Caitlin Guccione

Abstract 1097: Performance of a blood-based screening test for the early detection of advanced precancerous lesions

Prashanthi Natarajan, Preethi Srinivasan, Hsiao‐Yun Huang, Alan Selewa et autres

Abstract Current colorectal cancer (CRC) screening methodologies, such as colonoscopy and stool-based tests, have shown substantial efficacy but are often constrained by low patient compliance. A minimally-invasive blood-based test can enhance screening adherence. Previous studies evaluating the performance of our blood-based CRC …

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Community assembly modeling of the microbiome within Barrett’s esophagus and esophageal adenocarcinoma

Caitlin Guccione, Igor Sfiligoi, ANTONIO SERRANO GONZÁLEZ, Justin P. Shaffer et autres

Computational modeling of somatic evolution, a process shaped by ecology and impacting both host cells and microbial communities in the human body, can capture important dynamics driving carcinogenesis. Here we considered models for esophageal adenocarcinoma (EAC), a cancer that has dramatically increased …

us, hk (code pays fourni par la source)

Community assembly modeling of the microbiome within Barrett’s esophagus and esophageal adenocarcinoma

Caitlin Guccione, Igor Sfiligoi, Antonio Gonzalez, Justin P. Shaffer et autres

Abstract Computational modeling of somatic evolution, a process shaped by ecology and impacting both host cells and microbial communities in the human body, can capture important dynamics driving carcinogenesis. Here we considered models for esophageal adenocarcinoma (EAC), a cancer that has dramatically …

us, hk (code pays fourni par la source)

Community assembly modeling of the microbiome within Barrett’s esophagus and esophageal adenocarcinoma

Caitlin Guccione, Igor Sfiligoi, Antonio Gonzalez, Justin P. Shaffer et autres

Abstract Computational modeling of somatic evolution, a process shaped by ecology and impacting both host cells and microbial communities in the human body, can capture important dynamics driving carcinogenesis. Here we considered models for esophageal adenocarcinoma (EAC), a cancer that has dramatically …

us, hk (code pays fourni par la source)

Additional file 1 of Community assembly modeling of the microbiome within Barrett’s esophagus and esophageal adenocarcinoma

Caitlin Guccione, Igor Sfiligoi, Antonio Gonzalez, Justin P. Shaffer et autres

Supplementary Material 1.

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Additional file 1 of Community assembly modeling of the microbiome within Barrett’s esophagus and esophageal adenocarcinoma

Caitlin Guccione, Igor Sfiligoi, Antonio Gonzalez, Justin P. Shaffer et autres

Supplementary Material 1.

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Quantification of circulating tumor DNA (ctDNA) using a methylation-based, tissue-free colorectal cancer (CRC) test for the detection of molecular residual disease (MRD).

Yoshiaki Nakamura, Princy Parsana, Tzu-Chun Chen, Nathan L. Liang et autres

217 Background: MRD detection by measuring ctDNA has been shown to predict disease recurrence. We have previously demonstrated that a tissue-free ctDNA test (Latitude, Natera, Inc.) for MRD detection in CRC patients is prognostic and predictive of outcomes in both the post-operative …

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Calculating fast differential genome coverages among metagenomic sources using micov

Yuhan Weng, Caitlin Guccione, Daniel McDonald, Renee Oles et autres

Breadth of coverage, the proportion of a reference genome covered by at least one sequencing read, is critical for interpreting metagenomic data, informing analyses from genome assembly to taxonomic profiling. However, existing tools typically summarize coverage breadth at the whole-genome or aggregate-sample …

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Blood microbial DNA signature differentiates hepatocellular carcinoma from metastatic lesions

Caitlin Guccione, Ana Carolina Dantas Machado, Fady Youssef, Isabella Angeli‐Pahim et autres

The microbiome influences cancer development, progression, and therapy response 46 across various malignancies [1, 2, 3, 4, 5].The composition and diversity of microbial 47 communities within various tissues, influence cancer development, progression, and therapy 48 response.Understanding specific microbial signatures associated with cancers, …

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Mo2012: UNIQUE BLOOD MICROBIAL DNA SIGNATURES IDENTIFY HEPATOCELLULAR CARCINOMA AS DISTINCT FROM METASTATIC LIVER TUMORS

Caitlin Guccione, Ana Carolina Dantas Machado, Fady Youssef, Isabella Angeli‐Pahim et autres

Abstract 3692: Computational modeling of human microbiome evolution in the context of esophageal adenocarcinoma progression

Caitlin Guccione, I. Sfiligoi, Antonio González, Justin P. Shaffer et autres

Abstract Elucidating the role of microbes in precancer evolution could transform clinical risk prediction and management strategies. In the case of esophageal adenocarcinoma (EAC) progression, microbial communities have been detected across precancerous and neoplastic stages. However, unlike prior studies that statistically compare …

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Abstract 6244: Comparative diversity analysis of microbial composition across tissue and fecal samples in multi-cohort, multi-study cancer analyses

Tiffany Zhang, K. M. Chan, Caitlin Guccione, Bertalan Takács et autres

Abstract The microbial ecosystems in tumors, surrounding tissues, and the gut (which influences processes throughout the body) offer new opportunities for oncology diagnostics and treatment, but inconsistencies in metadata quality and parameters across abundant public data hinder generalizable conclusions. To address these …

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