Oluremi N Ajala

Effect of Vitamin D 3 Supplements on Development of Advanced Cancer

Paulette D. Chandler, Wendy Y. Chen, Oluremi N Ajala, Aditi Hazra et autres

Importance: Epidemiologic and trial data suggest that vitamin D supplementation may reduce metastatic cancer and cancer mortality, reflecting shared biological pathways. Objective: To follow up on the possible reduction in cancer death in the Vitamin D and Omega-3 Trial (VITAL) with an …

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Abstract 16471: Lipoprotein(a) Cholesterol and Cardiovascular Events in the VITamin D and OmegA 3 TriaL (Vital)

Zareen M. Farukhi, Heike Gibson, Nancy R. Cook, Olga Demler et autres

Background: It is unclear if lipoprotein(a) cholesterol (LpaC), the cholesterol carried by Lpa, is associated with CVD similar to Lpa mass, and if omega-3 fatty acids (n-3 FA) modify risk. Methods: 13,175 participants of the VITAL trial (NCT01169259) had baseline LpaC measured …

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Abstract 16278: Discordant Lipid Phenotype and Other Determinants of Statin Response in the Pravastatin Inflammation/crp Evaluation (PRINCE) Trial

Oluremi N Ajala, Olga Demler, Yanyan Liu, Paul M. Ridker et autres

Introduction: Wide variability in LDL-C change is observed with statins, yet determinants of statin response are uncertain. Methods: Participants were selected from the primary prevention cohort of the Pravastatin Inflammation/CRP Evaluation double-blind trial that randomized participants to pravastatin 40 mg/d or placebo …

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Targeting Inflammation to Reduce Residual Cardiovascular Risk

Oluremi N Ajala, Brendan M. Everett

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Anti‐Inflammatory HDL Function, Incident Cardiovascular Events, and Mortality: A Secondary Analysis of the JUPITER Randomized Clinical Trial

Oluremi N Ajala, Olga Demler, Yanyan Liu, Zareen M. Farukhi et autres

Background High‐density lipoprotein (HDL) cholesterol has inverse association with cardiovascular disease. HDL possesses anti‐inflammatory properties in vitro, but it is unknown whether this may be protective in individuals with inflammation. Methods and Results The functional capacity of HDL to inhibit oxidation of …

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Vitamin D supplements and marine omega-3 fatty acids and development of advanced cancer.

Paulette D. Chandler, Wendy Y. Chen, Oluremi N Ajala, Aditi Hazra et autres

1510 Background: Epidemiologic data suggest that vitamin D supplementation may reduce cancer mortality. We tested whether vitamin D and/or omega-3 supplementation reduces the incidence of advanced stage cancer at diagnosis or lethal cancer, and whether body mass index (BMI) modifies these associations. …

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Abstract P260: Determinants of Statin Response: A Secondary Analysis of the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER)

Oluremi N Ajala, Olga Demler, Yanyan Liu, Paul M. Ridker et autres

Introduction: Wide variability in LDLC change is observed with statins, yet determinants of statin response are uncertain. Hypotheses: Some markers of inflammation are associated with decreased statin response. Components of metabolic syndrome and older age are associated with better response. Methods: JUPITER …

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Fibroblast growth factor-21 levels in metabolic syndrome: Another instrument in a widening tool belt?

Oluremi N Ajala, Samia Mora

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Abstract 13310: Anti-Inflammatory HDL Function and Incident Cardiovascular/Death Events: A Secondary Analysis of the JUPITER Trial

Oluremi N Ajala, Olga Demler, Zareen M. Farukhi, Yanyan Liu et autres

Background: HDL cholesterol (HDLC) is an established marker of cardiovascular risk that possesses anti-inflammatory properties in vitro. It is unclear whether the anti-inflammatory quality of HDL i...

Decreased serum TRAIL is associated with increased mortality in smokers with comorbid emphysema and coronary artery disease

Oluremi N Ajala, Yingze Zhang, Aman Gupta, Jessica M. Bon et autres

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Ideal Cardiovascular Health Metrics in Couples: A Community‐Based Study

Sebhat A. Erqou, Oluremi N Ajala, Claudia Bambs, Andrew D. Althouse et autres

BACKGROUND: Determination of the correlation of ideal cardiovascular health variables among spousal or cohabitating partners may guide the development of couple-based interventions to reduce cardiovascular disease risk. METHOD AND RESULTS: , physical activity at goal, diet consistent with guidelines, untreated total cholesterol …

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Association of obstructive sleep apnea with microvascular endothelial dysfunction and subclinical coronary artery disease in a community-based population

Daniel Shpilsky, Sebhat A. Erqou, Sanjay R. Patel, Kevin E. Kip et autres

Studies have reported an association between obstructive sleep apnea (OSA) and cardiovascular disease (CVD) morbidity and mortality. Proposed mechanisms include endothelial dysfunction and atherosclerosis. We aimed to investigate the associations of OSA with endothelial dysfunction and subclinical atherosclerotic coronary artery disease (CAD), …

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