Ravi Rajakariar

PO:10:252 A retrospective study of biopsy-proven lupus nephritis: steroid withdrawal, treatment patterns, and ethnic variations at barts health lupus centre

Evie Watts, Rania Ali, Luxme Nadarajah, Dev Pyne et autres

Objectives Lupus nephritis (LN) is one of the most common and challenging manifestations of systemic lupus erythematosus, frequently requiring prolonged immunosuppressive therapy. Achieving disease control while minimising steroid exposure remains a key treatment challenge. Understanding the factors that influence safe steroid withdrawal …

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P056 Analysis of antibody response to SARS-CoV-2 vaccination and natural infection in a tertiary centre cohort of lupus nephritis patients

Katie Townsend, Andrea Cove‐Smith, Ravi Rajakariar, Angéla Pákozdi et autres

Abstract Background/Aims The immune response to SARS-CoV-2 is known to be reduced in the immunocompromised. However, extent to which immunity is affected by immunosuppression in specific disease cohorts remains poorly characterised. Furthermore, implications of the ongoing vaccination booster programme require further study. …

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Outcome and effect of vaccination in SARS-CoV-2 Omicron infection in hemodialysis patients: a cohort study

Damien R. Ashby, Ben Caplin, Richard Corbett, Elham Asgari et autres

BACKGROUND: Hemodialysis patients are at high risk of Covid-19, though vaccination has significant efficacy in preventing and reducing the severity of infection. Little information is available on disease severity and vaccine efficacy since the dissemination of the Omicron variant. METHODS: In a …

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P162 Incidence of neutropaenia and infections in lupus patients on immunosuppression

Sotiria Manou-Stathopoulou, William D. Hann, Angéla Pákozdi, Ravi Rajakariar et autres

Abstract Background/Aims Neutropaenia occurs in 20-40% of patients with systemic lupus erythematosus (SLE) and is attributed to a combination of autoimmune and complement-mediated destruction of white cells, increased neutrophil apoptosis and medication side-effects. Commonly when patients become neutropaenic (<2x10^9/L), immunosuppressant doses are …

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Concurrent granulomatous polyangiitis and squamous cell carcinoma of the lung: a case of balancing treatment

Duncan Alston, Ravi Rajakariar, Michael T. Sheaff, Nick Lever

Granulomatous polyangiitis (GPA) is a rare small-vessel vasculitis characterised by lesions in the upper respiratory tract, lungs and kidneys. Diagnosis of lung lesions can be difficult and misdiagnosis as lung cancer is not uncommon.1 Aggressive, long-term immunosuppression with drugs such as cyclophosphamide …

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FP863INPATIENT VERSUS OUTPATIENT RENAL TRANSPLANT BIOPSY: A RETROSPECTIVE STUDY COMPARING COMPLICATION RATES

Saurabh Chaudhri, Vasantha Muthu Muthuppalaniappan, Samuel H. Hui, Liz Kuffer et autres

Introduction and Aims: Renal biopsy is an essential diagnostic tool widely used in managing renal transplant recipients. Major complications defined as bleeding requiring intervention has a complication rate reported between 0.4-1.0%. These studies are from outpatient elective protocol biopsies done in a …

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Recruitment of renal transplant patients into patrolling police roles using orthotic shields

Sara Levene, C. Levene, David Makanjuola, Ravi Rajakariar

Renal allografts are transplanted to an anatomically unnatural site where they are exposed to trauma, and may fail if damaged. Individuals with renal allografts have been excluded from patrolling police roles as these often necessitate confrontation. We describe two patients with renal …

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Infliximab as long-term maintenance in steroid-resistant and recurrent sarcoidosis in a renal transplant with central nervous system involvement

Sonal Srivastava, Ravi Rajakariar, Neil Ashman, Martin Raftery et autres

Sarcoidosis is a multisystemic, granulomatous disease of unknown aetiology, which commonly involves the lungs, skin and the eyes. Renal sarcoidosis is rare. Recurrent renal sarcoidosis leading to transplant graft failure in adults has not been reported. We report a single case of …

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Lymphoma masquerading as a peritoneal dialysis catheter leak

Anthony W. Solomon, Ravi Rajakariar, Michael Sheaff, Stanley Fan

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