Alycia G. Berman

Photocurable extracellular matrix sealant for cessation of venous hemorrhage

Luke E. Schepers, Brooke L. Martindale, Alycia G. Berman, Hannah L. Cebull et autres

Hemorrhage is the second leading cause of death in patients under 46 years of age in the United States. Cessation of hemorrhage prevents hemorrhagic shock and tissue hypoxia. Controlling the bleed via direct pressure or tourniquet is often the first line of …

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Raloxifene Stimulates Estrogen Signaling to Protect Against Age- and Sex-Related Intervertebral Disc Degeneration in Mice

Neharika Bhadouria, Alycia G. Berman, Joseph Michael Wallace, Nilsson Holguin

Estrogen agonist raloxifene is an FDA-approved treatment of osteoporosis in postmenopausal women, which may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that 1) aging and biological sex contribute to IVD degeneration by reducing estrogen signaling …

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Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition

Alycia G. Berman, Daniel J. Romary, Katherine E. Kerr, Natalyn E. Gorazd et autres

Abdominal aortic aneurysm (AAA) formation and expansion is highly complex and multifactorial, and the improvement of animal models is an important step to enhance our understanding of AAA pathophysiology. In this study, we explore our ability to influence aneurysm growth in a …

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Nuclear deformation guides chromatin reorganization in cardiac development and disease

Benjamin Seelbinder, Soham Ghosh, Stephanie Ellyse Schneider, Adrienne K. Scott et autres

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Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement

Dar Weiss, Marcos Latorre, Bruno V. Rego, Cristina Cavinato et autres

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Raloxifene reduces sex- and age-related intervertebral disc degeneration in mice by estrogen signaling

Neharika Bhadouria, Paul Niziolek, Omar El Jordi, Alycia G. Berman et autres

Abstract Estrogen agonist raloxifene is an FDA-approved treatment for osteoporosis in postmenopausal women that may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that raloxifene would augment IVD structure and reduce neurokinin-1 (substance P) in young …

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Effects of Raloxifene and tibial loading on bone mass and mechanics in male and female mice

Alycia G. Berman, John George Damrath, Jennifer M. Hatch, Alexis N. Pulliam et autres

Purpose: Raloxifene (RAL) is a selective estrogen receptor modulator (SERM) that has previously been shown to cause acellular benefits to bone tissue. Due to these improvements, RAL was combined with targeted tibial loading to assess if RAL treatment during periods of active …

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Tissue‐Engineered Vascular Grafts: Effects of Braiding Parameters on Tissue Engineered Vascular Graft Development (Adv. Healthcare Mater. 24/2020)

Jacob C. Zbinden, Kevin M. Blum, Alycia G. Berman, Abhay B. Ramachandra et autres

In article number 2001093 by Jacob C. Zbinden, Christopher K. Breuer, and co-workers, tissue engineered arterial grafts are created from braided poly(glycolic acid) fibers at the boundaries of the manufacturable design space with and without a poly(glycerol sebacate) coating and evaluated in …

Effects of Braiding Parameters on Tissue Engineered Vascular Graft Development

Jacob C. Zbinden, Kevin M. Blum, Alycia G. Berman, Abhay B. Ramachandra et autres

Tissue engineered vascular grafts (TEVGs) using scaffolds fabricated from braided poly(glycolic acid) (PGA) fibers coated with poly(glycerol sebacate) (PGS) are developed. The approach relies on in vivo tissue engineering by which neotissue forms solely within the body after a scaffold has been …

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6′-Methoxy Raloxifene-analog enhances mouse bone properties with reduced estrogen receptor binding

Katherine M. Powell, Alexa P. Brown, Cayla Skaggs, Alexis N. Pulliam et autres

Raloxifene (RAL) is an FDA-approved drug used to treat osteoporosis in postmenopausal women. RAL suppresses bone loss primarily through its role as a selective estrogen receptor modulator (SERM). This hormonal estrogen therapy promotes unintended side effects, such as hot flashes and increased …

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Muscle contraction induces osteogenic levels of cortical bone strain despite muscle weakness in a mouse model of Osteogenesis Imperfecta

Alycia G. Berman, Jason M. Organ, Matthew R. Allen, Joseph Michael Wallace

Abstract Mechanical interactions between muscle and bone have long been recognized as integral to bone integrity. However, few studies have directly measured these interactions within the context of musculoskeletal disease. In this study, the osteogenesis imperfecta murine model (oim/oim) was utilized because …

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Muscle contraction induces osteogenic levels of cortical bone strain despite muscle weakness in a mouse model of Osteogenesis Imperfecta

Alycia G. Berman, Jason M. Organ, Matthew R. Allen, Joseph Michael Wallace

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