Daniel Musikant

Chitosan nanogels for the improvement of benznidazole activity

Daniel Musikant, Luna Magrotti-Messa, Matías Schafrik, Luciana Pelazzo et autres

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Host cell cAMP-Epac-Rap1b pathway inhibition by hawthorn extract as a potential target against Trypanosoma cruzi infection

Gabriel Ferri, Lucía R. Fernández, Guillermo Di Mario, Daniel Musikant et autres

Although the two drugs currently available for the treatment of Chagas disease, Benznidazole and Nifurtimox, have proven to be effective in the acute phase of the disease, the 60–90-day treatment leads to high toxicity and unwanted side effects, presenting, in addition, a …

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Host Cell Rap1b mediates cAMP-dependent invasion by Trypanosoma cruzi

Gabriel Ferri, Daniel Musikant, Martín M. Edreira

Trypanosoma cruzi cAMP-mediated invasion has long been described, however, the detailed mechanism of action of the pathway activated by this cyclic nucleotide still remains unknown. We have recently demonstrated a crucial role for Epac in the cAMP-mediated invasion of the host cell. …

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Lipase-Catalyzed Synthesis and Biological Evaluation of N-Picolineamides as Trypanosoma cruzi Antiproliferative Agents

Daniel Musikant, José L. Escalona, Martín M. Edreira, Guadalupe García Liñares

In our search for new safe antiparasitic agents, an enzymatic pathway was applied to synthesize a series of N -pyridinylmethyl amides derived from structurally different carboxylic acids. Thirty derivatives, including 11 new compounds, were prepared through lipase-catalyzed acylation in excellent yields. In …

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Carbohydrate-Derived Polytriazole Nanoparticles Enhance the Anti-Inflammatory Activity of Cilostazol

M. Verónica Rivas, Daniel Musikant, Rocío Diaz Peña, Daniela S. Álvarez et autres

Poly(amide-triazole) and poly(ester-triazole) synthesized from d-galactose as a renewable resource were applied for the synthesis of nanoparticles (NPs) by the emulsification/solvent evaporation method. The NPs were characterized as stable, spherical particles, and none of their components, including the stabilizer poly(vinyl alcohol), were …

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Sialic acid removal by trans-sialidase modulates MMP-2 activity during Trypanosoma cruzi infection

Daniel Musikant, Romina Higa, Cristina E. Rodríguez, Martín M. Edreira et autres

Matrix metalloproteinases (MMPs) not only play a relevant role in homeostatic processes but are also involved in several pathological mechanisms associated with infectious diseases. As their clinical relevance in Chagas disease has recently been highlighted, we studied the modulation of circulating MMPs …

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Naturally Occurring Alkaloids, Derivatives, and Semi-synthetic Modifications as Lead Compounds for the Development of New Anti-Trypanosoma cruzi Agents

Lucía R. Fernández, Daniel Musikant, Martín M. Edreira

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Hybrids of Cinchona Alkaloids and Bile Acids as Antiparasitic Agents Against Trypanosoma cruzi

Daniel Musikant, Aurélie Leverrier, Gabriel Ferri, Jorge A. Palermo et autres

The current chemotherapy of Chagas disease needs to be urgently improved. With this aim, a series of 16 hybrids of Cinchona alkaloids and bile acids were prepared by functionalization at position C-2 of the quinoline nucleus by a radical attack of a …

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Maternal diabetes induces FoxO1 and connexin 43 alterations in the heart of the developing embryo

Hugo Sato, Sabrina Lorena Roberti, Daniel Musikant, Alicia Jawerbaum et autres

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Altered FOXO1 activation in the programming of cardiovascular alterations by maternal diabetes

Daniel Musikant, Hugo Sato, Evangelina Capobianco, Verónica White et autres

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Host Epac1 is required for cAMP-mediated invasion by Trypanosoma cruzi

Daniel Musikant, Gabriel Ferri, Ignacio M. Durante, Carlos A. Buscaglia et autres

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Trypanosoma cruzi trans -Sialidase Prevents Elicitation of Th1 Cell Response via Interleukin 10 and Downregulates Th1 Effector Cells

Pablo Díaz, Juan Mucci, Maria Meira, Y. S. Bogliotti et autres

The trans-sialidases (TSs) from Trypanosoma cruzi, the agent of Chagas disease, are virulence factors shed to the bloodstream that induce strong alterations in the immune system. Here, we report that both enzymatically active TS (aTS) and its lectinlike isoform (iTS) disturb CD4 …

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