Valerie M. Weaver

The microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism

Kevin M. Tharp, Sangwoo Park, Greg A. Timblin, Alicia Richards et autres

Altered glucose metabolism is an auspicious feature of solid tumors, but is it an intrinsic property of tumor cells or a metabolic adaptation to the tumor microenvironment? Using normal epithelial cells cultured in a physiological culture medium under conditions that mimic the …

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Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells

Nadia M.E. Ayad, Johnathon N. Lakins, Ajinkya Ghagre, Allen J. Ehrlicher et autres

The role of morphogenetic forces in cell fate specification is an area of intense interest. Using an ectopically expressed nonphosphorylatable mutant of β-catenin (Y654F) in human embryonic stem cell colonies, we provide evidence that impeding tension-dependent Src-mediated β-catenin phosphorylation compromises BMP4-driven Brachyury …

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Data from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Won-Young Choi, Maria Farina-Morillas et autres

Abstract The CDKN2A locus, which is frequently deleted in pancreatic ductal adenocarcinoma (PDAC), encodes two tumor suppressors, ARF and INK4A, that may influence tumorigenesis through distinct mechanisms. Distinguishing their individual contributions to cancer could help improve the understanding of PDAC pathogenesis and …

Supplementary Figure S2 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Summary of types of mutations found in CDKN2AARF and CDKN2AINK4A in Group 1 to 4 PDACs.

Supplementary Figure S1 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Identification of 4 groups within TCGA PAAD data.

Supplementary Table S3 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

RNA-sequencing data

Supplementary Figure S3 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Analysis of PDAC development from adult mouse acinar cells across different Arf and Trp53 genotypes

Supplementary Figure S4 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

CDKN2A alterations are common in mouse KTC PDACs.

Supplementary Table S2 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Details of mouse acinar cell-derived tumors used for RNA-sequencing analysis

Supplementary Table S1 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Phenotypes in acinar cell of origin Arf knockout and double Arf and Trp53 knockout mouse cohorts

Supplementary Figure S6 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Expression of Ink4a and a p53 tumor suppression-associated gene (TSAG) signature

Supplementary Figure S5 from Inactivation of CDKN2AARF Promotes p53-Independent Remodeling of the PDAC Tumor Microenvironment

Sofia Ferreira, Brittany M. Flowers, Wonyoung Choi, Maria Farina-Morillas et autres

Transcriptome analysis of PDACs from KTC, KTC;Trp53fl/fl, KTC;Arffl/fl and KTC;Trp53fl/fl; Arffl/fl mice