Ieva Rinkūnaitė

Development of multilayered artificial urethra graft for urethroplasty

Povilas Barasa, Egidijus Šimoliūnas, Aivaras Grybas, Ramunė Žilinskaitė-Tamašauskė et autres

To enhance the treatment of patients' urethral defects, such as strictures and hypospadias, we investigated the potential of using artificial urethral tissue. Our study aimed to generate this tissue and assess its effectiveness in a rabbit model. Two types of bioprinted grafts, …

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Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas

Egidijus Šimoliūnas, Inés Ruedas‐Torres, Yolanda Jiménez, Elle Edin et autres

Pathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately blindness. We developed an injectable Cornea-in-a-Syringe (CIS) sealant-filler to treat damaged corneas. CIS comprises linear carboxylated polymers of inflammation-suppressing 2-methacryloyloxyethyl phosphorylcholine, regeneration-promoting collagen-like peptide, and …

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Surface Stiffness Has No Impact on MCF-7 Sensitivity to Doxorubicin

Egidijus Šimoliūnas, Daiva Jasmontaitė, Algimantas Skinderskis, Ieva Rinkūnaitė et autres

Resistance to the chemotherapeutic agents in the clinical management of cancer remains a significant challenge, and the mechanical environment of cancer cells is one of the major determinants of this. Stiffening of the environment is usually associated with increased chemoresistance of cancer …

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Synthesis and characterization of UV curable biocompatible hydrophilic copolymers containing siloxane units

Saulutė Budrienė, Tatjana Kochanė, Neringa Žurauskaitė, Evaldas Balčiūnas et autres

Tissues are highly three-dimensional structure complexes composed of different cell types and their interactions. One of the main challenges in tissue engineering is the inability to produce large, highly perfused scaffolds in which cells can grow at a high cell density and …

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Miokardito ir dilatacinės kardiomiopatijos molekulinių mechanizmų tyrimai

Ieva Rinkūnaitė

Study of molecular mechanisms of myocarditis and dilated cardiomyopathy

Genetic Ablation of Ankrd1 Mitigates Cardiac Damage during Experimental Autoimmune Myocarditis in Mice

Ieva Rinkūnaitė, Egidijus Šimoliūnas, Milda Alksnė, Gabrielė Bartkutė et autres

Myocarditis (MC) is an inflammatory disease of the myocardium that can cause sudden death in the acute phase, and dilated cardiomyopathy (DCM) with chronic heart failure as its major long-term outcome. However, the molecular mechanisms beyond the acute MC phase remain poorly …

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Dental pulp stem cell-derived extracellular matrix: autologous tool boosting bone regeneration

Milda Alksnė, Miglė Kalvaitytė, Egidijus Šimoliūnas, Ieva Gendvilienė et autres

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Inflammation-Related Biomarkers Are Associated with Heart Failure Severity and Poor Clinical Outcomes in Patients with Non-Ischemic Dilated Cardiomyopathy

Ieva Kažukauskienė, Vaida Baltrūnienė, Ieva Rinkūnaitė, Edvardas Žurauskas et autres

Inflammation-related biomarkers are associated with clinical outcomes in mixed-etiology chronic heart failure populations. Inflammation-related markers tend to be higher in ischemic than in non-ischemic dilated cardiomyopathy (NI-DCM) patients, which might impact their prognostic performance in NI-DCM patients. Therefore, we aimed to assess …

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The Effect of a Unique Region of Parvovirus B19 Capsid Protein VP1 on Endothelial Cells

Ieva Rinkūnaitė, Egidijus Šimoliūnas, Daiva Bironaitė, Rasa Rutkienė et autres

Parvovirus B19 (B19V) is a widespread human pathogen possessing a high tropism for erythroid precursor cells. However, the persistence or active replication of B19V in endothelial cells (EC) has been detected in diverse human pathologies. The VP1 unique region (VP1u) of the …

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Surface stiffness depended gingival mesenchymal stem cell sensitivity to oxidative stress

Egidijus Šimoliūnas, Indrė Ivanauskienė, Lina Bagdzevičiūtė, Ieva Rinkūnaitė et autres

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Anti-inflammatory effect of different curcumin preparations on adjuvant-induced arthritis in rats

Ieva Rinkūnaitė, Egidijus Šimoliūnas, Milda Alksnė, Dominyka Dapkutė et autres

BACKGROUND: Curcumin, a natural polyphenolic substance, has been known for more than two millennia as having strong anti-inflammatory activity towards multiple ailments, including arthritis. The main drawback of curcumin is its poor solubility in water, which leads to low intestinal absorption and …

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In vitro comparison of 3D printed polylactic acid/hydroxyapatite and polylactic acid/bioglass composite scaffolds: Insights into materials for bone regeneration

Milda Alksnė, Miglė Kalvaitytė, Egidijus Šimoliūnas, Ieva Rinkūnaitė et autres

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