Emmanuel Thomas

Editorial Expression of Concern: A FADD-dependent innate immune mechanism in mammalian cells

Siddharth Balachandran, Emmanuel Thomas, Glen N. Barber

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Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models

Deepa Seetharam, Jay S. Chandar, Christian Kieran Ramsoomair, Jelisah Desgraves et autres

Viral mimicry refers to the activation of innate antiviral immune responses due to the induction of endogenous retroelements (REs). Viral mimicry augments antitumor immune responses and sensitizes solid tumors to immunotherapy. Here, we found that targeting what we believe to be a …

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Current and Future Diagnostics for Hepatitis C Virus Infection

Hussein Zilouchian, Omair Faqah, Md Alamgir Kabir, Dennis C. Gross et autres

Hepatitis C virus (HCV), a member of the Flaviviridae family, is an RNA virus enclosed in an envelope that infects approximately 50 million people worldwide. Despite its significant burden on public health, no vaccine is currently available, and many individuals remain unaware …

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Targeting ZNF638 activates antiviral immune responses and potentiates immune checkpoint inhibition in glioblastoma

Deepa Seetharam, Jay S. Chandar, Christian Kieran Ramsoomair, Jelisah Desgraves et autres

Abstract Viral mimicry refers to the activation of innate anti-viral immune responses due to the induction of endogenous retroelement (RE) expression. Viral mimicry has been previously described to augment anti-tumor immune responses and sensitize solid tumors to immunotherapy including colorectal cancer, melanoma, …

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259 Eighty-six-fold increase in HIV diagnosis with “Opt-out” Screening: Frontlines of Communities in the U.S. (FOCUS) Program in the UHealth Tower (UHT) Emergency Department (ED) - path to eliminate HIV transmission in the U.S.

Dushyantha T. Jayaweera, Yaa Fosuah Abu, Barbara Huang, Emmanuel Thomas et autres

OBJECTIVES/GOALS: Early HIV detection and treatment are key to reducing patient morbidity and mortality, yet 40% of people living with HIV do not know their status. “OPT-OUT” approaches to hiv testing, in which patients #_MSOCOM_1 are informed that an HIV test will …

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O- 23 STRATEGIES TO ELIMINATE HEPATITIS C VIRUS INFECTION IN THE AMERICAS

Luis Antonio Díaz, Sérgio Britto Garcia, Rayan Khan, Gustavo Ayares et autres

Although the WHO strategy aims to eliminate the hepatitis C virus (HCV) as a public health threat by 2030, national strategies are variable worldwide. This study aimed to assess the establishment of different policies and strategies to eliminate HCV in the Americas. …

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Experimentally Induced Reductions in Alcohol Consumption and Brain, Cognitive, and Clinical Outcomes in Older Persons With and Those Without HIV Infection (30-Day Challenge Study): Protocol for a Nonrandomized Clinical Trial

Robert L. Cook, Veronica L. Richards, Joseph M. Gullett, Brenda Lerner et autres

BACKGROUND: Both alcohol consumption and HIV infection are associated with worse brain, cognitive, and clinical outcomes in older adults. However, the extent to which brain and cognitive dysfunction is reversible with reduction or cessation of drinking is unknown. OBJECTIVE: The 30-Day Challenge …

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Experimentally Induced Reductions in Alcohol Consumption and Brain, Cognitive, and Clinical Outcomes in Older Persons With and Those Without HIV Infection (30-Day Challenge Study): Protocol for a Nonrandomized Clinical Trial (Preprint)

Robert L. Cook, Veronica L. Richards, Joseph M. Gullett, Brenda Lerner et autres

BACKGROUND Both alcohol consumption and HIV infection are associated with worse brain, cognitive, and clinical outcomes in older adults. However, the extent to which brain and cognitive dysfunction is reversible with reduction or cessation of drinking is unknown. OBJECTIVE The 30-Day Challenge …

Shorter Duration Hepatitis C Virus Treatment is Associated with Better Persistence to Prescription Refills in People Who Inject Drugs: A Real-World Study

Anthony D. Martinez, Wei‐Han Cheng, Steven E. Marx, Shivaji R. Manthena et autres

INTRODUCTION: Direct-acting antiviral (DAA) therapy is highly effective in curing hepatitis C virus (HCV) infection in people who inject drugs (PWID). Previous studies showed declining persistence to DAA therapy over the course of treatment. This study compares real-world medication persistence to prescription …

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One in-clinic dose of gentamicin, posaconazole and mometasone furoate ear drops suspension is a safe and effective treatment for canine otitis externa

Lea Heuer, Eva Zschiesche, Emmanuel Thomas

Clinical abstract presented at BSAVA Congress 2023. See full text for abstract and see clinical abstract sessions for a recording of the presentation. Abstracts are presented as supplied and have not been edited.

Combined Use of RT-qPCR and NGS for Identification and Surveillance of SARS-CoV-2 Variants of Concern in Residual Clinical Laboratory Samples in Miami-Dade County, Florida

Yamina Carattini, Anthony J. Griswold, Siôn Ll. Williams⁎, Ranjini Valiathan et autres

Over the course of the COVID-19 pandemic, SARS-CoV-2 variants of concern (VOCs) with increased transmissibility and immune escape capabilities, such as Delta and Omicron, have triggered waves of new COVID-19 infections worldwide, and Omicron subvariants continue to represent a global health concern. …

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Acrylic-based culture plate format perfusion device to establish liver endothelial–epithelial interface

Dennis McDuffie, Charles G. Alver, Bhumi Suthar, Madeline Helm et autres

. We used a liver model with a hepatic progenitor cell line and human umbilical vein endothelial cells to assess the biological efficacy of the MPS. We computationally modeled the physics that govern the function of perfusion through the MPS. Empirically, efficacy …

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