Yudong Cui

Ultrahigh-energy gamma-ray emission associated with black hole-jet systems.

Z. Cao, F Aharonian, D. Bastieri, X. J. Bi et autres

Black holes (BHs), one of the most intriguing objects in the universe, can manifest themselves through electromagnetic radiation initiated by the accretion flow. Some stellar-mass BHs drive relativistic jets when accreting matter from their companion stars, forming microquasars. Non-thermal emission from the …

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Immunogenicity Evaluation of Epitope-Based Vaccine on Target of RNAIII-Activating Protein (TRAP) of Staphylococcus Aureus

Simiao Yu, Di Yao, Xintong Wang, Wei Yu et autres

Staphylococcus aureus is a leading cause of severe infections in humans and animals, and the emergence of multidrug-resistant strains highlights the need to develop effective vaccines to prevent such diseases. Epitope-based vaccines use short antigen-derived peptides corresponding to immune epitopes, which are …

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Attempt to use traveling pulsar wind nebula modeling on the enigmatic LHAASO dumbbell-like structure

Yihan Liu, Chengyu Shao, Yudong Cui

Context. The first Large High Altitude Air Shower Observatory (LHAASO) catalog presents six enigmatic ultra-high-energy (UHE) γ-ray sources with lonely > 25 TeV emission being detected, which are indicated as 1LHAASO: J0007+5659u, J0206+4302u, J0212+4254u, J0216+4237u, J1740+0948u, and J1959+1129u. No counterparts of the …

Roseicyclus amphidinii sp. nov., a novel bacterium isolated from the culture of a dinoflagellate Amphidinium carterae

Yudong Cui, Xiaoxin MO, Zhaobin Huang

A Gram-negative, rod-shaped and light pink-pigmented bacterial strain, designated Amp-Y-6T, was isolated from the culture of a dinoflagellate Amphidinium carterae CCMP1314. It can produce bacteriochlorophyll a. The 16S rRNA gene of strain Amp-Y-6T had the highest sequence similarity with Roseicyclus marinus CCMM001T …

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Detection of two TeV gamma-ray outbursts from NGC 1275 by LHAASO

Z. Cao, F Aharonian, Axikegu, Yucen Bai et autres

ABSTRACT The Water Cherenkov Detector Array (WCDA) is one of the components of Large High Altitude Air Shower Observatory (LHAASO) and can monitor any sources over two-thirds of the sky for up to 7 h per day with >98 per cent duty …

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A Unique Combination of Mn2+ and Aluminum Adjuvant Acted the Synergistic Effect

Yuwei Cen, Shujie Chen, Shuyu Wei, Shuangshuang Wu et autres

Introduction. The development of combinatorial adjuvants is a promising strategy to boost vaccination efficiency. Accumulating evidence indicates that manganese exerts strong immunocompetence and will become an enormous potential adjuvant. Here, we described a novel combination of Mn2+ plus aluminum hydroxide (AH) adjuvant …

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The cooperation between orf virus and Staphylococcus aureus leads to intractable lesions in skin infection

Yongzhong Yu, Yudong Cui, Baifen Song

A large amount of evidence shows that different kinds of microorganisms can jointly cope with environmental pressures including cell hosts. For example, in many cases, it has been found that secondary or mixed infection of animals caused by ORFV (an epitheliophilic Parapoxvirus) …

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PEI‐PLGA nanoparticles significantly enhanced the immunogenicity of IsdB137‐361 proteins from Staphylococcus aureus

Beiyan Wang, Yazun Dong, Yuwei Cen, Shujie Chen et autres

Abstract Introduction Staphylococcus aureus seriously threatens human and animal health. IsdB137‐361 of the iron surface determinant B protein (IsdB) from S. aureus exhibits the strong immunogenicity, but its immunoprotective effect is still to be further promoted. Because PEI‐PLGA nanoparticles are generated by …

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ORFV can carry TRAP gene expression via intracellular CRISPR/Cas9 gene editing technology

Yongzhong Yu, Fan Zhang, Xuyang Duan, ChaoQun Yang et autres

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Als3-Th-cell-epitope plus the combined adjuvant of MDP, CpG and FIA synergistically enhanced the immune responses triggered with recombinant TRAP proteins in mice

Jinzhu Ma, Wei Liu, Beiyang Wang, Simiao Yu et autres

Here, Als3-Th-cell-epitope （Als3 epitope） was connected to the N-terminal of TRAP by flexible linker, and the Als3-Th-cell-epitope-TRAP (ATT) proteins were prepared, then, the ATT proteins plus freund’s adjuvant were inoculated in mice to evaluate Als3 epitope to increase the immunogenicity of TRAP. …

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The O H system: A panorama view of the PPV-host interaction

Yongzhong Yu, Zhengxing Lian, Yudong Cui

Poxviruses are a family of specialized cytoplasm-parasitic DNA viruses that replicate and assembly in virus factory. In Parapoxvirus (PPV) genus, with the orf virus (ORFV) as a representative species of this genus, their behaviors are significantly different from that of Orthopoxvirus, and …

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Ethyl β-Carboline-3-Carboxylate Increases Cervical Cancer Cell Apoptosis Through ROS-p38 MAPK Signaling Pathway

Hu‐Nan Sun, DAN-PING XIE, Chenxi Ren, Xiao-Yu Guo et autres

BACKGROUND/AIM: Ethyl β-carboline-3-carboxylate (β-CCE) is one of the effective ingredients of Picrasma quassioides (P. quassioides). As a β-carboline alkaloid, it can antagonize the pharmacological effects of benzodiazepines by regulating neurotransmitter secretion through receptors, thus affecting anxiety and physiology. However, its efficacy in …

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