Qu Zheng

Mechanism of Yougui Pill （右归丸）-containing serum in inhibiting TNF-α-induced chondrocyte apoptosis through the p38 MAPK/NF-κB signaling pathway

Qu Zheng, Xingxing LIN, Yu Zhang, Xuefeng GUAN et autres

目的 研究右归丸通过丝裂原活化蛋白激酶p38- MAPK（p38- MAPK）/核因子-κB（NF-κB）信号通路调控肿瘤坏死因子-α（TNF-α）诱导软骨细胞自噬抑制凋亡的机制。 方法 选择大鼠原代软骨细胞细胞分为空白组、模型组、右归丸含药血清组、对照组。采用CCK8检测软骨细胞增殖；TUNEL法检测软骨细胞凋亡情况；ELISA法检测各组软骨细胞上清液中IL-1β、IL-6水平；免疫荧光法测定软骨细胞Beclin1、微管相关蛋白轻链3B（LC3B）表达、凋亡相关蛋白B淋巴细胞瘤-2（Bcl-2）、Bcl-2相关X蛋白（Bax）表达水平；Western blot法检测软骨细胞p-p38- MAPK，p-P65、Beclin1、LC3BⅡ/Ⅰ、Bcl-2、Bax、含半胱氨酸的天冬氨酸蛋白水解酶-3（Caspase-3）蛋白表达水平。 结果 与模型组相比，右归丸组和对照组软骨细胞增殖抑制率均较低（P<0.05），软骨细胞凋亡率均较低（P<0.05），软骨细胞上清液中IL-1β、IL-6水平较低（P<0.05），软骨细胞Bax表达水平均较低，Bcl-2、Beclin1、LC3B表达水平较高（P<0.05），软骨细胞p-p38- MAPK、p-P65、Bax、Caspase-3表达水平均较低，LC3BⅡ/Ⅰ较高（P<0.05），右归丸组与对照组上述指标相比无差异（P>0.05）。 结论 右归丸能够通过抑制p38-MAPK/NF-κB信号通路来调节软骨细胞自噬，抑制软骨细胞凋亡，减轻炎症反应，发挥软骨细胞保护作用。

Visual Acuity Alone Is Not Enough: The Need for Multimodal Biomarkers in Dominant Optic Atrophy

Yiyan Han, Lei Zhao, Tie-Ming Ma, Qu Zheng

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Acupuncture in Knee Osteoarthritis: A Narrative Review of Clinical Efficacy and Neuroimmune-Endocrine Mechanisms

J. B. Jiao, Bao-Qiang Dong, Yiyan Han, Qu Zheng et autres

Purpose: Knee osteoarthritis (KOA) is a leading cause of global pain and disability and warrants complementary therapy. This review provides evidence of the clinical efficacy of acupuncture and the multisystem regulatory mechanisms of KOA. Methods: We analyzed clinical trials and mechanistic studies …

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Commentary on “Liver function effects of SGLT2 inhibitor and GLP ‐1 receptor agonist combination treatment in patients with type 2 diabetes ( post hoc analysis of RECAP study)”

Yu Zhang, Yiyan Han, Qu Zheng, Xingxing Lin

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Limitations in targeting Modic type 1 changes with systemic TNF inhibition: comment on the article by Gjefsen et al

Qu Zheng, Bao-Qiang Dong, Xingxing Lin, Yiyan Han

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RE: Clinical and patient-reported outcomes after oncoplastic vs conventional breast-conserving surgery—a longitudinal, multicenter cohort study

Jilong Yuan, Qu Zheng, Peizhuo Zang

Jilong Yuan, MD, Qu Zheng, MD, Peizhuo Zang, MD; RE: Clinical and patient-reported outcomes after oncoplastic vs conventional breast-conserving surgery—a l

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RE: Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis

Qu Zheng, Bao-Qiang Dong, Yiyan Han

Qu Zheng, Bao-Qiang Dong, Yiyan Han, PhD; RE: Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis, JN

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A commentary on ‘Could nerve transplantation be the future of this field: a bibliometric analysis about lumbosacral plexus injury’

Yiyan Han, Qu Zheng, Tao Zuo

aLiaoning University of Traditional Chinese Medicine bAcupuncture Biology Key Laboratory of the Education Department of Liaoning Province, Liaoning, People's Republic of China Yiyan Han and Qu Zheng contributed equally to this study. Sponsorships or competing interests that may be relevant to content …

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A commentary on ‘The efficacy and safety of hydrotherapy in patients with knee osteoarthritis: a meta-analysis of randomized controlled trials’

Qu Zheng, Yiyan Han, Bao-Qiang Dong

aCollege of Integrated Traditional Chinese and Western Medicine, Liaoning University of Traditional Chinese Medicine, Liaoning, China, 110847 bAcupuncture and Moxibustion Massage College, Liaoning University of Traditional Chinese Medicine, Liaoning, China, 110847 Qu Zheng and Yiyan Han equally contributed to the study. All …

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AKT/foxo3a signal pathway mediates the protective mechanism of resveratrol on renal interstitial fibrosis and oxidative stress in rats with unilateral ureteral obstruction.

Rongrong Sun, Qu Zheng

OBJECTIVE: To explore whether protein kinase B (serine/threonrine kinase, AKT)/forkhead box protein O3a (foxo3a) pathway mediates the protective mechanism of resveratrol (RSV) on renal interstitial fibrosis (RIF) and oxidative stress. METHODS: Sprague-Dawley (SD) rats were grouped into Sham group, unilateral ureteral obstruction …

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Determination of iodine content of iodine-rich herbal and analysis of effective factors

Qu Zheng

Objective To determine the iodine content of iodine-rich herbal and analyze the effective factors. Methods Iodine contents of seaweed at different alkali ashing temperature,such as 200 ℃,300 ℃,400 ℃,500 ℃ and 600 ℃ were determined,then the optimum ashing temperature were selected. Mixed …

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