Monika Juzumaite

Lifetime sexual violence exposure in women compromises systemic innate immune mediators associated with HIV pathogenesis: A cross-sectional analysis

Jason Daniels, Annette Aldous, Maria Pyra, Yu Xia et autres

OBJECTIVES: Violence and HIV/AIDS syndemic highly prevalent among women impairs HIV prevention efforts. Prolonged exposure to violence results in physical trauma and psychological distress. Building on previous findings regarding genital immune dysregulation following sexual abuse exposure, we investigate here whether systemic changes …

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Recent sexual violence exposure is associated with immune biomarkers of HIV susceptibility in women

Annette Aldous, Christopher Joy, Jason Daniels, Mariel Jais et autres

PROBLEM: HIV/AIDS and sexual violence act synergistically and compromise women's health. Yet, immuno-biological mechanisms linking sexual violence and increased HIV susceptibility are poorly understood. METHODS: We conducted a cross-sectional pilot study of HIV-uninfected women, comparing 13 women exposed to forced vaginal penetration …

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Immune biomarkers and anti‐ HIV activity in the reproductive tract of sexually active and sexually inactive adolescent girls

Mimi Ghosh, Mariel Jais, Roshni Biswas, Jason Jarin et autres

PROBLEM: Adolescent girls are disproportionately affected by the HIV/AIDS pandemic, accounting for 22% of all new HIV infections globally. Yet little is known regarding the immune microenvironment of the adolescent female reproductive tract, especially regarding differences among sexually active and inactive girls, …

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Impact of chronic sexual abuse and depression on inflammation and wound healing in the female reproductive tract of HIV-uninfected and HIV-infected women.

Mimi Ghosh, Jason Daniels, Maria Pyra, Monika Juzumaite et autres

Sexual violence is associated with increased risk of HIV acquisition/transmission in women. Forced sex can result in physical trauma to the reproductive tract as well as severe psychological distress. However, immuno-biological mechanisms linking sexual violence and HIV susceptibility are incompletely understood. Using …

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性的に活動的および性的に不活性な思春期女子の生殖管における免疫バイオマーカーおよび抗HIV活性【JST・京大機械翻訳】

Ghosh Mimi, Jais Mariel, Biswas Roshni, J. Xuan Jason et autres

Impact of Chronic Sexual Abuse and HIV on Genital Tract Biomarker Expression in Women

Jason Daniels, Maria Pyra, Monika Juzumaite, Mariel Jais et autres

Secondary Metabolites from Fungal Endophytes of Echinacea purpurea Suppress Cytokine Secretion by Macrophage-Type Cells

Amninder Kaur, Martina Oberhofer, Monika Juzumaite, Huzefa A. Raja et autres

Botanical extracts of Echinacea purpurea have been widely used for the treatment of upper respiratory infections. We sought to chemically examine fungal endophytes inhabiting E. purpurea, and to identify compounds produced by these endophytes with in vitro cytokine-suppressive activity. Twelve isolates from …

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Cytokine-Suppressive Activity of a Hydroxylated Alkylamide from Echinacea purpurea

Martha Leyte‐Lugo, Daniel A. Todd, Travis V. Gulledge, Monika Juzumaite et autres

Echinacea purpurea has been widely used to treat upper respiratory tract infections. Bioassay-guided fractionation of hexane and ethanol extracts of this plant yielded 4[(2-methylbutyl)amino]-4-oxo-2-butenoic acid ( 1 ) and 8,11-dihidroxy-dodeca-2 E ,4 E ,9 E -trienoic acid isobutylamide ( 2 ), both …

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Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria

Daniel A. Todd, Travis V. Gulledge, Emily R. Britton, Martina Oberhofer et autres

Echinacea preparations, which are used for the prevention and treatment of upper respiratory infections, account for 10% of the dietary supplement market in the U.S., with sales totaling more than $100 million annually. In an attempt to shed light on Echinacea's mechanism …

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Chemical investigation of fungal endophytes from Echinacea purpurea

Diana Kao, Amninder Kaur, H. David Raja, Tamam El‐Elimat et autres

Botanical extracts of Echinacea purpurea have been traditionally used for treatment of respiratory infections. Recently, efforts to chemically examine the fungal endophytes inhabiting these plants were undertaken to investigate the role of endophyte colonization on the bioactivity of such medicinal herbs. In …

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Healthy Teen Scholars

Haneen Abudayyeh, Kristen Aquino, Kristely Bastien, Katie Baumann et autres

Welcome to the Healthy Teen Scholars learning community! Our group is comprised of a diverse group of graduate students from different backgrounds with different health interests! We work with DC youth at both Dunbar and Anacostia High Schools. Our community partners are …