Anna Castañé

Cannabigerol improves MK-801-induced long-term recognition memory deficit in male rats through cortical TrkB-R signaling independently of changes in BDNF

Ximena López‐Hill, Soledad Marton, Analía Richeri, Sara Fabius et autres

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Photoactivated adenylyl cyclase in cortical astrocytes promotes synaptic potentiation and reveals alterations in Huntington’s disease

Laia Sitjà‐Roqueta, Neville Ngum, Evgenii Zherebstov, Melike Küçükerden et autres

Coordinated neuron-astrocyte interactions are crucial for synaptic plasticity and brain function. Cyclic adenosine monophosphate (cAMP) pathways have a key role in modulating plasticity and are disrupted in neurodegenerative diseases. Yet, the role of astrocytic cAMP remains unclear. We addressed this by expressing …

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Differential impact of optogenetic stimulation of direct and indirect pathways from dorsolateral and dorsomedial striatum on motor symptoms in Huntington's disease mice

Sara Conde-Berriozabal, Laia Sitjà‐Roqueta, Esther García-García, Lia García-Gilabert et autres

The alterations in the basal ganglia circuitry are core pathological hallmark in Huntington's Disease (HD) and traditionally linked to its sever motor symptoms. Recently it was shown that optogenetic stimulation of cortical afferences to the striatum is able to reverse motor symptoms …

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A combination of Δ9-tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer's disease

Núria Sánchez-Fernández, Laura Gómez-Acero, Anna Castañé, Albert Adell et autres

A combination of Δ 9 -tetrahydrocannabinol (Δ 9 -THC) and cannabidiol (CBD) at non-psychoactive doses was previously demonstrated to reduce cognitive decline in APP/PS1 mice, an animal model of Alzheimer's disease (AD). However, the neurobiological substrates underlying these therapeutic properties of Δ …

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Differential contribution of direct and indirect pathways from dorsolateral and dorsomedial striatum to motor symptoms in Huntington’s disease mice

Sara Conde-Berriozabal, Laia Sitjà‐Roqueta, Esther García-García, Lia García-Gilabert et autres

ABSTRACT The alterations in the basal ganglia circuitry associated with motor symptoms in Huntington’s Disease (HD) have been extensively investigated. Yet, the specific contribution of the direct and indirect striatal output pathways from the dorsolateral (DLS) and dorsomedial striatum (DMS) to the …

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A combination of Δ9-tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer’s disease

Núria Sánchez-Fernández, Laura Gómez-Acero, Anna Castañé, Albert Adell et autres

Abstract Background: Dysregulation of glutamatergic activity has been shown to contribute to cognitive impairment and to the progression of the neurodegenerative process in Alzheimer’s disease (AD). Previous data revealed that chronic treatment with a combination of two natural cannabinoids, Δ9-tetrahydrocannabinol (THC) and …

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PHYTOCHROME STIMULATION IN ASTROCYTES: MOTOR PHENOTYPE EFFECTS ON HUNTINGTON’S DISEASE

Laia Sitjà Roqueta, Neville Ngum, Melike Küçükerden, Sara Conde Berriozabal et autres

Huntington’s disease (HD) is an hereditary neurodegenerative disorder caused by a CAG repeat expansion within the huntingtin gene and characterized by motor disturbances. Phytochrome photoreceptors can control adenylate cyclases to produce cAMP in cells upon photoactivation, allowing spatio-temporal modulation of cAMP, which …

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Discrimination of motor and sensorimotor effects of phencyclidine and MK-801: Involvement of GluN2C-containing NMDA receptors in psychosis-like models

Mireia Tarrés-Gatius, Ximena López‐Hill, Lluís Miquel-Rio, Laura Castarlenas et autres

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Dual 5-HT3 and 5-HT6 Receptor Antagonist FPPQ Normalizes Phencyclidine-Induced Disruption of Brain Oscillatory Activity in Rats

Anna Castañé, Montserrat Cano, Luis Ruíz-Ávila, Lluís Miquel-Rio et autres

Schizophrenia is a severe mental disorder featuring psychotic, depressive, and cognitive alterations. Current antipsychotic drugs preferentially target dopamine D2-R and/or serotonergic 5-HT2A/1A-R. They partly alleviate psychotic symptoms but fail to treat negative symptoms and cognitive deficits. Here we report on the putative …

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Involvement of NMDA receptors containing the GluN2C subunit in the psychotomimetic and antidepressant-like effects of ketamine

Mireia Tarrés-Gatius, Lluís Miquel-Rio, Leticia Campa, Francesc Artigas et autres

Acute ketamine administration evokes rapid and sustained antidepressant effects in treatment-resistant patients. However, ketamine also produces transient perceptual disturbances similarly to those evoked by other non-competitive NMDA-R antagonists like phencyclidine (PCP). Although the brain networks involved in both ketamine actions are not …

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Serotonin receptors: Implications for depression and its treatment

Anna Castañé, Francesc Artigas

Trabajo presentado en el 14th World Congress of Biological Psychiatry, celebrado en Vancouver (Canada), del 2 al 6 de junio de 2019

Astrocyte control of glutamatergic activity: Downstream effects on serotonergic function and emotional behavior

Neus Fullana, Júlia Gasull-Camós, Mireia Tarrés-Gatius, Anna Castañé et autres

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