Weixiang Song

Exosomes-Transferred lncRNA H19 Reverses Osimertinib Resistance by Upregulating PTEN via Sponging miR-148-3p in Non-Small Cell Lung Cancer

Weixiang Song, Yanbo Zhang, Xubo Shen, Qin Yu et autres

Objective: Osimertinib can selectively inhibit both epidermal growth factor receptor (EGFR) sensitizing and T790M gatekeeper mutations, and has shown remarkable therapeutic effects in patients with lung adenocarcinoma. However, almost all patients inevitably develop drug resistance. Herein, we sought to clarify the roles …

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Left Atrial Fibrosis Amelioration Following Cardioversion Assessed with LGE-MRI in Patients with Persistent Atrial Fibrillation

Fang Qin, Y.-W Chen, Tianli Xia, Danni Liu et autres

Abstract Background Previous studies have demonstrated that cardioversion of atrial fibrillation may alleviate atrial remodeling. We aimed to investigate whether left atrial (LA) tissue fibrosis assessed by LGE-MRI, may be reversed after conversion of persistent atrial fibrillation (PersAF) to sinus rhythm. Methods …

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GPT-4 vs. radiologists: who advances mediastinal tumor classification better across report quality levels? a cohort study

Ru Wen, Xiaoming Li, Kang Chen, Mo Sun et autres

BACKGROUND: Accurate mediastinal tumor classification is crucial for treatment planning, but diagnostic performance varies with radiologists' experience and report quality. PURPOSE: To evaluate generative pretrained transformer's (GPT-4's) diagnostic accuracy in classifying mediastinal tumors from radiological reports compared to radiologists of different experience …

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Potentiating dual-directional immunometabolic regulation with nanomedicine to enhance anti-tumor immunotherapy following incomplete photothermal ablation

Qinqin Jiang, Bin Qiao, Jun Zheng, Weixiang Song et autres

Photothermal therapy (PTT) is a promising cancer treatment method due to its ability to induce tumor-specific T cell responses and enhance therapeutic outcomes. However, incomplete PTT can leave residual tumors that often lead to new metastases and decreased patient survival in clinical …

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Bronchial artery chemoembolization in the treatment of refractory central lung cancer with atelectasis

Yujin Liu, Xiumei Zhang, Fenxiang Zhang, Weixiang Song

Objective: This study aims to explore the clinical application of bronchial artery chemoembolization (BACE) in managing refractory central lung cancer with atelectasis. Methods: The retrospective case series includes patients diagnosed with refractory central lung cancer and atelectasis who underwent BACE treatment at …

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Regulation of spermatogonial stem cell differentiation by Sertoli cells‐derived exosomes through paracrine and autocrine signaling

Hairui Tian, Xingju Wang, Xiaoxiao Li, Weixiang Song et autres

In the orchestrated environment of the testicular niche, the equilibrium between self-renewal and differentiation of spermatogonial stem cells (SSCs) is meticulously maintained, ensuring a stable stem cell reserve and robust spermatogenesis. Within this milieu, extracellular vesicles, specifically exosomes, have emerged as critical …

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Live birth of chimeric monkey with high contribution from embryonic stem cells

Jing Cao, Wenjuan Li, Jie Li, Md. Abdul Mazid et autres

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Nonspecific intraventricular conduction delay predicts the prognosis of dilated cardiomyopathy

Yong Yuan, Kai Yang, Qianjun Liu, Weixiang Song et autres

PURPOSE: Left bundle branch block (LBBB) has been confirmed to be independently associated with adverse outcomes in dilated cardiomyopathy (DCM). However, prognostic data on nonspecific intraventricular conduction delay (NSIVCD) are still limited and conflicting. We aimed to evaluate the prognosis of DCM …

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Powell lens-based line-field spectral domain optical coherence tomography system for cellular resolution imaging of biological tissue

Keyu Chen, Weixiang Song, Le Han, Kostadinka Bizheva

A Powell lens is used in a line-field spectral domain OCT (PL-LF-SD-OCT) system to generate a line-shaped imaging beam with almost uniform distribution of the optical power in the line direction. This design overcomes the severe sensitivity loss (∼10 dB) observed along …

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Powell lens-based line-scan SD-OCT

Keyu Chen, Weixiang Song, Le Han, Kostadinka Bizheva

Traditionally, line scan OCT (LS-OCT) systems use a cylindrical lens to generate a line-shaped beam with Gaussian intensity illumination along the line, which leads to spatially-dependent signal-to-noise ratio (SNR) distribution of the OCT system along the B-scan direction. A novel, Powell lens-based …

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A systematic analysis of the global and regional burden of colon and rectum cancer and the difference between early- and late-onset CRC from 1990 to 2019

Liu-Bo Li, Liyu Wang, Daming Chen, Yingxia Liu et autres

The burden of colorectal cancer (CRC) varies substantially across different geographical locations. However, there was no further quantitative analysis of regional social development and the disease burden of CRC. In addition, the incidence of early- and late-onset CRC has increased rapidly in …

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Powell Lens-based Spectral Domain Line-Field Optical Coherence Tomography system for cellular resolution imaging of biological tissue

Kostadinka Bizheva, Keyu Chen, Weixiang Song, Le Han

A Powell lens is used in a Line-Field Spectral Domain OCT (PL-LF-SD-OCT) system to generate a line-shaped imaging beam with almost uniform distribution of the optical power in the line direction. This design overcomes the severe sensitivity loss (~10 dB) observed along …

ca (code pays fourni par la source)