Markus A Heilig

Identification and validation of central amygdala FGFR1 as a therapeutic target for alcohol use disorder using single-nucleus sequencing in rats

Estelle Barbier, Leon Höglund, Li Xin Xu, Nihal A. Salem et autres

A significant minority of alcohol users develop alcohol addiction, characterized by continued use despite negative consequences, referred to as compulsive-like. We previously showed that vulnerability to compulsive-like alcohol use can be modeled in rats using punished alcohol self-administration and in male rats …

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Effects of psychosocial stress on opioid self-administration in healthy participants: a randomized, placebo-controlled crossover trial

Marie Eikemo, Guro E. Løseth, Molly Carlyle, Martin Trøstheim et autres

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Global changes in gene expression and splicing in alcoholic liver disease

Ilya O. Blokhin, Derek Van Booven, Josepmaria Argemí, Mengying Li et autres

Alcohol use disorder is a widespread illness commonly leading to alcoholic liver disease (ALD) and cirrhosis with an increased incidence of hepatocellular carcinoma (HCC), but the mechanisms of alcohol-related oncogenesis in the liver are incompletely understood. We tested the hypothesis that ALD …

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374. Does Morphine Buffer Against the Adverse Reactions of Simulated Social Exclusion? - A Randomized Controlled Experimental Medical Trial

Anton Käll, Andreas Löfberg, Irene Perini, Robin Kämpe et autres

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The role of proinflammatory response and the kynurenine pathway in the association between childhood maltreatment and lifetime substance use disorder

Lars Östman, Elisabeth R. Paul, He Zhang, Evelina Larsson et autres

Introduction: Childhood maltreatment (CM) is a risk factor for adult psychiatric and substance use disorders (SUD). Retrospectively assessed CM has been linked to increased proinflammatory cytokines, including IL-6. Induced by inflammation, the neurotoxic branch of the kynurenine pathway has been implicated in …

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Single nucleus RNA sequencing identifies Fgf-R1 signaling in central amygdala as a neural substrate of punishment-resistant alcohol self-administration

Markus A Heilig, Estelle Barbier, Leon Höglund, Li Xu et autres

Functional neuroimaging of fatty acid amide hydrolase inhibition in posttraumatic stress disorder: a randomized clinical trial

Ryann C. Tansey, Irene Perini, Gavin N. Petrie, Connor J. Haggarty et autres

The endocannabinoid ligand anandamide (AEA) plays a role in fear extinction, the conceptual foundation of the gold standard treatment for posttraumatic stress disorder (PTSD), exposure-based psychotherapy. Converging evidence from animal models and non-clinical human studies highlights the potential to enhance fear extinction …

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Individual and additive effects of childhood maltreatment and substance use disorder histories on baseline and stress-induced changes in peripheral stress biomarkers

Abigail R. Lunge, Ryann C. Tansey, Daniel Roche, Elisabeth R. Paul et autres

BACKGROUND: Exposure to childhood maltreatment (CM) has serious consequences on the health of affected individuals, potentially elevating vulnerability to various psychopathologies, including substance use disorders (SUDs). Recent investigations have implicated several biological signaling systems in vulnerability to SUD development following CM, including …

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Toward Inclusive, Evidence-Based rTMS Care for Patients With Co-Occurring Substance Use Disorders.

Vaughn R. Steele, Merideth A. Addicott, Giovanni Addolorato, Travis E. Baker et autres

Contains fulltext : 327173.pdf (Publisher’s version ) (Closed access)

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Immune and metabolic disturbance as a function of genetic risk and phase of illness in major depression

David M. Howard, Lachlan Gilchrist, Petroula Proitsi, Elisabeth R. Paul et autres

Immune and metabolic factors are important in the pathophysiology of major depressive disorder (MDD) but we know little about how these factors manifest in relation to the status of depressive illness-from genetic risk for MDD, to a depressive episode, to depression in …

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Can you feel it? Altered affective touch perception in a transdiagnostic sample of female adolescents with nonsuicidal self-injury

Maria Zetterqvist, Magnus Olofsson, Håkan Olausson, Martin P. Paulus et autres

Nonsuicidal self-injury (NSSI), intentionally inflicting harm to one's body without suicidal intent, is a significant mental health problem in adolescents. Biological mechanisms underlying NSSI are still not well understood but there is some support for altered pain sensitivity. Here we explored the …

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Potential TMS biomarkers for GABA B receptor engagement in alcohol use disorder: A systematic review of existing evidence

Chiara Montemitro, Sara Terrezza, Federico Maruottolo, Andrea Costumati et autres

Abstract Alcohol use disorder (AUD) is a major global health issue, with current treatments often limited in efficacy and patient acceptance. The gamma‐aminobutyric acid (GABA) system, particularly GABA B receptors (GABA B R), is crucial in the pathophysiology of AUD. This review …

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