Edijs Vavers

Simultaneous Expression of Sigma‐1 Receptor and Tetraspanins Highlights Pathways of Receptor Sorting Into Extracellular Vesicles

Edijs Vavers, Sergei Kopanchuk, Santa Veikšina, Jolanta Jonane et autres

Sigma-1 receptor (Sig1R) is an endoplasmic reticulum (ER) chaperone protein involved in regulating ER function, cellular stress responses, and autophagy, and disturbed Sig1R function has been associated with neurodegenerative and neuropsychiatric disorders, including Alzheimer's disease and amyotrophic lateral sclerosis. Although Sig1R has …

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Hydroxymethylglutaryl‐CoA reductase activity is essential for mitochondrial β‐oxidation of fatty acids to prevent lethal accumulation of long‐chain acylcarnitines in the mouse liver

Edgars Liepinsh, Liga Zvejniece, Laura E. Clemensson, Melita Ozola et autres

BACKGROUND AND PURPOSE: Statins are competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR), and exert adverse effects on mitochondrial function, although the mechanisms underlying these effects remain unclear. We used a tamoxifen-induced Hmgcr-knockout (KO) mouse model, a multi-omics approach and mitochondrial …

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MultiBacMam Technology for Studying the Downstream cAMP Signaling Pathway of M2 Muscarinic Acetylcholine Receptor

Anni Allikalt, Santa Veikšina, Maris‐Johanna Tahk, Edijs Vavers et autres

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Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats

Liga Zvejniece, Baiba Švalbe, Edijs Vavers, Melita Ozola et autres

Long-chain acylcarnitines (LCACs) are intermediates of fatty acid oxidation and are known to exert detrimental effects on mitochondria. This study aimed to test whether lowering LCAC levels with the anti-ischemia compound 4-[ethyl(dimethyl)ammonio]butanoate (methyl-GBB) protects brain mitochondrial function and improves neurological outcomes after …

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Sigma-1 receptor and seizures

Edijs Vavers, Liga Zvejniece, Maija Dambrova

Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R ligands are underway testing therapies for the treatment of drug-resistant seizures, developmental and epileptic encephalopathies, …

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Moderate traumatic brain injury triggers long-term risks for the development of peripheral pain sensitivity and depressive-like behavior in mice

Gundega Stelfa, Baiba Švalbe, Edijs Vavers, Ilmārs Dūrītis et autres

As traumatic brain injury (TBI) is one of the major causes of permanent disability, there is increasing interest in the long-term outcome of TBI. While motor deficits, cognitive impairment and longer-term risks of neurodegenerative disease are well-established consequences in animal models of …

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Antidepressive-like Behavior-Related Metabolomic Signatures of Sigma-1 Receptor Knockout Mice

Baiba Švalbe, Baiba Zvejniece, Gundega Stelfa, Kārlis Vilks et autres

Sigma-1 receptor (Sig1R) has been proposed as a therapeutic target for neurological, neurodegenerative, and psychiatric disorders, including depression and anxiety. Identifying metabolites that are affected by Sig1R absence and cross-referencing them with specific mood-related behaviors would be helpful for the development of …

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Intracellular dynamics of the Sigma-1 receptor observed with super-resolution imaging microscopy

Sergei Kopanchuk, Edijs Vavers, Santa Veikšina, Kadri Ligi et autres

Sigma-1 receptor (Sig1R) is an endoplasmic reticulum (ER)-related membrane protein, that forms heteromers with other cellular proteins. As the mechanism of action of this chaperone protein remains unclear, the aim of the present study was to detect and analyze the intracellular dynamics …

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Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

Gundega Stelfa, Edijs Vavers, Baiba Švalbe, Rinalds Serzants et autres

Neuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral disabilities. The aim of our study was to evaluate the role of S1R …

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Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures

Edijs Vavers, Baiba Zvejniece, Gundega Stelfa, Baiba Švalbe et autres

There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute and chronic seizure models. However, the …

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Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury

Einārs Kupats, Gundega Stelfa, Baiba Zvejniece, Solveiga Grı̄nberga et autres

Altered neuronal Ca2+ homeostasis and mitochondrial dysfunction play a central role in the pathogenesis of traumatic brain injury (TBI). R-Phenibut ((3R)-phenyl-4-aminobutyric acid) is an antagonist of the α2δ subunit of voltage-dependent calcium channels (VDCC) and an agonist of gamma-aminobutyric acid B (GABA-B) …

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Inhibition of sigma-1 receptors substantially modulates GABA and glutamate transport in presynaptic nerve terminals

Natalia Pozdnyakova, Natalia V. Krisanova, Marina Dudarenko, Edijs Vavers et autres

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