Angelo Musicò

Biomolecular Corona of Extracellular Vesicles: Report on Isev Workshop

Lucia Paolini, Selene Tassoni, Khuloud T. Al‐Jamal, Xavier Banquy et autres

The concept of the "biomolecular corona" (BC) was first introduced to describe the spontaneous absorption of molecules, mainly proteins, onto the surface of synthetic nanoparticles upon exposure to biological fluids. More recently, the same term has been used to describe biomolecules that …

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Red blood cell-derived extracellular vesicles as biomaterials: the opportunity of freezing-induced accelerated aging

Lucia Paolini, Miriam Romano, Valentina Mangolini, Selene Tassoni et autres

Red blood cell-derived extracellular vesicles (RBC-EVs) are emerging as promising biomaterials for next-generation drug delivery, owing to their intrinsic biocompatibility, immune-evasion properties, and minimal oncogenic risk. However, their broader application is currently limited by unresolved challenges related to heterogeneity, reproducibility, and long-term …

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Red blood Cell-derived Extracellular Vesicles as biomaterials: the opportunity of freezing-induced accelerated aging

Lucia Paolini, Miriam Romano, Valentina Mangolini, Selene Tassoni et autres

Abstract Red blood cell-derived extracellular vesicles (RBC-EVs) are emerging as promising biomaterials for next-generation drug delivery, due to their inherent biocompatibility, immune evasion capabilities, and minimal oncogenic risk. However, their clinical translation remains limited by unresolved challenges related to heterogeneity, reproducibility, and …

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Orthogonal investigation at single-particle and ensemble levels uncovers lipoprotein-extracellular vesicle binding

Angelo Musicò, Roberto Frigerio, Karl Normak, Sabrina Scolari et autres

Mesoscale interactions—such as biomolecular coronas, transient associations, aggregation, and fusion—are increasingly recognized for their biological significance and, under certain conditions, are essential for extracellular nanoparticles to fulfill their functions. Among these interactions, the binding between extracellular vesicles and lipoproteins has recently gained …

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Red Blood Cell-derived Extracellular Vesicles enable Cisplatin and Cetuximab combined Therapy against Triple-Negative Breast Cancer

Miriam Romano, Angelo Musicò, Andrea Zendrini, Enrica Gilberti et autres

Background: Triple-negative breast cancer is an aggressive breast cancer subtype characterized by the absence of human epidermal growth factor receptor 2, estrogen and progesterone receptors, limiting targeted therapy options. Cisplatin, a chemotherapeutic agent, induces DNA damage and exhibits some efficacy against triple-negative …

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Extracellular vesicles of different cellular origin feature distinct biomolecular corona dynamics

Angelo Musicò, Andrea Zendrini, Santiago Giménez Reyes, Valentina Mangolini et autres

under physiological conditions. Results evidence that the two extracellular vesicle populations feature distinct corona dynamics. These findings indicate that the dynamics of the biomolecular corona may ultimately be linked to the cellular origin of the extracellular vesicles, revealing an additional level of …

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Author response for "Extracellular vesicles of different cellular origin feature distinct biomolecular corona dynamics"

Angelo Musicò, Andrea Zendrini, Santiago Giménez Reyes, Valentina Mangolini et autres

Extracellular vesicles of different cellular origin feature distinct biomolecular corona dynamics

Angelo Musicò, Andrea Zendrini, Santiago Giménez Reyes, Valentina Mangolini et autres

Initially observed on synthetic nanoparticles, biomolecular corona existence and role in determining nanoparticle identity and function are now beginning to be acknowledged in biogenic nanoparticles, particularly in extracellular vesicles. We have developed here a methodology based on Fluorescence Correlation Spectroscopy to track …

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Extracellular vesicles derived from mesenchymal stromal cells and red blood cells feature distinct biomolecular corona dynamics

Angelo Musicò, Andrea Zendrini, Santiago Giménez Reyes, Valentina Mangolini et autres

The Biomolecular Corona (BC) is a typical phenomenon that occurs at the interface between the nanomaterial and the surrounding media, involving the adsorption or the desorption of macromolecules at this interface. Studying BC dynamic properties on soft nanomaterials (i.e., liposomes or extracellular …

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Extracellular vesicles derived from mesenchymal stromal cells and red blood cells feature distinct biomolecular corona dynamics

Angelo Musicò, Andrea Zendrini, Santiago Giménez Reyes, Valentina Mangolini et autres

The Biomolecular Corona (BC) is a typical phenomenon that occurs at the interface between the nanomaterial and the surrounding media, involving the adsorption or the desorption of macromolecules at this interface. Studying BC dynamic properties on soft nanomaterials (i.e., liposomes or extracellular …

it, ar, es (code pays fourni par la source)

Extracellular vesicles derived from mesenchymal stromal cells and red blood cells feature distinct biomolecular corona dynamics

Angelo Musicò, Andrea Zendrini, Santiago Giménez Reyes, Valentina Mangolini et autres

The Biomolecular Corona (BC) is a typical phenomenon that occurs at the interface between the nanomaterial and the surrounding media, involving the adsorption or the desorption of macromolecules at this interface. Studying BC dynamic properties on soft nanomaterials (i.e., liposomes or extracellular …

it, ar, es (code pays fourni par la source)

Extracellular vesicle analysis in supramolecular 3D hydrogels: a proof-of-concept

Greta Bergamaschi, Roberto Frigerio, Angelo Musicò, Giulia Lodigiani et autres

Here we report a proof-of-concept application of a composite Aga-Q3 hydrogel for the gentle confinement and analysis of extracellular vesicles (EVs) on microarray analytical platforms.

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