Victor Feliciano dos Santos Ramos

Synthesis of Naphthoquinones by Pd‐Catalyzed Heck–Matsuda Arylation of Lapachol

Breno U. Abreu, Renata Almeida, Ana L. C. Silveira, Leonardo A. Matos et autres

Direct Heck–Matsuda arylation of lapachol provides rapid access to structurally diverse naphthoquinones under homogeneous and heterogeneous palladium catalysis. The methodology features broad substrate scope, gram‐scale applicability, and unambiguous structural assignment by single‐crystal X‐ray diffraction, providing an efficient platform for the diversification of …

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Synthesis, characterization, DNA interaction studies, and biological evaluation of copper(II) hybrids containing azole drugs and intercalating ligands against neglected diseases

José Aleixo de Azevedo-França, Victor Feliciano dos Santos Ramos, Patrícia Salvador Tessaro, Heveline Silva et autres

In an attempt to treat neglected diseases such as leishmaniasis and fungal infections, three novel copper(II) hybrid have been developed: [Cu(dppz)(CTZ)(NO3)](NO3) (1), [Cu(dppz)(KTZ)(H2O)(NO3)](NO3) (2), and [Cu(dppz)(FLZ)(NO3)]2(NO3)2 (3). They were synthesized by coordinating antifungal imidazole based drugs and dipyridophenazine as ligands to copper(II) …

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Bioemulsifier from sponge-associated bacteria reduces staphylococcal biofilm

Gabriel Rodrigues Dias, Jéssyca Freitas‐Silva, Marianna Machado de Carvalho, Victor Feliciano dos Santos Ramos et autres

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Synthesis, characterization, and biological evaluation of hybrid copper( ii ) complexes containing azole drugs and planar ligands against neglected diseases

José Aleixo de Azevedo-França, Victor Feliciano dos Santos Ramos, Luigi Messori, Fabio Santanni et autres

Motivated by the urgent need to find new medications for the treatment of neglected diseases, six copper( ii ) hybrid containing azole drugs and planar ligand were developed and tested against leishmania parasites and fungi.

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Use of Cell Biology to Identify Cellular Targets in Drug Development Process against Leishmania Sp.

Gabrielle dos Santos da Silva e Miranda, Joseane Lima Prado Godinho, Sara Teixeira de Macedo-Silva, Brunno Renato Farias Verçoza et autres

Leishmaniasis is one of the most important neglected tropical diseases. The chemotherapy for its treatment uses very toxic compounds with a low efficacy rate. Thus, there is an urgent need to develop new chemotherapeutic agents to help countries control this devasting disease. …

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