Sławomir Wołczyński

EP468 - ECE_2754 - Molecular mechanisms of liver injury induced by selective progesterone receptor modulator ulipristal acetate

Aleksandra Lupinska, Donata Ponikwicka‐Tyszko, Oana Lupu, Weronika Lebiedzińska et autres

Abstract Drug-induced liver injury (DILI) is a major in clinical and drug development challenge due to its unpredictable nature. While most of the research focus on direct hepatotoxicity, the role of the endocrine signaling in DILI susceptibility remains largely underexplored. As the …

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RC4.5 - ECE_2775 - The anti-Müllerian hormone suppresses uterine leiomyoma growth via a miR-181a-regulated molecular switch

Oana Lupu, Gabriela Milewska, Donata Ponikwicka‐Tyszko, Piotr Bernaczyk et autres

Abstract Uterine leiomyomas (ULs) are common, benign neoplasms, in women of reproductive age. ULs may cause severe anemia, after heavy menstrual bleeding, pelvic pain, infertility and significant morbidity, often necessitating invasive, surgical intervention. Despite their prevalence, the pathogenesis of ULs remains not …

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Imazalil at high plasma concentrations: implications for neutrophil immunophenotype

Wioletta Ratajczak-Wrona, Małgorzata Rusak, Olga Diana Drezek, Joanna Chociej-Stypułkowska et autres

neutrophils. No changes in the percentage of neutrophils expressing the analyzed molecules were observed in the presence of testosterone. In conclusion, imazalil modulates the neutrophil immunophenotype, which may inhibit functions such as adhesion, migration, chemotaxis, and phagocytosis. Consequently, this may predispose individuals …

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“Protective” Imazalil vs Its Negative Effects on Immune System Cells—Neutrophils

Wioletta Ratajczak-Wrona, Aleksandra Aniszewska, Agnieszka Iwaniuk, Marzena Garley et autres

Neutrophils are the most numerous population of peripheral blood leukocytes and play a key role in innate immunity, participating in antibacterial, antifungal, antiviral, and antitumor responses. Their activity can be modulated by endogenous and exogenous factors, including pesticides, among which fungicides such …

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Progesterone and selective progesterone receptor modulator regulate tumor-associated fibroblasts in uterine leiomyomas

Weronika Szucio, Gabriela Milewska, M. Szamatowicz, Weronika Lebiedzińska et autres

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Chromosome-associated spot formation by human cytomegalovirus immediate early 1 (IE1) protein

Mamata Savanagouder, Martin Messerle, Eva Maria Borst, Thomas F. Schulz et autres

Summary HCMV is associated with severe disease in immunocompromised patients and is a cause of congenital disease. Already more than 30 years ago, IE1 was described to bind to mitotic chromosomes, however the implications of this finding have yet to be determined. …

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Beneficial Effects of Antioxidants in Regulating NET Generation Within the Course of Atherosclerosis

Dorota M. Dabrowska, Marzena Garley, Wioletta Ratajczak–Wrona, Kamil Grubczak et autres

Introduction: Neutrophils have been implicated in the pathogenesis of atherosclerosis in multiple studies. This study aimed to determine the effects of flavonoids (quercetin and luteolin) and vitamin C on neutrophil extracellular trap (NET) formation and regulation of NET markers, including circulating cell-free …

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Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma

Shenghong Wang, Peilan Guo, Wenqiang Ma, Honglin Huang et autres

RNA-binding proteins (RBPs) serve as key regulators of hepatocellular carcinoma (HCC); however, the specific mechanisms by which RBPs function in this context require clarification. Here, we identify an RBP, ATXN2L (ataxin 2-like), that is significantly upregulated in HCC tissues and correlates with …

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Circular RNA CLASP1 modulates the GLI1/SNAIL axis and enhances macrophage polarization in breast cancer

Li-Jun Zhou, Mei Liu, Fujun Liu, Zhengkun Wang et autres

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CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target

Peilan Guo, Xiaomeng Jia, Shenghong Wang, Xinyu Li et autres

The mechanism underlying metabolic dysfunction-associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC) is elusive, and whether circRNA can serve as biomarker or therapeutic target for MASH/HCC needs to be systematically explored. Integrative transcriptomic analysis of circRNA from MASH and HCC were performed. Multi-cohort …

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miR-423-3p inhibits CTNNBIP1/WNT preventing hyperandrogenic polycystic ovary syndrome

Yajing Liu, Mingming Wang, Donata Ponikwicka‐Tyszko, Sławomir Wołczyński et autres

Polycystic ovary syndrome (PCOS) lacks the generally accepted diagnostic biomarkers and targeted therapy. Increasing evidence indicates that microRNAs play a crucial role in PCOS. Hereby, we tested the functional implications of a novel MicroRNA (miR-423-3p) as a mediator in the progress of …

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Targeted destruction of follicle stimulating hormone receptor-positive cancer cells in vitro and in vivo by a lytic peptide Phor21-FSHβ conjugate

Nafis A. Rahman, Marcin Chruściel, Donata Ponikwicka‐Tyszko, Kamila Puławska et autres

BACKGROUND: Extragonadal follicle-stimulating hormone (FSH) receptor (FSHR) expression in various cancers and their endothelial vessel cells has highlighted novel opportunities for targeted FSHR therapy. METHODS: We investigated the specificity/cytotoxicity of Phor21 fusion lytic peptide, conjugated to 12 different FSHβ-chain fragments to ablate …

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