu, Shaorong Li, Guoqing Li et autres

Inorganic nitrate is an indispensable nutrient that has been used in experimental studies for the prevention and treatment of several diseases. However, the short half-life of nitrate limits its clinical application. To increase the usability of nitrate and overcome the challenges of …

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Dietary nitrate improves jaw bone remodelling in zoledronate‐treated mice

Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang et autres

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication that occurs in patients with osteoporosis or metastatic bone cancer treated with bisphosphonate. There is still no effective treatment and prevention strategy for BRONJ. Inorganic nitrate, which is abundant in green vegetables, …

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Nanonitrator: novel enhancer of inorganic nitrate’s protective effects, predicated on deep learning approach

Wen Pan, Geng Hu, Shaorong Li, Guoqing Li et autres

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