Christopher E. Mandigo

Surgical treatment of myxopapillary ependymoma: an institutional case series of 56 patients

Evan F Joiner, Justin A. Neira, Andrew K Chan, Jane Kostadinov et autres

OBJECTIVE: The aim of this study was to review the management and outcomes of a consecutive cohort of patients with spinal myxopapillary ependymoma (MPE) treated at the authors' institution over a 23-year period. METHODS: A retrospective review of all patients treated surgically …

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Timing-dependent synergies between noninvasive motor cortex and spinal cord stimulation in chronic cervical spinal cord injury

Lynda M. Murray, James R. McIntosh, Jacob A. Goldsmith, Yu‐Kuang Wu et autres

OBJECTIVE: Spinal cord sensory networks strongly interact with descending motor circuits. We targeted this interaction by pairing motor cortex stimulation with coordinated cervical spinal cord stimulation. Using separate non-invasive and epidural experiments, we tested the hypothesis that the strongest muscle response would …

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Hierarchical Bayesian estimation of motor-evoked potential recruitment curves yields accurate and robust estimates

Vishweshwar Tyagi, Lynda M. Murray, Ahmet S. Asan, Christopher E. Mandigo et autres

PURPOSE: We aim to develop a robust method to improve the estimation accuracy of motor-evoked potential (MEP) recruitment curves (RCs), including motor threshold, in small-sample settings which typically involve fewer than 40 stimuli. METHODS: We present a hierarchical Bayesian (HB) method to …

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ID# 1902731 Comparison of epidural and transcutaneous spinal cord stimulation and their synergistic interaction with brain stimulation

Evan F. Joiner, James R. McIntosh, Lynda M. Murray, Jacob L. Goldberg et autres

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Timing-dependent synergies between noninvasive motor cortex and spinal cord stimulation in chronic cervical spinal cord injury

Lynda M. Murray, James R. McIntosh, Jacob A. Goldsmith, Yu‐Kuang Wu et autres

Abstract Precise movement requires integrating descending motor control with sensory feedback. Sensory networks interact strongly with descending motor circuits within the spinal cord. We targeted this interaction by pairing stimulation of the motor cortex with coordinated stimulation of the cervical spinal cord. …

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1210 Quantitative Analysis of Relationship Between Paraspinal Muscle Parameters and Degree of Degenerative Lumbar Spondylolisthesis

Weiwei Da, Qiang Jian, Andrew K. Chan, Evan F. Joiner et autres

INTRODUCTION: Degenerative spondylolisthesis (DS) is a common cause of lumbar stenosis and potentially dynamic instability that frequently causes radiculopathy. While paraspinal muscle degeneration is thought to contribute to spondylolisthesis severity, this relationship has yet to be fully characterized. METHODS: A retrospective analysis …

Quantitative Analysis of Relationship Between Paraspinal Muscle Degeneration and Degree of Degenerative Lumbar Spondylolisthesis

Weiwei Da, Qiang Jian, Joiner Evan, Andrew K. Chan et autres

STUDY DESIGN: Clinical retrospective study. OBJECTIVE: The authors aim to analyze the relationship between paraspinal muscle degeneration and degree of L4-5 Degenerative lumbar spondylolisthesis (DLS). SUMMARY OF BACKGROUND DATA: While paraspinal muscle degeneration is thought to contribute to spondylolisthesis severity, this relationship …

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ID: 330948 Invasive and Non-invasive Synergies Between Motor Cortex and Cervical Spinal Stimulation in Humans

James R. McIntosh, Lynda M. Murray, Evan F. Joiner, Jacob L. Goldberg et autres

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Timing‐dependent synergies between motor cortex and posterior spinal stimulation in humans

James R. McIntosh, Evan F. Joiner, Jacob L. Goldberg, Phoebe Greenwald et autres

Volitional movement requires descending input from the motor cortex and sensory feedback through the spinal cord. We previously developed a paired brain and spinal electrical stimulation approach in rats that relies on convergence of the descending motor and spinal sensory stimuli in …

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116 The Role of Spinal Surgery Among NF2 Patients With Spinal Tumors: Surgery-associated Characteristics and Response to Bevacizumab

Travis S. CreveCoeur, Colin Sperring, Richard L. Price, Justin A. Neira et autres

INTRODUCTION: Neurofibromatosis type 2 (NF2) patients develop spinal neoplasms. Determining indications for spine surgery remains challenging, as localization of spine related symptoms can be confounded by intracranial or peripheral neuropathology. Additionally, patient selection must be balanced with pre-existing comorbidities NF2 incurs with …

Timing dependent synergies between motor cortex and posterior spinal stimulation in humans

James R. McIntosh, Evan F. Joiner, Jacob L. Goldberg, Phoebe Greenwald et autres

Volitional movement requires descending input from motor cortex and sensory feedback through the spinal cord. We previously developed a paired brain and spinal electrical stimulation approach in rats that relies on convergence of the descending motor and spinal sensory stimuli in the …

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ID: 219111 Guided Intraoperative Dorsal Root Entry Zone Stimulation Facilitates Cortical Motor Evoked Potentials in Humans

James R. McIntosh, Evan F. Joiner, Jacob L. Goldberg, Lynda M. Murray et autres