Britta George

The potential role of antimetabolite in preventing allosensitization before kidney retransplantation

Madeleine Thommen, Lukas Weidmann, Dušan Harmáček, Seraina von Moos et autres

Background and aims Retransplantation is becoming more common. Allosensitization represents an increasing issue, as it prolongs the time on the waiting list and worsens the outcome of a second transplant. The optimal maintenance immunosuppression (IS) after graft failure remains unclear. Methods This …

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Molecular rejection signals in chronic-active T cell–mediated rejection: Histological associations and potential clinical implications

Lukas Weidmann, Petra Hrubá, Eva Girmanová, Dušan Harmáček et autres

WCN26-6943 “ISOLATED V-LESIONS” DO NOT SHOW MOLECULAR REJECTION, BUT IN COMBINATION WITH MICROVASCULAR INFLAMMATION, INCREASE THE PROBABILITY OF MOLECULAR MIXED REJECTION

Evelyn Kowarik, Lukas Weidmann, Dušan Harmáček, Kai Castrezana-Lopez et autres

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Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation

Kai Castrezana Lopez, Lukas Weidmann, Dušan Harmáček, Fabian Rössler et autres

Background and hypothesis: In ABO-incompatible (ABOi) kidney transplantation, C4d deposition is associated with accommodation rather than rejection. Isoagglutinins targeting blood group antigens A/B are also classified as donor-specific antibodies (DSA). Therefore, the diagnosis of antibody-mediated rejection (AMR) relies primarily on microvascular inflammation …

Molecular rejection signals in chronic-active T cell–mediated rejection: Histological associations and potential clinical implications

Lukas Weidmann, Petra Hruba, Eva Girmanová, Dušan Harmáček et autres

Chronic-active T cell–mediated rejection (caTCMR) remains debated, and molecular diagnostics might aid risk-stratification. This retrospective two-center observational study analyzed 26 kidney allograft biopsies with caTCMR, comparing them to 40 borderline T cell–mediated rejection (bTCMR)/acute T cell–mediated rejection (aTCMR) cases (without caTCMR) and …

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Inseparable in Disease, Yet Treated Apart: A Retrospective Study of a Cardiorenal Cohort at a Tertiary University Hospital

Christian Martinetti, Britta George, Thomas Schachtner, Frank Ruschitzka et autres

Introduction: The prevalence of cardiorenal syndrome (CRS) and its management might be challenging, so an interdisciplinary approach is advocated. The aim of this study was to identify and describe the population which might profit from such an interdisciplinary clinic at the University …

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Non-human leukocyte antigen autoantibodies—anti-angiotensin II type 1 receptor and endothelin type A receptor antibodies—in the diagnosis of antibody-mediated rejection: Biopsy-based transcript diagnostics perspective

Dušan Harmáček, Lukas Weidmann, Elena Rho, Kai Castrezana Lopez et autres

Antibody-mediated rejection in ABO-incompatible kidney transplantation

Kai Castrezana Lopez, Lukas Weidmann, Dušan Harmáček, Fabian Rössler et autres

BACKGROUND AND HYPOTHESIS: In ABO-incompatible (ABOi) kidney transplantation, C4d deposition is associated with accommodation rather than rejection. Isoagglutinins targeting blood group antigens A/B are also classified as donor-specific antibodies (DSA). Therefore, the diagnosis of antibody-mediated rejection (AMR) relies primarily on microvascular inflammation …

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Pathomechanisms of Antinephrin Antibody–Mediated Podocytopathy

Carolin Eul, Britta George

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Pathomechanisms of Antinephrin Antibody–Mediated Podocytopathy

Carolin Eul, Britta George

#3429 Biopsy-based transcriptomics allow earlier detection of rejection, gradual phenotyping and monitoring of anti-rejection treatment interventions in kidney transplant recipients: lessons from follow-up biopsies

Lukas Weidmann, Florian Westphal, Dušan Harmáček, Elena Rho et autres

Abstract Background and Aims Transcriptomics in biopsy-based diagnosis of kidney allograft rejection has the potential to detect rejection earlier than histopathology, offer continuous rejection phenotyping, and quantify disease activity and injury degrees to reflect anti-rejection treatment responses. Method From 2018 to 2024, …

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#3202 Biopsy-based transcript diagnostics improves prognostication along the AMR continuum

Elena Rho, Lukas Weidmann, Kai Castrezana Lopez, Dušan Harmáček et autres

Abstract Background and Aims Clinical utility of biopsy-based transcript diagnostics with respect to risk stratification and prognostication for graft outcome used in addition to histology along the AMR continuum of Banff 2022 has not been investigated. Method We examined 297 kidney allograft …

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