Accès ouvert
2023
article
OpenAlex
Sarah Bitzer, Mozhgan Dehghan Harati, Karim Christian El Kasmi, Daniela Schloesser et autres
Macrophages play a pivotal role in drug discovery due to their key regulatory functions in health and disease. Overcoming the limited availability and donor variability of human monocyte-derived macrophages (MDMs), human induced pluripotent stem cell (iPSC)-derived macrophages (IDMs) could provide a promising …
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Accès ouvert
2021
article
OpenAlex
Teresa Bluhmki, Stefanie Traub, Ann-Kathrin Müller, Sarah Bitzer et autres
In order to circumvent the limited access and donor variability of human primary alveolar cells, directed differentiation of human pluripotent stem cells (hiPSCs) into alveolar-like cells, provides a promising tool for respiratory disease modeling and drug discovery assays. In this work, a …
de
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Accès ouvert
2020
article
OpenAlex
Teresa Bluhmki, Sarah Bitzer, Julia A. Gindele, Eva Schruf et autres
In order to overcome the challenges associated with a limited number of airway epithelial cells that can be obtained from clinical sampling and their restrained capacity to divide ex vivo, miniaturization of respiratory drug discovery assays is of pivotal importance. Thus, a …
de
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