Aleš Goropevšek

Circulating Naïve Regulatory T Cell Subset Displaying Increased STAT5 Phosphorylation During Controlled Ovarian Hyperstimulation Is Associated with Clinical Pregnancy and Progesterone Levels

Ksenija Rakić, Aleš Goropevšek, Nejc Kozar, Borut Kovačič et autres

Regulatory T cells (Tregs), particularly their phenotypically distinct subpopulations, are critical for the establishment of maternal immune tolerance during embryo implantation. Despite advances in assisted reproductive technologies, implantation failure remains a frequent and often unexplained clinical challenge. Variations in Treg frequency and …

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Elevated circulating activated FOXP3+ regulatory T cell subset in patients with advanced chronic lymphocytic leukemia as a marker for severe infections during 1000 days of follow-up

Mojca Dreisinger, Zlatko Roškar, Matjaž Sever, Sebastjan Bevc et autres

Abstract Introduction. Patients with chronic lymphocytic leukemia (CLL) are more susceptible to infections, which remain the leading cause of death in this population. Previous studies have shown elevated levels of FOXP3+ regulatory T cells (Tregs) in CLL, which correlate with impaired T …

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Increased STAT3 Phosphorylation in CD4+ T-Cells of Treated Patients with Chronic Lymphocytic Leukemia and Changes in Circulating Regulatory T-Cell Subsets Relative to Tumor Mass Distribution Value and Disease Duration

Mojca Dreisinger, Zlatko Roškar, Aleš Goropevšek, Andreja Zakelšek et autres

Introduction: In mouse models of chronic lymphocytic leukemia (CLL), an effective anti-leukemia immune response was obtained by depleting a specific regulatory T-cell (Treg) subset. While STAT5 signaling could alter the homeostasis of naïve (nTreg) and activated (aTreg) subsets, which are capable of …

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Increased Frequency of Circulating Activated FOXP3+ Regulatory T Cell Subset in Patients with Chronic Lymphocytic Leukemia Is Associated with the Estimate of the Size of the Tumor Mass, STAT5 Signaling and Disease Course during Follow-Up of Patients on Therapy

Zlatko Roškar, Mojca Dreisinger, Evgenija Homšak, Tadej Avčin et autres

Introduction: Advanced chronic lymphocytic leukemia (CLL) is accompanied by increased circulating regulatory T cells (Tregs) and increased susceptibility to severe infections, which were also shown to entail a striking induction of FOXP3 expression in Tregs. As homeostasis of the most suppressive CD45RA−FOXP3high …

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Increased Frequency of Circulating Activated FOXP3+ Regulatory T-cell Subset in Patients with Chronic Lymphocytic Leukemia Is Associated with the Estimate of the Size of the Tumor Mass, STAT5 Signaling and Disease Course during Follow-Up of Patients

Zlatko Roškar, Mojca Dreisinger, Evgenija Homšak, Tadej Avčin et autres

Advanced chronic lymphocytic leukemia (CLL) is accompanied by increased circulating regula-tory T cells (Tregs) and increased susceptibility to severe infections, which were also shown to en-tail a striking induction of FOXP3 expression in Tregs. As homeostasis of the most suppressive CD45RA-FOXP3high activated …

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The role of regulatory T-cells in the development of endometriosis

Jure Knez, Borut Kovačič, Aleš Goropevšek

Endometriosis is a benign disease of the female reproductive tract, characterized by the process of chronic inflammation and alterations in immune response. It is estimated to affect 2-19% of women in the general population and is commonly associated with symptoms of chronic …

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New Flow Cytometric Methods for Monitoring STAT5 Signaling Reveal Responses to SARS-CoV-2 Antigen-Specific Stimulation in FOXP3+ Regulatory T Cells also in Patients with Advanced Chronic Lymphocytic Leukemia

Zlatko Roškar, Mojca Dreisinger, Primož Tič, Evgenija Homšak et autres

Increased frequency of CD4+CD25+ regulatory T-cells (Treg) has been associated with disease progression in chronic lymphocytic leukemia (CLL). Flow cytometric methods, which allow for the simultaneous analysis of their specific transcription factor Foxp3 and activated STAT proteins, together with proliferation can help …

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Case report: Pneumocystis jirovecii pneumonia in a severe case of Aicardi–Goutières syndrome with an IFIH1 gain-of-function mutation mimicking combined immunodeficiency

Mojca Železnik, Aneta Soltirovska Šalamon, Maruša Debeljak, Aleš Goropevšek et autres

Aicardi–Goutières syndrome (AGS) is a genetically determined early-onset progressive encephalopathy caused by mutations leading to overexpression of type I interferon (IFN) and resulting in various clinical phenotypes. A gain-of-function (GOF) mutation in the IFIH1 gene is associated with robust production of type …

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P-392 Peripheral blood naïve Treg (nTreg) cell subsets and implantation success in patients undergoing in vitro fertilization (IVF) treatment

Ksenija Rakić, Aleš Goropevšek, Borut Kovačič, Milan Reljič

Abstract Study question Which populations of circulating Treg cells, based on immunophenotyping with thirteen color flow cytometry and analysis with clustering algorithms play a role in implantation? Summary answer The phenotype of subpopulation within Treg cells that was most significantly increased in …

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O-030 Disturbed homeostasis of regulatory T-cells and imbalanced signal transducer and activator of transcription 5 (STAT5) in women with ovarian endometriosis

Jure Knez, Leyla Al Mahdawi, Borut Kovačič, Igor But et autres

Abstract Study question Do women with endometriosis have altered cytokine signalling and regulatory T-cell (Treg) homeostasis compared to controls? Summary answer Altered homeostasis of circulating Treg cells seems to be associated with STAT5 phosphorylation, which is significantly increased in women with ovarian …

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Altered Homeostasis of Regulatory T Lymphocytes and Differential Regulation of STAT1/STAT5 in CD4+ T Lymphocytes in Childhood-onset Systemic Lupus Erythematosus

Marija Holcar, Aleš Goropevšek, Tadej Avčin

OBJECTIVE: Childhood-onset systemic lupus erythematosus (cSLE) is usually a more severe and aggressive disease than adult-onset SLE (aSLE), but cellular and subcellular reasons for these differences are not well understood. The present study analyzed Th subsets, STAT1/STAT5 signaling response, and cytokine profiles …

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STAT signaling as a marker of SLE disease severity and implications for clinical therapy

Aleš Goropevšek, Marija Holcar, Artur Pahor, Tadej Avčin

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