Hanyi Jiang

Breathing bad: increased risk for obstructive sleep apnea in current and former smokers

Markus Krüger, Christiane Pink, Hanyi Jiang, Antoine Weihs et autres

Obstructive sleep apnea (OSA) and smoking are both prevalent and impactful health risks. While smoking may contribute to OSA through inflammatory and neuromuscular pathways, population-based evidence on this relationship remains limited and inconsistent. A sample (N = 1,206) from the population-based Study …

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Integrative multiomics analysis identifies RARRES2 as a regulator of keloid pathogenesis through STAT3/HSPG2 signaling axis

Wenkang Luan, Shujun Fan, Hanyi Jiang, Dongwen Jiang et autres

The molecular regulators behind the pathogenesis of keloid have not been fully determined. Through Mendelian randomization and multiomics analyses, we identified retinoic acid receptor responder 2 (RARRES2) as a causal risk factor for keloid. We further found that RARRES2 is mainly enriched …

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A prognostic model of patients with MDA5-positive dermatomyositis-associated interstitial lung disease: a multicenter retrospective cohort study in China

Ruyi Zou, Ping He, Hongxia Xin, Bin Xi et autres

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Effect of Decorin on Control of Lung and Heart Remodeling in BALB/c Mice Model of Allergic Asthma

Wenqiong He, Yan Xu, Ying Ma, Hanyi Jiang

Asthma is a chronic respiratory disease characterized by inflammation, airway remodeling, and fibrosis, which are critical aspects in its pathogenesis. TGF-β is a key regulator of these processes, promoting collagen deposition and fibrotic remodeling in the lungs and heart. Decorin (Dcn), an …

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The longitudinal effect of sleep apnea on changes in brain structure in a population-based sample

Antoine Weihs, Stefan Frenzel, Katharina Wittfeld, Hanyi Jiang et autres

STUDY OBJECTIVES: Increasing evidence points towards sleep apnea as a modifiable risk factor for neurodegeneration. This study investigates the longitudinal effect of sleep apnea on brain structures in a general population. METHODS: Data from the Study of Health in Pomerania with baseline …

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Surgical Management of Severe Congenital Ptosis: A Systematic Review

Hanyi Jiang, Zhiwei Chen, Yilue Zheng, Chanyuan Jiang et autres

OBJECTIVE: Severe congenital ptosis, primarily caused by levator palpebrae superioris (LPS) underdevelopment, may impair visual development and facial aesthetics. Although multiple surgical techniques exist, optimal procedure selection and long-term outcomes remain debated. METHODS: A systematic review was conducted following PRISMA guidelines. The …

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BACH1 is stabilized by vitamin E and attenuates the formation of hypertrophic scar through the Wnt/β-catenin pathway

Wenkang Luan, Hanyi Jiang, Dongwen Jiang, Jinxiu Yang et autres

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circDCBLD2 regulates the Th1/Th2 immune balance via the miR-26a-5p/PTEN axis

Yue Zhao, Rui Li, Shuting Yu, Beibei Zhu et autres

Asthma is a prevalent chronic respiratory disease in children. Recently, adjusting the Th1/Th2 imbalance has become a significant focus in asthma immunotherapy. The present study aims to investigate the roles and mechanisms of circDCBLD2 in maintaining the Th1/Th2 immune balance. CircDCBLD2 is …

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IL-6 signaling is required for the development and regeneration of ear cartilage in microtia

Wenkang Luan, Hanyi Jiang, Dongwen Jiang, Jinxiu Yang et autres

Introduction Congenital microtia is a birth defect characterized by auricular underdevelopment, with unclear pathogenesis and unidentified pathogenic genes. Methods Differential expression analysis, weighted co-expression network analysis (WGCNA), protein-protein interaction (PPI) networks and support vector machine recursive feature elimination (SVM-RFE) identified the key …

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External validation of the 2017 EULAR/ACR classification criteria for idiopathic inflammatory myopathies in anti-MDA5 antibody-positive interstitial lung disease patients: A multicenter retrospective cohort study in China

Bi Chen, Hongquan Xin, Ruyi Zou, Yaqiong Tian et autres

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Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis

Yaqiong Tian, Xuan Zhou, Mi Tian, Lijun Ren et autres

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis, nomogram model for its prognosis and acute exacerbation was constructed. METHODS: Two hundred and sixty eight patients with IPF were grouped with different severity according to fibrosis area, …

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Clinical features and risk factors of invasive pulmonary aspergillosis in interstitial lung disease patients

Yin Liu, Hanyi Jiang, Tingting Zhao, Min Cao et autres

BACKGROUND: The prevalence of invasive pulmonary aspergillosis (IPA) among patients with interstitial lung disease (ILD) is steadily increasing, leading to high mortality. The purpose of this study is to analyze the clinical features and risk factors of IPA in patients with ILD. …

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