Accès ouvert
2026
article
OpenAlex
Tatiana V. Nekrasova, L. V. Aleshina, Elena N. Bobrikova, Е. А. Викторова et autres
Background: Hereditary angioedema (HAE) caused by C1 inhibitor deficiency is a rare condition marked by recurrent swelling of the skin and mucous membranes. This study evaluated the effectiveness and safety of lanadelumab in routine clinical practice in Russia (IISR-2021-200085). Methods: A prospective …
ru, us
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Elena Gracheva, Abigail Matt, Fei Wang, Raymond Hsin et autres
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a disease that causes deterioration of small vessels, affecting various organs: eyes, brain, liver, and others. The RVCL-S carriers have lower life expectancy. There is no cure available to date. The disease …
us
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Elena Gracheva, Abigail Matt, Fei Wang, Raymond Hsin et autres
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a disease that causes deterioration of small vessels, affecting various organs: eyes, brain, liver, and others. The RVCL-S carriers have lower life expectancy. There is no cure available to date. The disease …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Elena Gracheva, Abigail Matt, Fei Wang, Raymond Hsin et autres
Abstract Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a disease that causes deterioration of small vessels, affecting various organs: eyes, brain, liver, and others. The RVCL-S carriers have lower life expectancy. There is no cure available to date. The …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Elena Gracheva, Yuxuan Wang, Jiantao Zhu, Fei Wang et autres
In order to facilitate cardiovascular research to develop non-invasive optical heart pacing methods, we have generated a double-transgenic Drosophila melanogaster (fruit fly) model suitable for optogenetic pacing. We created a fly stock with both excitatory H134R-ChR2 and inhibitory eNpHR2.0 opsin transgenes. Opsins …
us
(code pays fourni par la source)
2024
conference-paper
OpenAlex
Xiangping Ouyang, Abigail Matt, Fei Wang, Elena Gracheva et autres
The Drosophila Melanogaster is a powerful tool for cardiac research due to its ability for disease modeling. OCM provides cross-sectional images of its beating heart tube, which can be segmented to quantify heart parameters. Here, we expanded upon an optimized LSTM U-Net …
us
(code pays fourni par la source)
2024
conference-paper
OpenAlex
Marcello Magri Amaral, Abigail Matt, Fei Wang, Elena Gracheva et autres
Cardiac optogenetics is an emerging tool to treat and model arrythmia noninvasively using light. Mice expressing ReaChR in cardiac tissue are optically stimulated using novel LED array design, providing noninvasive, tunable cardiac pacing in vivo.
us, br
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Olga Shchagina, Elena Gracheva, Alyona L. Chukhrova, E. A. Bliznets et autres
Variants that affect splice sites comprise 14.3% of all pathogenic variants in the SERPING1 gene; more than half of them are located outside the canonical sites. To make a clinical decision concerning patients with such variants, it is essential to know the …
ru
(code pays fourni par la source)
Accès ouvert
2023
data-paper
OpenAlex
Matthew Fishman, Abigail Matt, Fei Wang, Elena Gracheva et autres
The heart of the fruit fly, Drosophila melanogaster, is a particularly suitable model for cardiac studies. Optical coherence microscopy (OCM) captures in vivo cross-sectional videos of the beating Drosophila heart for cardiac function quantification. To analyze those large-size multi-frame OCM recordings, human …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Elena A. Latysheva, Irina A. Manto, L. V. Aleshina, Elena N. Bobrikova et autres
BACKGROUND: Hereditary angioedema with C1 inhibitor deficiency is a rare disease caused by a deficiency and/or a decrease in the functional activity of the C1 inhibitor. The primary symptom of this condition is recurrent angioedema of various localizations. According to the modern …
ru, hr
(code pays fourni par la source)
2023
conference-paper
OpenAlex
Fei Wang, Elena Gracheva, Abigail Matt, Hongwu Liang et autres
Optogenetics allows non-invasive control of cardiac function by inducing physiological heart distress. The main challenge for optogenetic pacing is relatively shallow light penetration into biological tissue. Recently, ChRmine was reported as an excitatory opsin that can respond to much lower light power …
us
(code pays fourni par la source)
2023
conference-paper
OpenAlex
Abby Matt, Hongwu Liang, Matthew Fishman, Elena Gracheva et autres
Noninvasive cardiac control has stemmed from a need to overcome challenges that come from traditional electric implantable pacemakers, which can require surgery, cause infection and damage to vessels, and require battery replacements. Therefore, new methods are being developed to be able to …
us
(code pays fourni par la source)