R. Dayne Mayfield

Identification and validation of central amygdala FGFR1 as a therapeutic target for alcohol use disorder using single-nucleus sequencing in rats

Estelle Barbier, Leon Höglund, Li Xin Xu, Nihal A. Salem et autres

A significant minority of alcohol users develop alcohol addiction, characterized by continued use despite negative consequences, referred to as compulsive-like. We previously showed that vulnerability to compulsive-like alcohol use can be modeled in rats using punished alcohol self-administration and in male rats …

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Editorial: The role of transcriptomics in addiction

R. Dayne Mayfield, Laura M. Saba

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Translational evidence for increased central amygdala IL-6 activity in alcohol dependence

Celsey M. St. Onge, Chloe Michelle Erikson, Bryan Cruz, Vittoria Borgonetti et autres

Alcohol use disorder (AUD) is one of the most prevalent mental health disorders worldwide yet effective therapeutics remain limited. Mounting evidence indicates that dysregulated immune signaling in the brain plays a role in AUD pathophysiology. Activation of pro-inflammatory pathways like the interleukin-6 …

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Repeated TLR7 activation induces cell type- and brain region-specific transcriptome changes in male mice

Marion M. Friske, Riccardo Barchiesi, Nihal A. Salem, Ruth L. Allard et autres

Alcohol consumption triggers neuroinflammation, potentially creating a feed-forward loop that increases drinking. Previous studies have shown that activation of the toll-like receptor 7 (TLR7) leads to escalated drinking. In this study, we aim to identify cell type-specific transcriptomic patterns underlying TLR7-induced neuroinflammation, …

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Immunization with Mycobacterium vaccae attenuates age-associated transcriptional remodeling and microglial reactivity in the rat hippocampus

Steven P. Guerin, Kevin Sanchez, Arshia Verma, Nihal A. Salem et autres

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Conserved Cell-Type-Specific Transcriptomic Networks and Regulatory Programs Underlie Alcohol Dependence Across Mouse and Human

Nihal A. Salem, Anna S. Warden, Amanda Roberts, Marisa Roberto et autres

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BDNF signaling in the central amygdala: Implications for post-traumatic stress and alcohol use disorders

Celsey M. St. Onge, Bryan Cruz, Michela Palmisano, Chloe Michelle Erikson et autres

Elevated intron retention implicates neuroinflammation in brains of individuals with alcohol use disorder

Rudong Li, Jill L. Reiter, Season K. Wyatt‐Johnson, Chuanpeng Dong et autres

Abstract Intron retention, a form of alternative RNA splicing, can occur as part of normal gene regulation or result from disruption of the splicing machinery. Retained introns can potentially form double-stranded RNA, activating innate immune sensors and inflammation. This mechanism has been …

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Chronic alcohol consumption sex-dependently affects IL-6 modulation of GABAergic synapses in the central amygdala of rhesus macaques

Michal Bajo, Pauravi J. Gandhi, Suzanne S. Fei, Yun Yu et autres

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Conducting the Molecular Symphony: Network-Based Approaches to Substance Use Disorders

Anna S. Warden, R. Dayne Mayfield

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Astrocytes and Alcohol Throughout the Lifespan

Marina Guizzetti, Regina A. Mangieri, Lubov A. Ezerskiy, Joel G. Hashimoto et autres

Evidence for involvement of astrocytes in several neurodegenerative disorders and in drug addiction has been emerging over the last 2 decades, but only in recent years have astrocytes been investigated for their roles in alcohol use disorder (AUD). As a result, there …

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Integrative Genomics Approach Identifies Glial Transcriptomic Dysregulation and Risk in the Cortex of Individuals With Alcohol Use Disorder

Anna S. Warden, Nihal A. Salem, Eric A. Brenner, Greg T. Sutherland et autres

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