Shermyn Neo

Neuropsychiatric outcomes after deep brain stimulation for Parkinson's disease – Real-world data from a national movement disorders unit

Lip Jie Saw, Lai Gwen Chan, Wei Li, Hwee Lan Ng et autres

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Longitudinal MRI study of hippocampal subfields Morphometry in early Parkinson's disease

Tingyu Wu, Samuel Yong-Ern Ng, Thomas Wei Jun Teo, Xinyi Choi et autres

BACKGROUND: Parkinson's Disease (PD) is a neurodegenerative disorder characterised by motor and non-motor symptoms. Cognitive impairment is a prominent non-motor feature. OBJECTIVE: This study investigated hippocampal subfield shape deformation and atrophy in early-stage PD using spherical harmonic-based shape analysis. METHODS: Our cohort …

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Machine learning integration of serial blood biomarkers enhances cognitive decline prediction in early Parkinson’s disease

Raziyeh Mohammadi, Samuel Y. E. Ng, Jayne Yi Tan, Adeline S. L. Ng et autres

Cognitive decline is a major non-motor complication in early Parkinson's disease (PD), but predicting its progression remains challenging. Using data from 193 participants in the Early Parkinson's Disease Longitudinal Singapore (PALS) cohort, we evaluated whether repeated blood biomarker measurements (baseline, year 3, …

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Association between subthalamic nucleus volume and outcomes one year after bilateral subthalamic nucleus deep brain stimulation for Parkinson’s disease

Yilong Zheng, Yi Cai, Li Wei, Seyed Ehsan Saffari et autres

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A longitudinal study on physical activity in early Parkinson's disease

Samuel Yong‐Ern Ng, Darakhshan Naheed, Seyed Ehsan Saffari, Nicole Shuang Yu Chia et autres

Physical activity (PA) remains critical in the slowing of disease progression in early Parkinson's disease (PD), although the longitudinal follow-up of such studies remain scarce. Using data from an early PD Cohort, we longitudinally examined the impact of unprescribed PA on symptoms …

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Stuttering and Dystonia: Is There a Possible Overlap?

Shermyn Neo, Elina Tripoliti, Elie Matar, Bettina Balint et autres

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Table S1. Comparison of stuttering and dystonia. Table S2. Suggested protocol for speech …

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Machine Learning Integration of Serial Blood Biomarkers Enhances Cognitive Decline Prediction in Early Parkinson's Disease

Raziyeh Mohammadi, Samuel Yong‐Ern Ng, Jayne Yi Tan, Adeline Su Lyn Ng et autres

sg, us, gb (code pays fourni par la source)

How to Transition from a Movement Disorder Fellowship to an Academic Position

Daniel G. Di Luca, Carolina Gorodetsky, Blas Couto, Conor Fearon et autres

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

us, ca, ar, ie, sa, Égypte, Afrique du Sud, th, sg (code pays fourni par la source)

Carriers of Parkinson’s disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study

Aarthi Santhanakrishnan, Yi Jayne Tan, Seyed Ehsan Saffari, Yi Zhao et autres

= 0.001), highlighting the utility of Rep1 polymorphism in stratifying patients at risk of non-motor symptom decline.

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Assessment of social isolation and changes in Parkinson’s disease symptoms during the COVID-19 pandemic: A longitudinal study

Anish Mehta, Samuel Yong‐Ern Ng, Shermyn Neo, Nicole Shuang Yu Chia et autres

Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease. Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R). Methods: Data …

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Machine Learning for Early Detection of Cognitive Decline in Parkinson’s Disease Using Multimodal Biomarker and Clinical Data

Raziyeh Mohammadi, Samuel Yong‐Ern Ng, Jayne Yi Tan, Adeline Su Lyn Ng et autres

Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease, primarily affecting the middle-aged to elderly population. Among its nonmotor symptoms, cognitive decline (CD) is a precursor to dementia and represents a critical target for early risk assessment and diagnosis. Accurate …

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Novel Biallelic Synonymous Exonic Variant in VPS13A Affecting mRNA Splicing

Rebecca Hui Min Hoe, Yi Zhao, Helen Lisa Ong, Karine Su Shan Tay et autres

Objectives: . We identified a novel synonymous exonic variant leading to abnormal mRNA splicing in a patient with chorea-acanthocytosis. Methods: , mRNA splicing analysis, and Western blot for chorein were performed. Results: (NM_033305.3): c.5157C>T; p.Gly1719 = was identified; this was previously classified …

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