Rosario Luca Norrito

Artificial Intelligence and Multi-Omics Approaches in the Precision Management of Pulmonary Hypertension: From Early Diagnosis to Therapeutic Stratification

Sergio Ferrantelli, Alessandro Del Cuore, Giuliano Cassataro, Luigi Dell’Ajra et autres

Pulmonary hypertension (PH) is a heterogeneous clinical syndrome in which similar haemodynamic abnormalities may arise from distinct vascular, cardiac, pulmonary, thromboembolic, and molecular mechanisms. This complexity limits the ability of conventional classifications and risk scores to fully capture individual disease trajectories and …

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Artificial Intelligence and Multi-Omics Integration in the Precision Management of Pulmonary Hypertension: From Early Diagnosis to Therapeutic Stratification

Sergio Ferrantelli, Alessandro Del Cuore, Giuliano Cassataro, Luigi Dell’Ajra et autres

Pulmonary hypertension (PH) is a heterogeneous clinical syndrome in which similar haemodynamic abnormalities may arise from distinct vascular, cardiac, pulmonary, thromboembolic, and molecular mechanisms. This complexity limits the ability of conventional classifications and risk scores to fully capture individual disease trajectories and …

Molecular Mechanisms and Multi-Omics Integration in Heart Failure: From Pathophysiology to Precision Medicine

Carlo Domenico Maida, Gaetano Pacinella, Mario Daidone, Mariarita Margherita Bona et autres

Heart failure (HF) is a complex and heterogeneous clinical syndrome defined by progressive structural, functional, and molecular alterations in the myocardium, representing a significant global health challenge. Beyond haemodynamic compromise, HF arises from intricate interactions among neurohormonal activation, chronic inflammation, oxidative stress, …

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Dietary Modulation of Inflammatory and Oxidative Pathways in Type 2 Diabetes: Biomarkers and Cardiorenal Outcomes

Carlo Domenico Maida, Stefania Scaglione, Rosario Luca Norrito, Mario Daidone et autres

Type 2 diabetes mellitus is a relevant cardio-renal-metabolic disorder in which chronic low-grade inflammation and oxidative stress have a crucial function in linking insulin resistance, endothelial dysfunction, β-cell impairment, and progressive organ injury. In this context, nutrition has emerged as a key …

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Right Ventricular Function Across Different Respiratory Support Strategies in Severe Community-Acquired Pneumonia

Carlo Domenico Maida, Gaetano Pacinella, Mario Daidone, Rosario Luca Norrito et autres

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When Fever Strikes Twice: A Case Report of Streptococcus pneumoniae Myelitis with Delayed-Onset Reactive Arthritis

Rosario Luca Norrito, Sergio Mastrilli, Felice Fiorello, Giuseppe Taormina et autres

Abstract Background: Streptococcus pneumoniae is a well-known pathogen responsible for respiratory and invasive diseases; however, central nervous system (CNS) involvement in the form of bacterial myelitis is exceedingly rare, particularly in immunocompetent adults. Moreover, the association between pneumococcal infections and reactive arthritis …

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Urinary urodilatin levels in patients with renal salt wasting syndrome as a possible new diagnostic marker. A pilot study

Vittoriano Della Corte, Luisa Agnello, Rosario Luca Norrito, Marco Cataldi et autres

Background: Renal Salt Wasting Syndrome (RSW) is a clinical syndrome with laboratory characteristics completely overlapping with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). No studies have yet investigated the potential role of urodilatin as a diagnostic marker or its involvement in …

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Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes: Background and Therapeutic Approaches

Carlo Domenico Maida, Rosario Luca Norrito, Salvatore Rizzica, Marco Mazzola et autres

Stroke represents one of the neurological diseases most responsible for death and permanent disability in the world. Different factors, such as thrombus, emboli and atherosclerosis, take part in the intricate pathophysiology of stroke. Comprehending the molecular processes involved in this mechanism is …

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Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes: Background and Therapeutic Approaches

Carlo Domenico Maida, Rosario Luca Norrito, Salvatore Rizzica, Marco Mazzola et autres

Stroke represents one of the neurological diseases most responsible for death and permanent disability in the world. Different factors, such as thrombus, emboli and atherosclerosis, take part in the intricate pathophysiology of stroke. Comprehending the molecular processes involved in this mechanism is …

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Paraneoplastic Cerebellar Degeneration Associated with Breast Cancer: A Case Report and a Narrative Review

Rosario Luca Norrito, Maria Grazia Puleo, Chiara Pintus, Maria Grazia Basso et autres

Paraneoplastic neurological syndromes (PNSs) are an uncommon complication of cancer, affecting nearby 1/10,000 subjects with a tumour. PNSs can involve all the central and peripheral nervous systems, the muscular system, and the neuromuscular junction, causing extremely variable symptomatology. The diagnosis of the …

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Pathogenetic Mechanisms of Hypertension–Brain-Induced Complications: Focus on Molecular Mediators

Tiziana Di Chiara, Alessandro Del Cuore, Mario Daidone, Stefania Scaglione et autres

There is growing evidence that hypertension is the most important vascular risk factor for the development and progression of cardiovascular and cerebrovascular diseases. The brain is an early target of hypertension-induced organ damage and may manifest as stroke, subclinical cerebrovascular abnormalities and …

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Diabetes and Ischemic Stroke: An Old and New Relationship an Overview of the Close Interaction between These Diseases

Carlo Domenico Maida, Mario Daidone, Gaetano Pacinella, Rosario Luca Norrito et autres

Diabetes mellitus is a comprehensive expression to identify a condition of chronic hyperglycemia whose causes derive from different metabolic disorders characterized by altered insulin secretion or faulty insulin effect on its targets or often both mechanisms. Diabetes and atherosclerosis are, from the …

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