A. Shiozawa

48 Small airway epithelial cells in M. abscessus infection: Implications for inflammation and epithelial barrier integrity

A. Shiozawa, Gillian Crisp, Hiroki Murano, Scott H. Randell et autres

91 N-acetylcysteine mediates protection against Mycobacterium avium by restoring suppressed autophagy in host alveolar type 1 epithelial cells

A. Shiozawa, Chiaki Kajiwara, K.N. Olivier, Kazuhiro Tateda

Intermittent Versus Daily Treatment for Noncavitary Nodular Bronchiectatic Mycobacteria Avium Complex Lung Disease With Rifampicin, Ethambutol, and Clarithromycin (iREC): An Open-label, Multicenter, Randomized Controlled Trial

Kohei Fujita, Taku Nakagawa, Mari Miki, Akihiro Ito et autres

jp (code pays fourni par la source)

Postoperative Management of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps: Impact of High-Dose Corticosteroid Nasal Spray

Katsuhisa Ikeda, Shin Ito, Remi Hibiya, Hirotomo Homma et autres

Introduction Eosinophilic chronic rhinosinusitis (ECRS) is characterized by an eosinophilic inflammation driven by Th2-type cytokines. Glucocorticosteroids are the most common first-line treatment for ECRS with nasal polyps. Objective We have evaluated the long-term treatment with double-dose intranasal corticosteroids in refractory ECRS nasal …

jp (code pays fourni par la source)

Complications of Short-Course Oral Corticosteroids for Eosinophilic Chronic Rhinosinusitis during Long-Term Follow-Up

Remi Motegi, Shin Ito, Hirotomo Homma, Noritsugu Ono et autres

The literature strongly recommends the use of oral corticosteroids in the management of patients with eosinophilic chronic rhinosinusitis (CRS) with nasal polyps. Although potential complications associated with the long-term use of oral corticosteroids for the treatment of CRS have been suggested, no …

jp (code pays fourni par la source)

Orbital Injury in Endoscopic Sinus Surgery for Sinonasal Inflammatory Disorders: Juntendo’s Ten-Year Experience

Katsuhisa Ikeda, Shin Ito, Hirotomo Homma, Noritsugu Ono et autres

Orbital injury and complications are commonly encountered in endoscopic sinus surgery (ESS) despite advances in techniques and instrumentation. For the recent 10 years, we summarized the experience of the rhinology unit of our department regarding orbital injury and complications of ESS for …

jp (code pays fourni par la source)

Endonasal Endoscopic Anterior Skull Base Surgery for Sinonasal Malignancies: Juntendo’s Experience

Katsuhisa Ikeda, Shin Ito, Hirotomo Homma, Noritsugu Ono et autres

Endoscopic sinus surgery is widely accepted as a primary surgical modality for the treatment of inflammation, trauma, benign tumors, and fibro-osseous lesions. Recent advances in instrumentation, surgical navigation, and skull base reconstruction have enabled endoscopic skull base surgery to emerge as a …

jp (code pays fourni par la source)

Comparative analysis of cytokine release from epithelial cell cultures of the upper airway

A. Shiozawa, Masato Miwa, Noritsugu Ono, Hirotomo Homma et autres

Introduction: Upper airway epithelial cells show a multi-potential ability to produce a variety of cytokines/chemokines in the steady-state and under external stimuli. Objective: To compare various cytokines/chemokines released from primary cultures of human nasal epithelial cells (HNECs) derived from healthy controls and …

jp (code pays fourni par la source)

Comparative analysis of cytokine release from epithelial cell cultures of the upper airway

A. Shiozawa, Masato Miwa, Noritsugu Ono, Hiroaki Homma et autres

INTRODUCTION: Upper airway epithelial cells show a multi-potential ability to produce a variety of cytokines/chemokines in the steady-state and under external stimuli. OBJECTIVE: To compare various cytokines/chemokines released from primary cultures of human nasal epithelial cells (HNECs) derived from healthy controls and …

jp (code pays fourni par la source)

Fungal extracts detected in eosinophilic chronic rhinosinusitis induced cytokines from the nasal polyp cells

Mikio Hirotsu, A. Shiozawa, Noritsugu Ono, Masato Miwa et autres

OBJECTIVES/HYPOTHESIS: The role of fungi in chronic rhinosinusitis (CRS) is still controversial. The present study was conducted to detect and identify fungal species from the nasal polyp tissues of eosinophilic and noneosinophilic CRS, and to determine the role of fungal antigens in …

jp (code pays fourni par la source)

Subclassification of chronic rhinosinusitis with nasal polyp based on eosinophil and neutrophil

Katsuhisa Ikeda, A. Shiozawa, Noritsugu Ono, Takeshi Kusunoki et autres

OBJECTIVES/HYPOTHESIS: Japanese patients with chronic rhinosinusitis with nasal polyps (CRSwNP), differing from European and U.S. patients, are suggested to show two distinct phenotypes: Th2-polarized and Th1-shifted immunity. The purpose of this study was to conduct clinical subgrouping of CRSwNP based on inflammatory …

jp (code pays fourni par la source)

Reduction in Superoxide Dismutase Expression in the Epithelial Mucosa of Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Noritsugu Ono, Takeshi Kusunoki, Masato Miwa, Mikio Hirotsu et autres

BACKGROUND: Eosinophils generate large amounts of oxidant species. The eosinophil-dominant type of chronic rhinosinusitis (CRS) with nasal polyps is related to more extensive disease and a decreased likelihood of surgical success. Superoxide dismutase (SOD) is the first-line and only antioxidant enzyme that …

jp (code pays fourni par la source)