Megan Wu

Abstract 3961: Identifying the molecular signature of infiltrating edge cells in glioblastoma as drivers of tumour invasion and recurrence

Alyona Ivanova, Shamini Ayyadhury, Yanxia Ma, Xuehong Gui et autres

Abstract Glioblastoma (GBM) is the most common malignant brain tumor in adults. Despite extensive research, there haven’t been remarkable gains in resolving the seeds of GBM recurrence, and the outcomes for many patients suffering from this devastating disease remain poor. Our knowledge …

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Abstract A038: Lomitapide enhances cytotoxic effects of temozolomide in chemo-resistant glioblastoma

Alyona Ivanova, Taylor M. Wilson, Kimia Ghannad‐Zadeh, Robert Flick et autres

Abstract Glioblastoma is the most prevalent and aggressive malignant primary brain tumour in adults, with a median survival following multi-modality therapy of 14.6 months. The current standard of care for patients with glioblastoma includes maximal safe surgical resection followed by radiation and …

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Lomitapide enhances cytotoxic effects of temozolomide in chemotherapy-resistant glioblastoma

Alyona Ivanova, Taylor M. Wilson, Kimia Ghannad‐Zadeh, Robert Flick et autres

More than a third of patients with glioblastoma experience tumor progression during adjuvant therapy. In this study, we performed a high-throughput drug repurposing screen of FDA-approved agents capable of crossing the blood-brain barrier in order to find agents to counteract acquired or …

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Regulation of Cancer Metastasis by PAK2

Megan Wu, Chandan Kumar Sarkar, Bin Guo

PAK2 is a serine-threonine kinase and a member of the p21-activated kinase (PAK) family. PAK2 is activated by GTP-bound rho family GTPases, Rac, and Cdc42, and it regulates actin dynamics, cell adhesion to the extracellular matrix, and cell motility. In various types …

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NVTG-03 IDENTIFYING THE DRIVERS OF EARLY BRAIN METASTASES ESTABLISHMENT IN BREAST CANCER PATIENTS

Alyona Ivanova, Matthew Cho, Megan Wu, David G. Muñoz et autres

Abstract Breast cancer is the most common type of cancer in women. It is also the 2nd most common cause of brain metastases (BrM), with 30-50% of breast cancer patients developing BrM over the course of their disease. Despite aggressive therapy and …

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Metabolic Lipids in Melanoma Enable Rapid Determination of Actionable BRAF-V600E Mutation with Picosecond Infrared Laser Mass Spectrometry in 10 s

Lauren Katz, Taira Kiyota, Michael Woolman, Megan Wu et autres

Rapid molecular profiling of biological tissues with picosecond infrared laser mass spectrometry (PIRL-MS) has enabled the detection of clinically important histologic types and molecular subtypes of human cancers in as little as 10 s of data collection and analysis time. Utilizing an …

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Data from Picosecond Infrared Laser Desorption Mass Spectrometry Identifies Medulloblastoma Subgroups on Intrasurgical Timescales

Michael Woolman, Claudia M. Kuzan-Fischer, Isabelle Ferry, Taira Kiyota et autres

Abstract Medulloblastoma (MB) is a pediatric malignant brain tumor composed of four different subgroups (WNT, SHH, Group 3, Group 4), each of which are a unique biological entity with distinct clinico-pathological, molecular, and prognostic characteristics. Although risk stratification of patients with MB …

Dual Laser and Desorption Electrospray Ionization Mass Spectrometry Imaging Using the Same Interface

Lauren Katz, Michael Woolman, Francis Talbot, Siham Amara-Belgadi et autres

For a more comprehensive characterization of molecular heterogeneities of matter, multimodal mass spectrometry imaging must be developed to take advantage of the complementarity of information available through different ionization mechanisms. We report the design, implementation, and performance validation of a laser desorption …

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In situ tissue pathology from spatially encoded mass spectrometry classifiers visualized in real time through augmented reality

Michael Woolman, Jimmy Qiu, Claudia M. Kuzan-Fischer, Isabelle Ferry et autres

tissue during tumor bed examination to assess cancer removal. The interface developed herein for the analysis and the display of spatially encoded PIRL-MS data can be adapted to other hand-held mass spectrometry analysis probes currently available.

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Picosecond Infrared Laser Desorption Mass Spectrometry Identifies Medulloblastoma Subgroups on Intrasurgical Timescales

Michael Woolman, Claudia M. Kuzan-Fischer, Isabelle Ferry, Taira Kiyota et autres

Abstract Medulloblastoma (MB) is a pediatric malignant brain tumor composed of four different subgroups (WNT, SHH, Group 3, Group 4), each of which are a unique biological entity with distinct clinico-pathological, molecular, and prognostic characteristics. Although risk stratification of patients with MB …

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Abstract 4118: Rapid, non-subjective characterization of disease in preclinical cancer research using desorption electrospray ionization mass spectrometry

Michael Woolman, Alessandra Tata, Isabelle Ferry, Claudia M. Kuzan-Fischer et autres

Abstract Cancer tissue smears are routinely used in rapid intraoperative pathology workflows using quick staining methods to characterize cancer in surgical margin assessments or tumor pathology. Mass spectrometry (MS) is a sensitive analytic platform that can detect the presence of cancer from …

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Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery

Saira Alli, Carlyn A. Figueiredo, Brian Golbourn, N. Sabha et autres

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