Christian Kjer Heerfordt

Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis After Initiation of Antiseizure Medication

Ida Marie Heerfordt, Mette Mogensen, Anna Horwitz, Jón Trærup Andersen et autres

BACKGROUND AND OBJECTIVES: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious cutaneous adverse reactions associated with several antiseizure medications, particularly lamotrigine and carbamazepine. We assessed the 90-day absolute risk of SJS/TEN after initiation of antiseizure medications in a nationwide Danish …

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From viral injury to chronic instability: recurrent COPD exacerbations after COVID-19

Christian Kjer Heerfordt, Niklas Dyrby Johansen, Tor Biering-Sørensen, Pradeesh Sivapalan

Respiratory infections have long been recognised as acute triggers of chronic obstructive pulmonary disease (COPD) exacerbations.1 Increasing evidence, however, suggests that severe infections may also influence the longer-term trajectory of the disease.2 Through persistent airway inflammation, immune dysregulation, and structural lung injury, …

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Titel: Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Among Patients Treated With Immune Checkpoint Inhibitors Compared to Other Antineoplastic Medications: A Nationwide Study

Ida Marie Heerfordt, Magnus Middelboe, Christian Kjer Heerfordt, Henrik Horwitz et autres

PURPOSE: This study aimed to assess the risk of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) among patients treated with immune checkpoint inhibitors (ICIs), compared to those receiving molecularly targeted therapies or conventional chemotherapy, using real-world data. METHODS: We conducted a nationwide …

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Passive immunotherapy for adults hospitalized with COVID-19: An individual participant data meta-analysis of six randomized controlled trials

Kirk U. Knowlton, Lianne K. Siegel, Christina E. Barkauskas, Sanjay R. Bhagani et autres

BACKGROUND: Anti-SARS-CoV-2 monoclonal antibodies (mAb) reduce the risk of hospitalization in outpatients with mild-to-moderate COVID-19. However, the efficacy of treatment with mAbs and other passive immunotherapies in patients hospitalized with severe COVID-19 is not clear. The objective of this study was to …

us, gb, au, dk, Ouganda, ca, sg, gr (code pays fourni par la source)

Passive Immunotherapy for Adults Hospitalized with COVID-19: An Individual Participant Data Meta-Analysis of Six Double-Blind, Randomized, Placebo-Controlled Trials

Kirk U. Knowlton, Lianne K. Siegel, Christina E. Barkauskas, Sanjay R. Bhagani et autres

us, gb, au, dk, sg, in, gr (code pays fourni par la source)

Inhaled Corticosteroids Particle Size and Risk of Hospitalization Due to Exacerbations and All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease. A Nationwide Cohort Study

Christian Kjer Heerfordt, Christian Philip Rønn, Josefin Viktoria Eklöf, Pradeesh Sivapalan et autres

Background: Extra-fine particle inhaled corticosteroids (ICS) improve peripheral airway distribution, but their effect on risk of exacerbations and all-cause mortality in patients with chronic obstructive pulmonary disease (COPD) is unclear. Methods: This observational cohort study compares patients with COPD who received extra-fine …

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Inhaled corticosteroids andStenotrophomonas maltophiliain outpatients with chronic obstructive pulmonary disease: a retrospective cohort study

Christian Philip Rønn, Peter Thobias Kamstrup, Christian Kjer Heerfordt, Pradeesh Sivapalan et autres

Objectives Inhaled corticosteroids (ICS) are widely used in patients with chronic obstructive pulmonary disease (COPD). However, ICS are associated with an increased risk of adverse effects. We aimed to determine whether an association between a lower respiratory tract culture withStenotrophomonas maltophiliaand increasing …

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Viral and Host Factors Are Associated With Mortality in Hospitalized Patients With COVID-19

Neil R. Aggarwal, Jacquie Nordwall, Dominique L. Braun, Lucy K. Chung et autres

BACKGROUND: Persistent mortality in adults hospitalized due to acute COVID-19 justifies pursuit of disease mechanisms and potential therapies. The aim was to evaluate which virus and host response factors were associated with mortality risk among participants in Therapeutics for Inpatients with COVID-19 …

us, ch, Nigéria, es, dk, gb, gr (code pays fourni par la source)

Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19

Tomas Østergaard Jensen, Greg Grandits, Mamta K. Jain, Thomas A. Murray et autres

BACKGROUND: Neutralizing monoclonal antibodies (nmAbs) failed to show clear benefit for hospitalized patients with coronavirus disease 2019 (COVID-19). Dynamics of virologic and immunologic biomarkers remain poorly understood. METHODS: Participants enrolled in the Therapeutics for Inpatients with COVID-19 trials were randomized to nmAb …

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Extra-fine Particle Inhaled Corticosteroids Influence on the Risk of Hospitalization due to Pneumonia in Patients with Chronic Obstructive Pulmonary Disease - A Populations-Based Cohort Study

Christian Kjer Heerfordt, Christian Philip Rønn, Zitta Barrella Harboe, Pradeesh Sivepalan et autres

Background Inhaled corticosteroids (ICS) are associated with an increased risk of pneumonia among patients with chronic obstructive pulmonary disease (COPD). In recent years, ICS formulated as extra-fine particles have been introduced to improve the distribution of medicine in the airways. It remains …

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Inhalation devices and inhaled corticosteroids particle size influence on severe pneumonia in patients with chronic obstructive pulmonary disease: a nationwide cohort study

Christian Kjer Heerfordt, Christian Philip Rønn, Zitta Barrella Harboe, Truls Sylvan Ingebrigtsen et autres

BACKGROUND: Inhaled corticosteroids (ICSs) are associated with an increased risk of pneumonia among patients with chronic obstructive pulmonary disease (COPD). The introduction of extrafine particle ICS has aimed to improve the distribution of medicine in the airways by altering deposition within the …

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Inhaled corticosteroids and risk of lower respiratory tract infection withMoraxella catarrhalisin patients with chronic obstructive pulmonary disease

Rikke Helin Johnsen, Christian Kjer Heerfordt, Jonas Bredtoft Boel, Ram Benny Dessau et autres

Background Use of inhaled corticosteroids (ICS) is common in patients with chronic obstructive pulmonary disease (COPD) and has been associated with an increased risk of pneumonia.Moraxella catarrhalisis one of the most common bacterial causes of infectious exacerbation in COPD. Currently, to our …

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