Maria Del Ben

Development of nutritionally enhanced sourdough bread through Tritordeum bran incorporation and assessment in an in vitro gut simulation

Bilal Sajid Mushtaq, Olga Nikoloudaki, Maria Del Ben, Kashika Arora et autres

• First study on Tritordeum –bran sourdough breadmaking using defined starters. • Fermentation improved bread nutrition, reducing phytic acid and glycemic index. • Sourdough bread with bran was nutritionally superior to baker’s yeast bread. • SHIME Ⓡ showed bran sourdough bread supported …

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An organotypic model of ductular reaction reveals a mevalonate-dependent vulnerability in reactive biliary cells

Beatrice Anfuso, Suresh Velnati, Davide Selvestrel, Clara Garlant et autres

Chronic liver injury is marked by the emergence of ductular reaction (DR), where reactive biliary epithelial cells (BECs) proliferate and engage in multicellular networks, driving disease progression. Despite its clinical relevance, the mechanisms underlying DR activation remain elusive, partly due to the …

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Platelet Thromboxane B2 overproduction associated with liver fibrosis severity in patients with MASLD

Francesco Baratta, Nicholas Cocomello, Guido Carpino, Alessandra Colantoni et autres

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Aging and IGF-I: relationships with vitamin D and body composition. A mediation analysis

Roberto Vicinanza, Alessandro Frizza, Valentina Mazza, Giovanni Imbimbo et autres

Background Insulin-like Growth Factor I (IGF-I) and Vitamin D are crucial for growth and metabolism, with their levels declining with age. However, their mutual interactions and contributions to body composition remain unclear. Objectives To examine the relationships between IGF-I, Vitamin D, and …

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Lipid-Lowering Therapy and Cardiovascular Prevention in Elderly

Francesco Baratta, Federica Moscucci, Ilaria Lospinuso, Nicholas Cocomello et autres

The global population aged 80 years and older will reach approximately half a billion in the coming years, and cardiovascular prevention in this group of patients will become a global health challenge. In the era of evidence-based medicine, the use of lipid-lowering …

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Dark chocolate's impact on low-grade endotoxemia in metabolic dysfunction-associated steatohepatitis

Arianna Pannunzio, Francesco Baratta, Enrico Maggio, Ilaria Palumbo et autres

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A diagnosis too far: chronic lymphocytic leukemia, neurosarcoidosis, motor neurone disease

Freiha Joumana, Grand Effie, Maria Del Ben, A. Rama et autres

Sarcoid like reaction is a rare autoinflammatory disease that can affect lymph nodes and organs but does not meet the diagnostic criteria for systemic sarcoidosis. Anti-CD20 auto- antibodies have been reported to be responsible for such reactions. Although very rare, there has …

Effects of sulphur thermal water inhalations in long-COVID syndrome: Spa-centred, double-blinded, randomised case–control pilot study

Serena Crucianelli, Alessia Mariano, Nicholas Cocomello, Gianluca Gianfranceschi et autres

The long-COVID syndrome is characterised by a plethora of symptoms. Given its social and economic impact, many studies have stressed the urgency of proposing innovative strategies other than hospital settings. In this double-blinded, randomised, case–control trial, we investigate the effects of sulphur …

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Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study

Amany Elshorbagy, Alexander R.M. Lyons, Antonio J. Vallejo‐Vaz, Christophe Stevens et autres

BACKGROUND: Statins are the cornerstone treatment for patients with heterozygous familial hypercholesterolaemia but research suggests it could increase the risk of type 2 diabetes in the general population. A low prevalence of type 2 diabetes was reported in some familial hypercholesterolaemia cohorts, …

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Epicardial fat and liver stiffness by acoustic radiation force impulse elastography in people with HIV-1 infection without liver disease

Daniele Pastori, Francesco Del Sole, Tommaso Brogi, Maria Del Ben et autres

OBJECTIVE: To evaluate the association between increased epicardial fat thickness (EFT) and liver stiffness measurement (LSM), as assessed by elastography in people with human immunodeficiency virus type 1 (HIV-1) infection (PWH). METHODS: Ninety-one PWH on effective antiretroviral treatment (ART) were enrolled. EFT …

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Impact of Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i) Therapy on Dementia and Cognitive Decline

Antonio Lardaro, L. Quarta, Stefania Pagnotta, Giorgio Sodero et autres

Dementia is an age-related syndrome characterized by the progressive deterioration of cognition and capacity for independent living. Diabetes is often associated with cognitive decline and shares similar pathophysiological mechanisms with dementia, such as systemic inflammation, oxidative stress, insulin resistance, and advanced glycation …

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Liver fibrosis progression and lysosomal acid lipase activity in patients with Metabolic-Associated Steatotic Liver Disease

Alessandra Colantoni, Daniele Pastori, Nicholas Cocomello, Francesco Angelico et autres