Anne-Laure Lainé

Abstract 3929: Identification of MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD) for the treatment of cancers with Myc-induced translational addiction

Gérald Gavory, Mahmoud Ghandi, Anne-Cecile d’Alessandro, Débora Bonenfant et autres

Abstract Myc transcription factors are well-established drivers of human cancers. However, despite being amongst the most frequently mutated, translocated and overexpressed oncogenes, no therapy targeting the Myc family members directly has been developed to date. To sustain uncontrolled cell proliferation and tumor …

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Abstract LBA004: Identification of GSPT1-directed molecular glue degrader (MGD) for the treatment of Myc-driven breast cancer

Gérald Gavory, Bernhard Fasching, Débora Bonenfant, Amine Sadok et autres

Abstract The Myc family of transcription factors is a well-established driver of human cancers. However, despite being amongst the most frequently mutated, translocated and overexpressed oncogenes, no therapy directly targeting the Myc family members has been developed to date. Abnormal activation of …

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Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy

William McCoull, Scott Boyd, Martin R. Brown, Muireann Coen et autres

Inhibition of Mer and Axl kinases has been implicated as a potential way to improve the efficacy of current immuno-oncology therapeutics by restoring the innate immune response in the tumor microenvironment. Highly selective dual Mer/Axl kinase inhibitors are required to validate this …

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Developing an injectable co-formulation of two antidiabetic drugs: Excipient impact on peptide aggregation and pharmacokinetic properties

Anne-Laure Lainé, Sophie Houvenagel, Anders Broo, Ian David Jones et autres

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Enhanced oral delivery of celecoxib via the development of a supersaturable amorphous formulation utilising mesoporous silica and co-loaded HPMCAS

Anne-Laure Lainé, Daniel J. Price, Jessica L. Davis, D Roberts et autres

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Targeting and treatment of glioblastomas with human mesenchymal stem cells carrying ferrociphenol lipid nanocapsules

Anne Clavreul, Nolwenn Lautram, Florence Franconi, Catherine Passirani et autres

Recently developed drug delivery nanosystems, such as lipid nanocapsules (LNCs), hold great promise for the treatment of glioblastomas (GBs). In this study, we used a subpopulation of human mesenchymal stem cells, "marrow-isolated adult multilineage inducible" (MIAMI) cells, which have endogenous tumor-homing activity, …

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Conventional versus stealth lipid nanoparticles: Formulation and in vivo fate prediction through FRET monitoring

Anne-Laure Lainé, Julien Gravier, Maxime Henry, Lucie Sancey et autres

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Inhibition of ectopic glioma tumor growth by a potent ferrocenyl drug loaded into stealth lipid nanocapsules

Anne-Laure Lainé, Anne Clavreul, Audrey Rousseau, Clément Tétaud et autres

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Inhibition de la croissance tumorale d'un gliome ectopique par injections répétées de nanocapsules lipidiques chargées en ferrociphénol cyclique

Pauline Resnier, Anne-Laure Lainé, Anne Clavreul, Audrey Rousseau et autres

National audience

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The in vivo performance of ferrocenyl tamoxifen lipid nanocapsules in xenografted triple negative breast cancer

Anne-Laure Lainé, Éric Adriaenssens, Anne Vessières, Gérard Jaouen et autres

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Vectorisation de complexes ferrocéniques par les nanocapsules lipidiques pour le traitement du cancer

Anne-Laure Lainé

The aim of this work is the preclinical evaluation of three ferrocenyl complexes (FcOHTam, FcdiOH and ansa-FcdiOH) formulated into lipid nanocapsules (LNCs) for oncology purposes. Firstly, the anticancer activity of the ferrocifens is demonstrated on a triple negative breast cancer model with …

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Influence of the PEG coating on the delivery performance of stealth LNCs loaded with a ferrocenyl drug: application through ectopic glioma tumor treatment.

Anne-Laure Lainé, Anne Vessières, Gérard Jaouen, Jean‐Pierre Benoît et autres

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