Cecilia Johansson

Type I interferons induced upon respiratory viral infection impair lung metastatic initiation

Ana Farias, Victoria L. Bridgeman, Felipe Silva Rodrigues, Rute M. M. Ferreira et autres

Abstract Invasive breast cancer accounts for 7% of all cancer-related deaths, with the lungs being a common site of metastases. At the same time, lower respiratory tract infections are a common cause of morbidity and mortality worldwide. Acute viral respiratory infections induce …

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Natural Killer Cells Are Dispensable for Virus Control in Rag2 −/− Mice During Primary RSV Infection

Joy Nakawesi, Tammie Sow Tao Min, Cecilia Johansson

ABSTRACT Respiratory syncytial virus (RSV) is one of the major causes of severe lower respiratory tract infections, especially in children, the elderly, and immunocompromised individuals. Complications arising from viral infections in these age groups can present therapeutic challenges, as most of these …

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Sustained Lung Inflammation Post‐SARS‐CoV‐2 Infection in Mice Is Associated with Increased Pulmonary T Cells

Patricia P. Ogger, Ana Farias, Minerva Garcia Martín, Joy Nakawesi et autres

ABSTRACT Many SARS‐CoV‐2 patients experience chronic pulmonary symptoms and long‐term inflammation despite viral clearance. While these clinical manifestations have been linked to the dysregulation of the adaptive immune response, the underlying immunopathology remains poorly understood due to a lack of suitable animal …

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RORing for oral tolerance

Cecilia Johansson

An antigen-presenting cell subtype tames the immune response to food antigens in early life.

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Ageing results in an exacerbated inflammatory response to LPS by resident lung cells

Celia Diaz-Nicieza, Laura Sahyoun, Christina Michalaki, Cecilia Johansson et autres

BACKGROUND: Ageing is associated with an increased risk of lung infection and chronic inflammatory lung disease. Innate immune responses are the first line of defence in the respiratory tract, however, age-related changes to innate immunity in the lung are not fully described. …

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Exposure to bacterial PAMPs before RSV infection exacerbates innate inflammation and disease via IL-1α and TNF-α

Amber Owen, Ana Farias, Anne-Marie Levins, Ziyin Wang et autres

Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infections. Understanding why some individuals get more serious disease may help with diagnosis and treatment. One possible risk factor underlying severe disease is bacterial exposure before RSV infection. Bacterial exposure has been …

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SARS-CoV-2 strains bearing Omicron BA.1 spike replicate in C57BL/6 mice

Patricia P. Ogger, Minerva Garcia Martín, Soyeon Jang, Jie Zhou et autres

Introduction SARS-CoV-2, the cause of the COVID pandemic, is an RNA virus with a high propensity to mutate. Successive virus variants, including variants of concern (VOC), have emerged with increased transmission or immune escape. The original pandemic virus and early variants replicated …

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PREDICTING IMPACT SOUND INSULATION OF THE WOODEN JOIST FLOORS - AN APPLICATION OF EUROPEAN MODELS

Wanqing Shi, Cecilia Johansson, Ulrik Sundbäck

Predicting impact sound insulation of wooden joist floors : an application of European models

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EXPERIMENTAL DETERMINATION OF REVERBERATION TIME FOR LOW FREQUENCIES IN AN IMPACT SOUND LABORATORY

Cecilia Johansson, Wanqing Shi

Experimental determination of reverberation time for low frequencies in an impact sound laboratory

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TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity

William D. Jackson, Chiara Giacomassi, Sophia Ward, Amber Owen et autres

Monocytes are heterogeneous innate effector leukocytes generated in the bone marrow and released into circulation in a CCR2-dependent manner. During infection or inflammation, myelopoiesis is modulated to rapidly meet the demand for more effector cells. Danger signals from peripheral tissues can influence …

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Author response: TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity

William D. Jackson, Chiara Giacomassi, Sophia Ward, Amber Owen et autres

A novel pathway of emergency myelopoiesis is induced by repetitive virus stimulation at peripheral barrier sites which bypasses the requirement of conventional pathways and expands myeloid infiltration in tissues.

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Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day et autres

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