Catherine A. Hilliard

Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing

Derun Li, David L. Sloman, Abdelghani Achab, Hua Zhou et autres

3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable for Q3W (once every 3 weeks) oral and parenteral dosing. A diamide class of IDO …

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Synthesis and Evaluation ofS-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication

Thazha P. Prakash, Marija Prhavc, Anne B. Eldrup, P. Dan Cook et autres

Several triphosphates of modified nucleosides (1-6) were identified as inhibitors (IC(50) = 0.08-3.8 microM) of hepatitis C virus RNA-dependent RNA polymerase (RdRp). Although the initial SAR developed by determining the ability of the triphosphates to inhibit the in vitro activity of the …

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Getting it all together: German art libraries in the year 2000

Catherine A. Hilliard

Electronic retrieval of information is only one of the many aspects of librarianship seen by delegates on the recent ARLIS/UK & Ireland study tour of art libraries in Germany. Diverse in their history and development, these are today being drawn together into …

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Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster

Chang Bai, Brett Connolly, Michael L. Metzker, Catherine A. Hilliard et autres

Fas-mediated apoptosis is an important regulator of cell survival, and abnormalities in this system have been shown to result in a number of human pathological conditions. A secreted member of the tumor necrosis factor receptor superfamily, DcR3, was recently reported to be …

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Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53

Susan K. Greenwood, Michael J. Armstrong, Rosina Hill, Carole I. Bradt et autres

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Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals and metabolic poisons

Catherine A. Hilliard, Michael J. Armstrong, Carole I. Bradt, Rosina Hill et autres

Chromosome aberrations can occur by secondary mechanism(s) associated with cytotoxicity, induced by chemicals that do not attack DNA. Aberrations are formed from DNA double-strand breaks, and DSBs are known to be induced by nonmutagenic (Ames test negative) noncarcinogens at toxic levels [Storer …

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Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals and metabolic poisons

Catherine A. Hilliard, Michael J. Armstrong, Carole I. Bradt, Rosina Hill et autres

Regional Localization of over 300 Loci on Human Chromosome 22 Using a Somatic Cell Hybrid Mapping Panel

Marcia L. Budarf, Barbara A. Eckman, Dominique Michaud, Terrence P. McDonald et autres

A somatic cell hybrid panel, consisting of 25 cell lines, has been developed to localize loci subregionally on chromosome 22. Over 300 markers in the form of STSs or hybridization probes have been assigned to one of 24 unique regions or "bins" …

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FISH analysis of a patient with a constitutional 1p36 deletion defines a region for a neuroblastoma tumor suppressor gene

Jaclyn A. Biegel, Catherine A. Hilliard, Peter S. White

Molecular and cytogenetic studies of neuroblastoma have implicated the presence of one or more tumor suppressor genes on chromosome 1p. We previously reported a neuroblastoma patient with a constitutional interstitial deletion of 1p36. As one means of further defining the deleted region, …

Hensley C. Woodbridge and David S. Zubatsky, "Pablo Neruda. An Annotated Bibliography of Bibliographical and Critical Studies" (Book Review)

Catherine A. Hilliard, Chris Perriam